Abstract:
:We propose a multiple alignment of the sequence of formate dehydrogenase with the D-specific 2-hydroxy acid dehydrogenases family. Structurally conserved regions are predicted for those sequences corresponding to important regions of the catalytic and the coenzyme binding domains defined from the known three-dimensional structure of the formate dehydrogenase, namely the nicotinamide binding site (beta D to beta F) and the beta A-loop-alpha B region containing the typical glycine pattern of the adenosine binding site, the catalytic histidine/aspartic acid pair and an arginine probably involved in the interaction with the carboxyl group of the substrate.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Vinals C,Depiereux E,Feytmans Edoi
10.1006/bbrc.1993.1398subject
Has Abstractpub_date
1993-04-15 00:00:00pages
182-8issue
1eissn
0006-291Xissn
1090-2104pii
S0006-291X(83)71398-7journal_volume
192pub_type
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