Measurement of intracellular IP3 during Ca2+ oscillations in mouse eggs with GFP-based FRET probe.

abstract：:15-Deoxy-prostaglandin J(2)(15d-PGJ(2)) is an endogenous ligand of peroxisome proliferator-activated receptor gamma (PPARgamma) and plays an important role in the regulation of endothelial cell growth and apoptosis. However, the detailed mechanisms are poorly understood. We hypothesized that 15d-PGJ(2) might affect PD...

journal_title：Biochemical and biophysical research communications

authors： Zhang J,Fu M,Zhao L,Chen YE

更新日期：2002-10-18 00:00:00

abstract：:A novel ribosome-inactivating protein designated beta-kirilowin was isolated from the seeds of Trichosanthes kirilowii. The proteins exhibited strong abortifacient activity in pregnant mice and produced a single band after SDS-polyacrylamide gel electrophoresis with an apparent mol. wt. of 27,500 daltons. It was activ...

journal_title：Biochemical and biophysical research communications

authors： Dong TX,Ng TB,Yeung HW,Wong RN

更新日期：1994-02-28 00:00:00

abstract：:E3b1, a binding partner of Eps8, plays a critical role in receptor tyrosine kinase (RTK)-mediated Rac activation by facilitating the interaction of Eps8 with Sos-1 and the consequent activation of the Rac-specific guanine nucleotide exchange factor activity of Sos-1. Here we present evidence that E3b1 levels are regul...

journal_title：Biochemical and biophysical research communications

authors： Chi S,Chang S,Park D

更新日期：2004-06-25 00:00:00

abstract：:The production of 1 alpha,25-dihydroxyvitamin D3 is known to be down regulated by 1 alpha,25-dihydroxyvitamin D3 itself. It was recently shown that liver mitochondrial sterol 27-hydroxylase CYP27, present also in kidney, catalyzes 1 alpha-hydroxylation of 25-hydroxyvitamin D3. Treatment of vitamin D-deficient rats wit...

journal_title：Biochemical and biophysical research communications

authors： Axén E,Postlind H,Wikvall K

更新日期：1995-10-04 00:00:00

abstract：:NO-donating aspirin (NO-ASA) is a promising anticancer drug. We studied the contribution of NO-ASA's components (ASA, NO-releasing moiety, and spacer linking them) to its effect. The ASA and NO-releasing moieties play no biological role: ASA inhibits the growth of colon cancer cells >100-fold less potently that NO-ASA...

journal_title：Biochemical and biophysical research communications

authors： Kashfi K,Rigas B

更新日期：2007-07-13 00:00:00

abstract：:The mechanism and target genes of regulation by Forkhead (FHA) domain-containing transcription factors have not yet been documented in Archaea. In this study, using a bacterial one-hybrid technique, we successfully screened and identified for the first time a target gene regulated by ST0829, an FHA domain-containing p...

journal_title：Biochemical and biophysical research communications

authors： Duan X,He ZG

更新日期：2011-04-01 00:00:00

abstract：:A novel cDNA clone was identified through yeast two-hybrid experiments. Following cross-examination between the cDNA clones, EST clones, and the cosmid clone, we could digitally assemble a new zinc finger transcription factor gene. This predicted gene has a cDNA size of about 1960 bp and is translated into a 487-amino...

journal_title：Biochemical and biophysical research communications

authors： Lin W,Lai CH,Tang CJ,Huang CJ,Tang TK

更新日期：1999-11-02 00:00:00

abstract：:Sifuvirtide is a gp41 based peptide that inhibits HIV-1 fusion with the host cells and is currently under clinical trials. Previous studies showed that sifuvirtide partitions preferably to saturated phosphatidylcholine lipid membranes, instead of fluid-phase lipid vesicles. We extended the study to the interaction of ...

journal_title：Biochemical and biophysical research communications

authors： Matos PM,Freitas T,Castanho MA,Santos NC

更新日期：2010-12-17 00:00:00

abstract：:To investigate the involvement of thyroid hormone on the release of atrial natriuretic polypeptide (ANP), we have measured immunoreactive ANP in the atria and plasma of experimental hyperthyroid and hypothyroid rats. Plasma ANP was higher (p less than 0.05) in hyperthyroid rats and was lower (p less than 0.05) in hypo...

journal_title：Biochemical and biophysical research communications

authors： Kohno M,Takaori K,Matsuura T,Murakawa K,Kanayama Y,Takeda T

更新日期：1986-01-14 00:00:00

abstract：:The correlation between genomic G+C content and optimal growth temperature in prokaryotes has gained renewed interest after Musto et al. [H. Musto, H. Naya, A. Zavala, H. Romero, F. Alvarex-Valin, G. Bernardi, Correlations between genomic GC levels and optimal growth temperatures in prokaryotes, FEBS Lett. 573 (2004) ...

journal_title：Biochemical and biophysical research communications

authors： Wang HC,Susko E,Roger AJ

更新日期：2006-04-14 00:00:00

abstract：:Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Kirsten rat sarcoma viral oncogene homolog (KRAS) is frequently mutated in CRC, and KRAS mutations promote cell motility, growth, and survival. We previously revealed that the expression of phospholipase C (PLC) δ1, one of the most...

journal_title：Biochemical and biophysical research communications

authors： Shimozawa M,Anzai S,Satow R,Fukami K

更新日期：2017-07-08 00:00:00

abstract：:Recent efforts have underlined the role of Serine/Threonine Protein Kinases (STPKs) in growth, pathogenesis and cell wall metabolism in mycobacteria. Herein, we demonstrated that the Mycobacterium tuberculosis EthR, a transcriptional repressor that regulates the activation process of the antitubercular drug ethionamid...

journal_title：Biochemical and biophysical research communications

authors： Leiba J,Carrère-Kremer S,Blondiaux N,Dimala MM,Wohlkönig A,Baulard A,Kremer L,Molle V

更新日期：2014-04-18 00:00:00

abstract：:We have previously shown that estrogen effects in the heart include direct hormone effects on the myocardium. In a recent study we found that one beneficial effect of estradiol on the myocardium is the inhibition of apoptosis in cardiac myocytes. This effect was associated with a reduction of NF-kappaB activity. In th...

journal_title：Biochemical and biophysical research communications

authors： Pelzer T,Neumann M,de Jager T,Jazbutyte V,Neyses L

更新日期：2001-09-07 00:00:00

abstract：:Huntington's disease (HD) is caused by mutations that expand a polyglutamine region in the amino-terminal domain of Huntingtin (Htt), leading to the accumulation of intracellular inclusions and progressive neurodegeneration. Recent reports indicate the engagement of endoplasmic reticulum (ER) stress responses in human...

journal_title：Biochemical and biophysical research communications

authors： Zuleta A,Vidal RL,Armentano D,Parsons G,Hetz C

更新日期：2012-04-13 00:00:00

abstract：:Arsenic trioxide (ATO) is remarkably effective for treating acute promyelocytic leukemia. Here, we find that ATO treatment of NB4 and K562 leukemic cells induces activation of ASK1. ASK1 activation was induced most significantly at low concentrations of ATO, where G2/M arrest but not apoptosis was induced. On the othe...

journal_title：Biochemical and biophysical research communications

authors： Yan W,Arai A,Aoki M,Ichijo H,Miura O

更新日期：2007-04-20 00:00:00

abstract：:We have identified and characterized insulin receptors on Chinese hamster ovary (CHO) cells. Insulin binds in a time, temperature and pH dependent fashion and insulin analogues compete for 125I-insulin binding in order of their biological potencies. Furthermore, two CHO cell glycosylation mutants, B4-2-1, lacking high...

journal_title：Biochemical and biophysical research communications

authors： Podskalny J,McElduff A,Gorden P

更新日期：1984-11-30 00:00:00

abstract：:We have used electron paramagnetic resonance (EPR) to examine the structural impact of oxidizing specific methionine (M) side chains in calmodulin (CaM). It has been shown that oxidation of either M109 or M124 in CaM diminishes CaM regulation of the muscle calcium release channel, the ryanodine receptor (RyR), and tha...

journal_title：Biochemical and biophysical research communications

authors： McCarthy MR,Thompson AR,Nitu F,Moen RJ,Olenek MJ,Klein JC,Thomas DD

更新日期：2015-01-09 00:00:00

abstract：:The fibroblast growth factors (FGFs) play important roles in morphogenesis, angiogenesis, tissue remodeling, and carcinogenesis. Human FGF-20 has been cloned and characterized in this study. FGF-20 encodes a 211-amino-acid polypeptide with the FGF-core domain. A strong hydrophobic region was found in the FGF-core doma...

journal_title：Biochemical and biophysical research communications

authors： Kirikoshi H,Sagara N,Saitoh T,Tanaka K,Sekihara H,Shiokawa K,Katoh M

更新日期：2000-08-02 00:00:00

abstract：:We have partially characterized the properties of a specific acetylhydrolase in plasma from spontaneous hypertensive rats. This enzyme inactivates 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a lipid involved in platelet aggregating, hypotensive, and allergic responses) by removal of the acetate group. The extent of ...

journal_title：Biochemical and biophysical research communications

authors： Blank ML,Hall MN,Cress EA,Snyder F

更新日期：1983-06-15 00:00:00

abstract：:RhoD is a member of the classical Rho GTPases and it has an essential role in the regulation of actin dynamics. Furthermore, RhoD also localizes to early endosomes and recycling endosomes, indicating additional roles in the regulation of endosome trafficking. A yeast two-hybrid screen identified Zipper-Interacting Pro...

journal_title：Biochemical and biophysical research communications

authors： Nehru V,Almeida FN,Aspenström P

更新日期：2013-04-05 00:00:00

abstract：:Kinetics measurements of the electron transfer between ferricytochrome c and liposomal ferrocytochrome c1 (with and without the hinge protein) were performed. The observed rate constants(kobs) of electron transfer between liposomal ferrocytochrome c1 and ferricytochrome c at different ionic strengths were measured in ...

journal_title：Biochemical and biophysical research communications

authors： Kim CH,King TE,Balny C

更新日期：1989-08-30 00:00:00

abstract：:Cancer cell molecular mimicry of stem cells (SC) follows with enhanced proliferative and renewal capacities. In support, numerous mediators of SC self-renewal have been evinced to exhibit oncogenic potential. More and more researches showed that the embryonic stem cell self-renewal genes express in various cancer cell...

journal_title：Biochemical and biophysical research communications

authors： Deng L,Xiang X,Yang F,Xiao D,Liu K,Chen Z,Zhang R,Feng G

更新日期：2017-08-19 00:00:00

abstract：:Here we investigate the effects of the dihydropyridine-type antagonists of calcium channels nitrendipine, nimodipine, nisoldipine and the calcium channel agonist BAY K 8644 on the induction of nitric oxide synthase (NOS) by bacterial endotoxin (lipopolysaccharide; LPS) in J774.2 macrophages cultured in vitro. Pretreat...

journal_title：Biochemical and biophysical research communications

authors： Szabó C,Thiemermann C,Vane JR

更新日期：1993-10-29 00:00:00

abstract：:Gemin4 is a ubiquitously expressed multifunctional protein that is involved in U snRNP assembly, apoptosis, nuclear/cytoplasmic transportation, transcription, and RNAi pathways. Gemin4 is one of the core components of the Gemin-complex, which also contains survival motor neuron (SMN), the seven Gemin proteins (Gemin2-...

journal_title：Biochemical and biophysical research communications

authors： Lorson MA,Dickson AM,Shaw DJ,Todd AG,Young EC,Morse R,Wolstencroft C,Lorson CL,Young PJ

更新日期：2008-10-10 00:00:00

abstract：:Recent advances in mass spectrometry have expanded our knowledge of lipids and lipid metabolic pathways involved in many (patho)physiological events. Targeted and non-targeted lipidomics are powerful analytical strategies with distinct features, and a combination of these two approaches is often employed to maximize t...

journal_title：Biochemical and biophysical research communications

authors： Lee HC,Yokomizo T

更新日期：2018-10-07 00:00:00

abstract：:The effects of high (28mM) D-glucose (HG) on the cell cycle progression were investigated in rat aorta vascular smooth muscle cells (VSMCs) in primary culture, using an immunocytochemical analysis of cell-cycle-specific nuclear antigens. HG had no effect on the cell cycle of the serum-deprived G0 cells, whereas platel...

journal_title：Biochemical and biophysical research communications

authors： Hiroishi G,Kobayashi S,Nishimura J,Inomata H,Kanaide H

更新日期：1995-06-15 00:00:00

abstract：:Parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor expressed in rat cultured cortical type I astrocytes was identified and characterized. Northern blot analysis demonstrated that the PTH/PTHrP receptor mRNA is expressed in astrocytes. A human PTH fragment, PTH [1-34], stimulated adenylate c...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto H,Aino H,Ogawa N,Nagata S,Baba A

更新日期：1994-04-29 00:00:00

abstract：:Complementary DNA corresponding to total poly(A)+-RNA from the human A431 epidermoid carcinoma cell line was cloned in the phage expression vector lambda gt 11. An epidermal growth factor (EGF) receptor cDNA clone was obtained by screening of the expression library with a rabbit polyclonal antibody (IgG), raised to th...

journal_title：Biochemical and biophysical research communications

authors： Simmen FA,Gope ML,Schulz TZ,Wright DA,Carpenter G,O'Malley BW

更新日期：1984-10-15 00:00:00

abstract：:Trilobolide and 2,5-di(tert-butyl)-1,4-benzohydroquinone (BHQ) are potent inhibitors of the Ca(2+)-ATPase of skeletal muscle sarcoplasmic reticulum. Desoxytrilobolide and 2,5-di(tert-butyl)-1,4-diacetylphenol (acetyl-BHQ) have much lower potencies than their parent compounds and 2,5-di(tert-butyl)-1,4-benzoquinone (BQ...

journal_title：Biochemical and biophysical research communications

authors： Wictome M,Holub M,East JM,Lee AG

更新日期：1994-03-15 00:00:00

abstract：:Precise control of neuronal migration is essential for the development of the neocortex. However, the molecular mechanisms underlying neuronal migration remain largely unknown. Here we identified helix-loop-helix transcription factor Ebf3 as a Prdm8 target gene, and found that Ebf3 is a key regulator of neuronal migra...

journal_title：Biochemical and biophysical research communications

authors： Iwai R,Tabata H,Inoue M,Nomura KI,Okamoto T,Ichihashi M,Nagata KI,Mizutani KI

更新日期：2018-01-01 00:00:00