Prediction of structurally conserved regions of D-specific hydroxy acid dehydrogenases by multiple alignment with formate dehydrogenase.

Abstract:

:We propose a multiple alignment of the sequence of formate dehydrogenase with the D-specific 2-hydroxy acid dehydrogenases family. Structurally conserved regions are predicted for those sequences corresponding to important regions of the catalytic and the coenzyme binding domains defined from the known three-dimensional structure of the formate dehydrogenase, namely the nicotinamide binding site (beta D to beta F) and the beta A-loop-alpha B region containing the typical glycine pattern of the adenosine binding site, the catalytic histidine/aspartic acid pair and an arginine probably involved in the interaction with the carboxyl group of the substrate.

authors

Vinals C,Depiereux E,Feytmans E

doi

10.1006/bbrc.1993.1398

subject

Has Abstract

pub_date

1993-04-15 00:00:00

pages

182-8

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)71398-7

journal_volume

192

pub_type

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