Abstract:
:Recent advances in mass spectrometry have expanded our knowledge of lipids and lipid metabolic pathways involved in many (patho)physiological events. Targeted and non-targeted lipidomics are powerful analytical strategies with distinct features, and a combination of these two approaches is often employed to maximize the coverage of lipid species detected and quantified in complex biological matrices. This review briefly summarizes the applications of targeted and non-targeted lipidomics, mainly focusing on electrospray ionization-liquid chromatography-tandem mass spectrometry (ESI-LC-MS/MS), along with recent technical advances in the field. Current limitations and challenges in lipidomics and possible solutions are also discussed.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Lee HC,Yokomizo Tdoi
10.1016/j.bbrc.2018.03.081subject
Has Abstractpub_date
2018-10-07 00:00:00pages
576-581issue
3eissn
0006-291Xissn
1090-2104pii
S0006-291X(18)30567-9journal_volume
504pub_type
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