Abstract:
:In the brain angiotensin converting enzyme is highly localized to a striatonigral pathway, which contains no endogenous angiotensin. Substance P, also localized to a striatonigral pathway, is degraded by ACE via two different pathways. The lung and striatal isozymes of angiotensin converting enzyme exhibit differential cleavage of substance P, with lung preferring an initial tripeptide cleavage, and striatum an initial dipeptide cleavage. Substance K is degraded by the striatal isozyme but is not cleaved by the lung isozyme. Substance P 5-11 is not cleaved by either form of angiotensin converting enzyme.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Thiele EA,Strittmatter SM,Snyder SHdoi
10.1016/0006-291x(85)91681-xsubject
Has Abstractpub_date
1985-04-16 00:00:00pages
317-24issue
1eissn
0006-291Xissn
1090-2104pii
0006-291X(85)91681-Xjournal_volume
128pub_type
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