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Conformational states of Leu5- and Met5-enkephalins in solution.

Abstract：

:The molecular conformations of Leu5- and Met5-enkephalins in aqueous and DMSO solutions were investigated by FT-IR and laser Raman spectroscopic methods. The amide I, II, and III regions in the FT-IR spectra of Leu5- and Met5-enkephalins in aqueous solution were analyzed by performing Fourier self-deconvolution of the bands. Leu5-enkephalin in aqueous solution is found to exist in both type II beta-turn and beta-sheet structures, whereas Met5-enkephalin has a lesser tendency to form beta-turn structure in aqueous solution. It is likely that these different conformers of enkephalins might bind to different receptor types.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Renugopalakrishnan V,Rapaka RS,Collette TW,Carreira LA,Bhatnagar RS

doi

10.1016/0006-291x(85)90288-8

subject

Has Abstract

pub_date

1985-02-15 00:00:00

pages

1029-35

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(85)90288-8

journal_volume

126

pub_type

杂志文章

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