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SUMO1 attenuates stress-induced ROS generation by inhibiting NADPH oxidase 2.

Abstract：

:Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation and its precise biological function is poorly understood. During our studies on heat-shock responses, we found that heat-shock stress increased SUMO1 conjugation in a dose-dependent manner. Intriguingly, SUMO1 conjugation resulted in decrease of intracellular ROS generation and protection cells from death under heat-shock stress. We showed that NADPH oxidase 2 (NOX2) is a target protein of sumoylation by SUMO1 using immunoprecipitation and is colocalized with SUMO1 at plasma membrane. Additionally, we demonstrated that the attenuation in intracellular ROS generation resulted from inhibition of NADPH oxidase complex (NOX) activity. These results suggested that SUMO1 plays an important role in modulation of NOX activity required for ROS generation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kim HJ,Yun J,Lee J,Hong H,Jeong J,Kim E,Bae YS,Lee KJ

doi

10.1016/j.bbrc.2011.06.025

subject

Has Abstract

pub_date

2011-07-08 00:00:00

pages

555-62

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(11)00983-1

journal_volume

410

pub_type

杂志文章

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