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Vascular smooth muscle cells as target for estrogen.

Abstract：

:ER mRNA was detected as 6.0 kb band by Northern blot analysis in vascular smooth muscle cells (VSMC) derived from rat aorta. The presence of ER mRNA in VSMC was confirmed by reverse transcriptase-polymerase chain reaction using specific primers for rat ER cDNA. In addition, the immunocytochemistry of ER was performed in VSMC using a monoclonal anti-ER antibody which recognizes DNA-binding domain of ER. The immunoreactivity was distributed in the cytoplasm as well as in the nuclei. Thus, the expression of ER in VSMC was demonstrated at both the protein and the mRNA level. Furthermore, the expression of c-fos mRNA in VSMC was found up-regulated by 17 beta-estradiol treatment within 30 min. The observation that VSMC possess ER and respond to estrogen supports the idea that estrogen may directly influence vascular cell system through the ER.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Orimo A,Inoue S,Ikegami A,Hosoi T,Akishita M,Ouchi Y,Muramatsu M,Orimo H

doi

10.1006/bbrc.1993.2106

subject

Has Abstract

pub_date

1993-09-15 00:00:00

pages

730-6

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)72106-6

journal_volume

195

pub_type

杂志文章

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