Electron transfer between liposomal cytochrome c1 and cytochrome c: catalytic implications of electrostatic potentials.

abstract：:Leucine-rich alpha(2)-glycoprotein (LRG) is a plasma protein in which leucine-rich repeats (LRRs) were first discovered. Although the physiological function of LRG is not known, increases in the serum level of LRG have been reported in various diseases. In this study, we found that LRG was induced by recombinant human...

journal_title：Biochemical and biophysical research communications

authors： Shirai R,Hirano F,Ohkura N,Ikeda K,Inoue S

更新日期：2009-05-15 00:00:00

abstract：:The gonadotropin secretory response of anterior pituitary cells to phorbol esters includes both extracellular Ca2(+)-dependent and -independent components (Stojilković et al, 1988; J. Biol. Chem. 263, 17301-17306, 1988). In cultured pituitary cells, measurements of [Ca2+]i using Fura-2 and of LH release during cell pe...

journal_title：Biochemical and biophysical research communications

authors： Izumi S,Stojilković SS,Iida T,Krsmanović LZ,Omeljaniuk RJ,Catt KJ

更新日期：1990-07-16 00:00:00

abstract：:HspA1A, a seventy-kilodalton heat shock protein, binds to specific anionic lipids and this interaction regulates important physiological phenomena like apoptosis, tumor growth, and lysosomal rescue. However, whether HspA1A binds to phosphoinositides has yet to be established and quantified. Therefore, in this study, w...

journal_title：Biochemical and biophysical research communications

authors： McCallister C,Kdeiss B,Oliverio R,Nikolaidis N

更新日期：2016-03-25 00:00:00

abstract：:Cytochrome (cyt) c can uncouple from the respiratory chain following mitochondrial stress and catalyze lipid peroxidation. Accumulating evidence shows that this phenomenon impairs mitochondrial respiratory function and also initiates the apoptotic cascade. Therefore, under certain conditions a pharmacological approach...

journal_title：Biochemical and biophysical research communications

authors： Yin H,Vergeade A,Shi Q,Zackert WE,Gruenberg KC,Bokiej M,Amin T,Ying W,Masterson TS,Zinkel SS,Oates JA,Boutaud O,Roberts LJ 2nd

更新日期：2012-06-29 00:00:00

abstract：:Oxidized low-density lipoprotein (ox-LDL) is a critical mediator of atherogenesis. Macrophage uptake of ox-LDL and their subsequent development into foam cells is the principal event in atherosclerosis. Interleukin-1β (IL-1β), a prototypic multifunctional cytokine involved in inflammation, has an important effect on t...

journal_title：Biochemical and biophysical research communications

authors： Jiang Y,Wang M,Huang K,Zhang Z,Shao N,Zhang Y,Wang W,Wang S

更新日期：2012-08-24 00:00:00

abstract：:The present study revealed that low density lipoprotein (LDL) obtained from rabbits fed highly purified eicosapentaenoic acid-ethyl ester (EPA-E) (EPA-LDL) was significantly less susceptible to oxidative modification catalyzed by Cu2+ as compared to LDL from rabbits fed a normal diet (control LDL). In a comparison of ...

journal_title：Biochemical and biophysical research communications

authors： Saito H,Chang KJ,Tamura Y,Yoshida S

更新日期：1991-02-28 00:00:00

abstract：:In the early postnatal period, cerebellar granule cells exhibit an activity-dependent downregulation of a set of immaturation genes involved in cell growth and migration and are shifted to establishment of a mature network formation. Through the use of a granule cell culture and both pharmacological and RNA interferen...

journal_title：Biochemical and biophysical research communications

authors： Okazawa M,Abe H,Nakanishi S

更新日期：2016-05-13 00:00:00

abstract：:Inactivated vaccines are widely used for prevention of viral disease. Both humoral and cellular immune responses have been shown to play important roles in the control and clearance of virus infections. CpG motif containing oligodeoxynucleotides (ODN) have recently gained considerable interest and been used as vaccine...

journal_title：Biochemical and biophysical research communications

authors： Liang H,Xiao X,Zhang X,Hu Q,Yang Y,Cen S,Deng X,Sheng W

更新日期：2019-04-02 00:00:00

abstract：:Heavy water (D2O) has been used as a putative inhibitor of the plasma membrane H(+)-ATPase and the plasma membrane redox system. Concentrations above 50% D2O inhibited H+ secretion and the plasma membrane redox system of Zea mays L. roots. Inhibition of H+ secretion by vanadate was reduced in presence of D2O. The plas...

journal_title：Biochemical and biophysical research communications

authors： Döring O,Böttger M

更新日期：1992-01-31 00:00:00

abstract：:Intranuclear inclusions have been observed in the brains of patients affected with Huntington's disease (HD). Neuro 2A cells that transiently expressed HD exon 1 bearing 74 glutamine repeats linked to the green fluorescent protein (GFP) and the nuclear localization sequence (NLS) contained aggregates in nuclei. The ag...

journal_title：Biochemical and biophysical research communications

authors： Hazeki N,Tsukamoto T,Yazawa I,Koyama M,Hattori S,Someki I,Iwatsubo T,Nakamura K,Goto J,Kanazawa I

更新日期：2002-06-07 00:00:00

abstract：:Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme that catalyzes the synthesis of ADP-ribose polymers from NAD(+). The function of PARP-1 is related to important nuclear processes including DNA repair and transcription. Previous studies demonstrated a specific physical interaction between PARP-1 and the trans...

journal_title：Biochemical and biophysical research communications

authors： Oei SL,Shi Y

更新日期：2001-06-08 00:00:00

abstract：:Britannin (Bri), isolated from Inula aucheriana, is a sesquiterpene lactone (SL), a class of secondary metabolites. Previous studies have suggested the anti-cancer potential of Bri; however, the molecular mechanism remains elusive. The present study investigated the effects of Bri on liver cancer progression. Our find...

journal_title：Biochemical and biophysical research communications

authors： Cui YQ,Liu YJ,Zhang F

更新日期：2018-03-11 00:00:00

abstract：:The human pterin-4 alpha-carbinolamine dehydratase (PCD)/dimerization cofactor for the transcription factor HNF-1 alpha is a bifunctional protein proposed to be involved in entirely different biochemical functions. We previously established the complete amino acid sequence for the human liver PCD and subsequently isol...

journal_title：Biochemical and biophysical research communications

authors： Thöny B,Neuheiser F,Blau N,Heizmann CW

更新日期：1995-05-25 00:00:00

abstract：:We established two monoclonal antibodies (mAbs) which specifically recognize human 'functionally inactive' recombinant IL-18, and IL-18 protein polymorphism was examined using human monocytes and macrophages (M phi). In 6 day GM-CSF-treated M phi, an 'inactive' IL-18-recognizing mAb 21 detected the IL-18 proform (24 k...

journal_title：Biochemical and biophysical research communications

authors： Kikkawa S,Matsumoto M,Shida K,Fukumori Y,Toyoshima K,Seya T

更新日期：2001-02-23 00:00:00

abstract：:We have previously identified the region containing transcriptional enhancer in mouse immunoglobulin heavy chain (IgH) gene as an initiation region of DNA replication. The octamer sequence therein has been found to be essential for initiation of DNA replication as well as for transcription. Octamer-binding protein fam...

journal_title：Biochemical and biophysical research communications

authors： Ogawa N,Ariga H,Iguchi-Ariga SM

更新日期：1994-05-16 00:00:00

abstract：:Human platelets have been shown to contain a Ca++- and CoA-independent transacylase enzyme that catalyzes the transfer of arachidonic acid from phosphatidylcholine (PC) to lysoplasmenylethanolamine. It has been suggested that this route may represent a major source for released arachidonic acid in stimulated platelets...

journal_title：Biochemical and biophysical research communications

authors： Mahadevappa VG

更新日期：1987-04-29 00:00:00

abstract：:In the process of cardiac remodeling, connective tissue growth factor (CTGF/CCN2) is secreted from cardiac myocytes. Though CTGF is well known to promote fibroblast proliferation, its pathophysiological effects in cardiac myocytes remain to be elucidated. In this study, we examined the biological effects of CTGF in ra...

journal_title：Biochemical and biophysical research communications

authors： Hayata N,Fujio Y,Yamamoto Y,Iwakura T,Obana M,Takai M,Mohri T,Nonen S,Maeda M,Azuma J

更新日期：2008-05-30 00:00:00

abstract：:Pyruvate dehydrogenase kinase isoform 4 (PDK4) is upregulated by starvation in many tissues of the body during starvation. This causes inactivation of the pyruvate dehydrogenase complex which blocks pyruvate oxidation and conserves lactate and alanine for gluconeogenesis. Enhanced PDK4 expression may be caused by the ...

journal_title：Biochemical and biophysical research communications

authors： Wu P,Peters JM,Harris RA

更新日期：2001-09-21 00:00:00

abstract：:Ultraweak luminescence (uwCL) was coupled with electron spin resonance to study the reactions of 3 heterocyclic compounds (tryptophan, serotonin and imidazole) with peroxynitrite at pH 8.7. Tryptophan and serotonin reacted with emission of a flash peak of light (5 s) followed by a long-living light emission of +/- 80 ...

journal_title：Biochemical and biophysical research communications

authors： Mouithys-Mickalad A,Kohnen S,Deby C,Noels AF,Lamy M,Deby-Dupont G

更新日期：1999-06-07 00:00:00

abstract：:We previously showed that beta-defensin-1 (BD-1), an anti-microbial peptide, is up-regulated during progressive hyperglycemia in the kidneys of the GK rat [R.A. Page, C.A. Morris, J.D. Williams, C.J. von Ruhland, A.N. Malik, Isolation of diabetes-associated kidney genes using differential display, Biochem. Biophys. Re...

journal_title：Biochemical and biophysical research communications

authors： Malik AN,Al-Kafaji G

更新日期：2007-02-09 00:00:00

abstract：:Exposure to silica has been associated with progressive pulmonary inflammation and fibrosis. While the fibroblasts play an important role in the pathogenesis of silicosis, the direct interaction between silica and fibroblasts is poorly understood. We observed that silica particles stimulated intracellular ROS generati...

journal_title：Biochemical and biophysical research communications

authors： Cho YJ,Seo MS,Kim JK,Lim Y,Chae G,Ha KS,Lee KH

更新日期：1999-09-07 00:00:00

abstract：:Podocytes are the major site of vascular endothelial growth factor (VEGF) production in the kidney, and up-regulation of VEGF plays a critical role in the progression of diabetic nephropathy. Using a differentiated mouse podocyte cell line, we investigated the roles of protein kinase C (PKC) and extracellular signal-r...

journal_title：Biochemical and biophysical research communications

authors： Hoshi S,Nomoto K,Kuromitsu J,Tomari S,Nagata M

更新日期：2002-01-11 00:00:00

abstract：:Intestinal epithelial cells participate in an acute phase response (APR) by responding to cytokines and by expressing acute phase protein genes. We hypothesized that butyrate, a fermentation product of the bacterial intestinal flora with deacetylase activity, affects the APR in intestinal epithelial cells. Sodium buty...

journal_title：Biochemical and biophysical research communications

authors： Désilets A,Gheorghiu I,Yu SJ,Seidman EG,Asselin C

更新日期：2000-09-24 00:00:00

abstract：:In this investigation, the activities of five enzymes (catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, glucose-6-dehydrogenase) involved in oxygen radical (OR)-detoxification and antioxidative defense were measured in conjunction with an index of lipid peroxidation in major prostatic lob...

journal_title：Biochemical and biophysical research communications

authors： Ghatak S,Ho SM

更新日期：1996-05-15 00:00:00

abstract：:In order to identify the mechanism by which cyclic AMP stimulates expression of the human renin gene (REN), the effect of forskolin was tested in transient expression analyses of REN 5'-flanking DNA-chloramphenicol acetyltransferase (CAT) reporter gene constructs in secondary cultures of human chorio-decidual cells, a...

journal_title：Biochemical and biophysical research communications

authors： Smith DL,Morris BJ,Do YS,Law RE,Shaw KJ,Hseuh WA

更新日期：1994-04-15 00:00:00

abstract：:Homeobox gene expression in osteoblast-like cells was investigated using the polymerase chain reaction (PCR). A total of 13 homeobox genes was detected in U-2 OS (human osteosarcoma) and MC3T3-E1 (mouse osteoblast) cells by sequencing cloned PCR products. Using specific primers, a different pattern of Hox gene express...

journal_title：Biochemical and biophysical research communications

authors： Kloen P,Visker MH,Olijve W,van Zoelen EJ,Boersma CJ

更新日期：1997-04-17 00:00:00

abstract：:A truncated form of 24kDa FGF-2 consisting of 86 NH(2)-terminal amino acids (ATE+31) inhibits cell migration in vitro and tumor development and angiogenesis in vivo. Focal adhesion kinase (FAK) is phosphorylated on tyrosine and serine sites after cell stimulation by growth factors. This study examined the effect of AT...

journal_title：Biochemical and biophysical research communications

authors： Lin AH,Eliceiri BP,Levin EG

更新日期：2009-05-08 00:00:00

abstract：:Recent reports have shown that the endoplasmic reticulum (ER) stress is relevant to the pathogenesis of Alzheimer disease. Following the amyloid cascade hypothesis, we therefore attempted to investigate the effects of ER stress on amyloid-beta peptide (Abeta) generation. In this study, we found that ER stress altered ...

journal_title：Biochemical and biophysical research communications

authors： Kudo T,Okumura M,Imaizumi K,Araki W,Morihara T,Tanimukai H,Kamagata E,Tabuchi N,Kimura R,Kanayama D,Fukumori A,Tagami S,Okochi M,Kubo M,Tanii H,Tohyama M,Tabira T,Takeda M

更新日期：2006-06-02 00:00:00

abstract：:Production of endothelin-1 in the cultured neonatal rat cardiac myocytes was investigated. Studies on the cultured cardiac myocytes with reverse transcription-polymerase chain reaction followed by Southern hybridization indicated that mRNA of ET-1(preproET-1 mRNA) was expressed by cardiac myocytes. ET-1 polypeptide wa...

journal_title：Biochemical and biophysical research communications

authors： Suzuki T,Kumazaki T,Mitsui Y

更新日期：1993-03-31 00:00:00

abstract：:Human thymidine phosphorylase (dThdPase) is thought to be identical to an angiogenesis factor, platelet-derived endothelial cell growth factor (PD-ECGF). However, the whole amino acid sequence of dThdPase is still unknown. N-terminal amino acid sequencing of dThdPase isolated from human placenta gave the sequence Ac-A...

journal_title：Biochemical and biophysical research communications

authors： Miyadera K,Dohmae N,Takio K,Sumizawa T,Haraguchi M,Furukawa T,Yamada Y,Akiyama S

更新日期：1995-07-26 00:00:00