Abstract：
:The oral mucosa is an active though poorly understood immunological site. Using an experimental animal system involving antigen priming into the oral mucosa of transgenic mice expressing T cell receptor (TCR) for a peptide antigen of hen-egg lysozyme (HEL), the expression of six chemokine receptors and seven chemokine ligands were studied before and after antigen exposure. Within 24h of local antigen priming, the expression of three chemokine receptor genes (CCR3, CCR5, and CCR7) and three chemokine ligand genes (CCL12, CCL19, and CCL25) were significantly upregulated. These included chemokines known to be responsible for the trafficking of T cells and other leukocytes into tissue sites. Additionally, expression of the chemokine ligand gene, CCL25 (thymus-expressed chemokine [TECK]), which has been linked to T cell migration and/or local T cell development in the intestine, was also markedly elevated in buccal epithelia after antigen exposure. These findings define a process of selective activation of proinflammatory chemokines and/or their receptors following local antigen exposure, and they provide the first evidence, indicating that this may be accompanied by in situ development of T cells in oral tissues.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Otten K,Dragoo J,Wang HC,Klein JRdoi
10.1016/s0006-291x(03)00533-3subject
Has Abstractpub_date
2003-04-25 00:00:00pages
36-40issue
1eissn
0006-291Xissn
1090-2104pii
S0006291X03005333journal_volume
304pub_type
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