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Modulation of nucleotide pyrophosphatase in plasmacytoma cells.

Abstract：

:The effect of glucocorticoid hormones on the protein responsible for both nucleotide pyrophosphatase (EC 3.6.1.9) and alkaline phosphodiesterase I (EC 3.1.4.1) activities was examined in murine MOPC 315 plasmacytoma cells. Incubation of these cells with dexamethasone resulted in parallel increases in pyrophosphatase and phosphodiesterase specific activities. The incorporation of [3H]mannose into N-linked oligosaccharide precursors was also analyzed in cells following hormone modulation. In cells treated for 36 hours or cultured continuously with dexamethasone, the resulting increase in enzyme specific activities was accompanied by a decrease in [3H]mannose incorporation, consistent with the hypothesis that in some cell types, nucleotide pyrophosphatase activity is involved in the regulation of glycoprotein synthesis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Rebbe NF,Hickman S

doi

10.1016/0006-291x(91)91613-h

subject

Has Abstract

pub_date

1991-03-15 00:00:00

pages

637-44

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(91)91613-H

journal_volume

175

pub_type

杂志文章

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