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Sodium ion modulates collagen types in human fibroblastic cells in culture.

Abstract：

:Collagen synthesis in human fibroblasts was increased by the presence of 0.1M excess NaCl in the culture medium. Type analysis of the collagen produced by the cells showed the increase in the ratio of type III collagen to the total collagen. Similar NaCl effects were observed in several cell lines derived from different tissues. Sodium ion but not chlorine ion seems to be essential to the modulation of collagen production by the cells, because addition of CH3COONa induced similar effects but addition of KCl instead of NaCl resulted in specific inhibition of the collagen production.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hata R,Sunada H,Nagai Y

doi

10.1016/0006-291x(83)91577-2

subject

Has Abstract

pub_date

1983-11-30 00:00:00

pages

313-8

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(83)91577-2

journal_volume

117

pub_type

杂志文章

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