Leucine enkephalin antagonizes norepinephrine-induced 45Ca++ accumulation in rat atria.

Abstract:

:Exposure of rat atrial slices to 10(-5) M norepinephrine (NE) for 10 minutes increases 45Ca++ accumulation from 1.64 +/- 0.10 to 2.23 +/- 0.06 nmol/mg tissue. In the presence of leucine enkephalin (10(-8) M), NE-stimulated 45Ca++ uptake is reduced to 1.44 +/- 0.10 nmol/mg tissue. The effect of leu-enkephalin is reversed in the presence of 10(-7) M naloxone, NE-stimulated 45Ca++ uptake being increased to 2.17 +/- 0.15 nmol/mg tissue. The results support a direct interaction of leu enkephalin with beta-agonist-stimulated Ca++ flux in rat atria, and correlate with the previously reported enkephalin antagonism of NE-induced positive chronotropy in the same tissue.

authors

Ruth JA,Cuizon JV,Eiden LE

doi

10.1016/0006-291x(83)91233-0

subject

Has Abstract

pub_date

1983-12-16 00:00:00

pages

536-40

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(83)91233-0

journal_volume

117

pub_type

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