Differential expression of mammalian TRP homologues across tissues and cell lines.

Abstract:

:Mammalian homologues of the Drosophila trp gene have been invoked as the structural basis for the currents associated with capacitative Ca2+ entry (CCE) in many cell types. Trp homologues are members of a large protein family that may associate as channel subunits providing an explanation for the functional diversity of store-operated channels observed in these cells. However, there is little information as to which of these genes are co-expressed at the cellular level. We have examined the tissue specific expression of five mammalian trp genes and determined which are co-expressed in five different cell lines. The results show tissue- and cell-specific co-expression of multiple trp forms. This implies that the subunit composition of a particular CCE channel may vary depending on the cell type.

authors

Garcia RL,Schilling WP

doi

10.1006/bbrc.1997.7458

subject

Has Abstract

pub_date

1997-10-09 00:00:00

pages

279-83

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(97)97458-1

journal_volume

239

pub_type

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