Activation of calcium-sensing receptor-mediated autophagy in angiotensinII-induced cardiac fibrosis in vitro.

abstract：:A 5T/6T polymorphism in the human MMP-3 promoter affects gene expression and impacts the risk and/or severity of various pathological conditions. Chromatin immunoprecipitation (ChIP) in human fibroblasts homozygous for the 6T site demonstrate that it is bound by NF-kappaB and ZBP-89 transcription factors in its native...

journal_title：Biochemical and biophysical research communications

authors： Borghaei RC,Gorski G,Javadi M,Mariah Chambers.

更新日期：2009-05-01 00:00:00

abstract：:The forced expression of the catalytic subunit of human telomerase, hTERT, produces telomerase activity, allows telomere maintenance, and extends the cellular life span of IMR90 human lung fibroblasts. The mutation D869A abolishes both the catalytic activity of hTERT and its ability to extend cellular life span, demon...

journal_title：Biochemical and biophysical research communications

authors： Ouellette MM,Aisner DL,Savre-Train I,Wright WE,Shay JW

更新日期：1999-01-27 00:00:00

abstract：:The acute phase of an inflammation induced in young rats, at various ages between 1 and 21 days after birth, by a single subcutaneous turpentine injection, is accompanied by a 35%-45% decrease of the alpha 1-foetoprotein serum concentrations. This fall is demonstrated with equilibrium dialysis binding methods, evidenc...

journal_title：Biochemical and biophysical research communications

authors： Savu L,Zouaghi H,Nunez EA

更新日期：1983-02-10 00:00:00

abstract：:In the investigation of the intracellular sites of insulin degradation, it might be important whether receptor-bound insulin could be a substrate for insulin-degrading enzyme (IDE). Insulin receptor and IDE were purified from rat liver using a wheat germ agglutinin column and monoclonal anti-IDE antibody affinity colu...

journal_title：Biochemical and biophysical research communications

authors： Yonezawa K,Yokono K,Shii K,Hari J,Yaso S,Amano K,Sakamoto T,Kawase Y,Akiyama H,Nagata M

更新日期：1988-01-29 00:00:00

abstract：:One point mutation which converts glycine-317 to aspartate of tissue-nonspecific alkaline phosphatase (TNSALP) was reported to be associated with lethal hypophosphatasia (Greenberg, C. R., et al. Genomics 17, 215-217, 1993). In order to define the molecular defect of TNSALP underlying the pathogenesis of hypophosphata...

journal_title：Biochemical and biophysical research communications

authors： Fukushi M,Amizuka N,Hoshi K,Ozawa H,Kumagai H,Omura S,Misumi Y,Ikehara Y,Oda K

更新日期：1998-05-29 00:00:00

abstract：:The endoplasmic reticulum (ER) is an organelle in which most membrane and secretory proteins are synthesized. If these proteins are not folded correctly, unfolded proteins accumulate in the ER lumen, causing a cellular situation known as ER stress. Recently, many studies on the relationship between ER stress and disea...

journal_title：Biochemical and biophysical research communications

authors： Hosoda A,Maruyama A,Oikawa D,Oshima Y,Komachi Y,Kanai G,Sato H,Iwawaki T

更新日期：2011-02-04 00:00:00

abstract：:Neural crest cells originating from the posterior rhombencephalon migrate to the cardiac outflow tract and participate in division of the aorta and pulmonary trunk. Ablation of this region of premigratory neural crest in the chick embryos results in nondivision of the outflow vessels. Subtractive hybridization was use...

journal_title：Biochemical and biophysical research communications

authors： Kirby ML,Cheng G,Stadt H,Hunter G

更新日期：1995-07-17 00:00:00

abstract：:Recent progress in the field of mesenchymal stem cell (MSC) biology has enabled their clinical application. In the autologous cell transplantation therapy, the source of MSCs are quite important to reduce patients' physical burden. In this study, we isolated MSCs from the synovial fluid (SF) and synovial membrane (Syn...

journal_title：Biochemical and biophysical research communications

authors： Amemiya M,Tsuji K,Katagiri H,Miyatake K,Nakagawa Y,Sekiya I,Muneta T,Koga H

更新日期：2020-03-05 00:00:00

abstract：:Alpha-bulnesene is a sesquiterpenoid isolated from the water extract of Pogostemon cablin. It showed a potent and concentration-dependent inhibitory effect on platelet-activating factor (PAF) and arachidonic acid (AA) induced rabbit platelet aggregation. In a radioligand binding assay for the PAF receptor, alpha-bulne...

journal_title：Biochemical and biophysical research communications

authors： Hsu HC,Yang WC,Tsai WJ,Chen CC,Huang HY,Tsai YC

更新日期：2006-07-07 00:00:00

abstract：:One of the mechanisms underlying the induction of human inducible nitric oxide synthase (hiNOS) by cytokines is transcriptional regulation. However, previous reports suggest that in human cells, the cytokine activation of the hiNOS expression is accompanied by a drastic increase in cellular mRNA and protein content, b...

journal_title：Biochemical and biophysical research communications

authors： Nunokawa Y,Oikawa S,Tanaka S

更新日期：1997-04-17 00:00:00

abstract：:Endochondral bone formation is an important process in development and growth of the skeleton; still many of the mechanisms of growth cartilage remain unknown. The aim of this study was to identify genes specifically expressed in growth cartilage by constructing a subtraction cDNA library of the articular-epiphyseal c...

journal_title：Biochemical and biophysical research communications

authors： Johannessen MK,Skretting G,Ytrehus B,Røed KH

更新日期：2007-03-23 00:00:00

abstract：:The cytoplasmic domain of the neural cell adhesion molecule (NCAM) contains multiple phosphorylation sites. We report here that in addition to serine and threonine residues a tyrosine of the NCAM180 isoform is phosphorylated as shown by phosphoamino acid analysis. Exchange of the only cytoplasmic tyrosine at position ...

journal_title：Biochemical and biophysical research communications

authors： Diestel S,Laurini C,Traub O,Schmitz B

更新日期：2004-09-10 00:00:00

abstract：:Baicalin (BA) has been shown with anti-HIV-1 activity. Zinc is a nutrient element. The anti-HIV-1 activity of zinc complex of baicalin (BA-Zn) in vitro was studied and compared with the anti-HIV-1 activities between BA and BA-Zn in the present study. Our results suggested that BA-Zn has lower cytotoxicity and higher a...

journal_title：Biochemical and biophysical research communications

authors： Wang Q,Wang YT,Pu SP,Zheng YT

更新日期：2004-11-12 00:00:00

abstract：:We previously demonstrated several nicotinic acetylcholine receptor (nAChR) subunits and associated proteins in human sperm. Here, we identified in sperm for the first time two additional nAChR-associated molecules: (1) agrin(SN)Z(+) in human sperm localized in the posterior post-acrosomal, neck, and flagellar mid-pie...

journal_title：Biochemical and biophysical research communications

authors： Kumar P,Ferns MJ,Meizel S

更新日期：2006-04-07 00:00:00

abstract：:Guanine nucleotides and monovalent cations decrease the affinity of cardiac muscarinic receptors for agonists and are required for muscarinic receptor mediated inhibition of adenylate cyclase. N-ethylmaleimide abolished the effects of Gpp(NH)p on the ability of the agonist oxotremorine to inhibit the binding of the an...

journal_title：Biochemical and biophysical research communications

authors： McMahon KK,Hosey MM

更新日期：1983-02-28 00:00:00

abstract：:Cardiac ventricular myocytes exhibit a protein kinase A-dependent Cl(-) current (ICl.PKA) mediated by the cystic fibrosis transmembrane conductance regulator (CFTR). There is conflicting evidence regarding the ability of the divalent cation nickel (Ni(2+)), which has been used widely in vitro in the study of other car...

journal_title：Biochemical and biophysical research communications

authors： Barman PP,Cheng H,Hancox JC,James AF

更新日期：2013-03-01 00:00:00

abstract：:The family of staphylococcal superantigen-like proteins (SSLs) have a structure similar to bacterial superantigens but exhibit no superantigenic activity. These exoproteins have recently been shown to disturb the host immune defense system. One family member, SSL5, was reported to bind to human leukocyte P-selectin gl...

journal_title：Biochemical and biophysical research communications

authors： Oku T,Kurisaka C,Ando Y,Tsuji T

更新日期：2019-01-22 00:00:00

abstract：:Two common non-steroidal anti-inflammatory drugs (NSAIDs) and their nitric oxide (NO) adducts were evaluated for effects on stomach and thymus. Following 4-h duration (acute) oral dosing of fasted male Wistar rats, 1.33 x 10(-4)mol/kg of ibuprofen caused significant visual irritation score and microscopic thinning, al...

journal_title：Biochemical and biophysical research communications

authors： Downing JE,Madden JC,Ingram MJ,Rostron C

更新日期：2005-08-26 00:00:00

abstract：:Intracellular B(12) metabolism involves a B(12) trafficking chaperone CblC that is well conserved in mammals including human. The protein CblC is known to bind cyanocobalamin (CNCbl, vitamin B(12)) inducing the base-off transition and convert it into an intermediate that can be used in enzyme cofactor synthesis. The b...

journal_title：Biochemical and biophysical research communications

authors： Jeong J,Kim J

更新日期：2011-08-26 00:00:00

abstract：:Dietary supplementation with coenzyme Q (CoQ) has been proposed to have anti-atherogenic effects by virtue of its antioxidant capacity. To investigate this question, the leukocyte status of 5 males and 5 females (52-68 years) was evaluated before and after supplementation with 200mg CoQ/day for 5 and 10 weeks. CoQ was...

journal_title：Biochemical and biophysical research communications

authors： Turunen M,Wehlin L,Sjöberg M,Lundahl J,Dallner G,Brismar K,Sindelar PJ

更新日期：2002-08-16 00:00:00

abstract：:A key feature of O2 sensing by chemoreceptor tissues is the hypoxic inhibition of K+ channels. However, mechanisms coupling a fall of pO2 to channel closure differ between tissues: O2 regulation of K+ channels in chemoreceptive neuroepithelial bodies and their immortal counterparts, H146 cells, involves altered reacti...

journal_title：Biochemical and biophysical research communications

authors： O'Kelly I,Peers C,Kemp PJ

更新日期：2001-05-25 00:00:00

abstract：:Picrotoxin is a CYP2B inducer in mammals (1). However, in primary cultures of rainbow trout hepatocytes we showed CYP1A1 gene expression to be strongly induced as characterized by 7-ethoxyresorufin-O-deethylase activity, immunoblots of CYP1A1 protein, and Northern blots of CYP1A1 mRNA. Induction of CYP1A1 in these cel...

journal_title：Biochemical and biophysical research communications

authors： Sadar MD,Ash R,Andersson TB

更新日期：1995-09-25 00:00:00

abstract：:Elevated expression of fucosylated glycoconjugates and fucosyltransferases (Fuc-Ts) is found in various tumor cells and has been correlated with aspects of tumor progression such as cell adhesion and metastasis. Thus, fucosyltransferase inhibitors are potentially useful as anti-tumor agents. In the present study, thre...

journal_title：Biochemical and biophysical research communications

authors： Lin TW,Chang WW,Chen CC,Tsai YC

更新日期：2005-06-17 00:00:00

abstract：:6-amino-4-(4-phenoxyphenylethylamino)quinazoline (QNZ) is an excellent quinazoline-containing NF-κB inhibitor also acting as a novel anticancer agent. Considering both the medicinal significance of quinazoline scaffold and the tunable functionality of Michael acceptor-centric pharmacophores in the electrophilicity-bas...

journal_title：Biochemical and biophysical research communications

authors： Shi H,Li Y,Ren X,Zhang Y,Yang Z,Qi C

更新日期：2017-04-29 00:00:00

abstract：:Inducible nitric oxide (iNOS) is closely correlated with chronic inflammation in hepatitis B virus X protein (HBx)-induced hepatocellular carcinoma (HCC). However, the molecular mechanisms through which iNOS contribute to hepatocarcinogenesis remain poorly understood. Therefore, we investigated the role of iNOS in sig...

journal_title：Biochemical and biophysical research communications

authors： Park YH,Shin HJ,Kim SU,Kim JM,Kim JH,Bang DH,Chang KT,Kim BY,Yu DY

更新日期：2013-05-31 00:00:00

abstract：:Partially purified trehalose phosphorylase (EC 2.4.1.64) from Euglena gracilis SM-ZK was inhibited by fructose 2,6-bisphosphate in both synthetic and degradative directions. Ki value for trehalose phosphorolysis was 1.2 microM and that for trehalose synthesis was 0.5 microM. Functions of fructose 2,6-bisphosphate in E...

journal_title：Biochemical and biophysical research communications

authors： Miyatake K,Kuramoto Y,Kitaoka S

更新日期：1984-08-16 00:00:00

abstract：:Glucose transporter-1 (GLUT1) is important in placental glucose transport. However, the mechanism of regulation of placental GLUT1 expression remains to be elucidated. We show here that the level of GLUT1 protein in rat choriocarcinoma cells (Rcho-1) decreased during differentiation. To analyze the regulatory mechanis...

journal_title：Biochemical and biophysical research communications

authors： Okamoto Y,Sakata M,Yamamoto T,Nishio Y,Adachi K,Ogura K,Yamaguchi M,Takeda T,Tasaka K,Murata Y

更新日期：2001-11-09 00:00:00

abstract：:We propose a multiple alignment of the sequence of formate dehydrogenase with the D-specific 2-hydroxy acid dehydrogenases family. Structurally conserved regions are predicted for those sequences corresponding to important regions of the catalytic and the coenzyme binding domains defined from the known three-dimension...

journal_title：Biochemical and biophysical research communications

authors： Vinals C,Depiereux E,Feytmans E

更新日期：1993-04-15 00:00:00

abstract：:Studies on the physiological role of motilin, and more recently, on the relationship between motilin and erythromycin A, have been hampered by the lack of antagonists. We now have discovered such a compound. ANQ-11125 displaces motilin bound to an homogenate of rabbit antral smooth muscle tissue. The dissociation cons...

journal_title：Biochemical and biophysical research communications

authors： Peeters TL,Depoortere I,Macielag MJ,Dharanipragada R,Marvin MS,Florance JR,Galdes A

更新日期：1994-01-28 00:00:00

abstract：:Young lean (Fa/?) and obese (fa/fa) rats were treated with the thermogenic beta-adrenoceptor agonist, BRL 26830, for 3 weeks. In lean rats this treatment had no effect on body weight but there was a marked increase in the insulin sensitivity of soleus muscle strips with respect to glycolytic rate. Treatment of obese r...

journal_title：Biochemical and biophysical research communications

authors： Challiss RA,Budohoski L,Newsholme EA,Sennitt MV,Cawthorne MA

更新日期：1985-04-30 00:00:00