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Ionophore-induced Cl- transport in human erythrocyte suspensions: a multinuclear magnetic resonance study.

Abstract：

:To investigate the effect of ionophores on Cl- distribution in human erythrocyte suspensions, we measured the membrane potential by using 19F and 31P NMR methods. Incubation of human erythrocytes with 0.005 mM of the neutral ionophores valinomycin and nonactin resulted in membrane potentials of -21.2 and -17.8 mV in the presence and absence of DIDS. However, 0.020 mM of the carboxylic ionophores lasalocid, monensin, and nigericin yielded membrane potentials similar to those measured in the absence of ionophore (-9.4 mV). In methanol, the 35Cl- NMR linewidth in the presence of valinomycin was twice as broad as those observed in the presence of carboxylic ionophores, suggesting that neutral ionophores induce Cl- efflux in part via ion pairing.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wittenkeller L,Mota de Freitas D,Ramasamy R

doi

10.1016/0006-291x(92)90678-e

subject

Has Abstract

pub_date

1992-04-30 00:00:00

pages

915-21

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(92)90678-E

journal_volume

184

pub_type

杂志文章

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