The soluble metalloendoprotease required in myoblast fusion remains intracellular.

abstract：:A protein of M(r) 59,000 (p59) was recently cloned and identified as a Heat shock protein Binding Immunophilin (p59/HBI). It participates to the heterooligomeric, non-DNA binding form of steroid receptors, in association with the heat shock protein of M(r) 90,000 (hsp90). It binds the immunosuppressants FK506 and rapa...

journal_title：Biochemical and biophysical research communications

authors： Le Bihan S,Renoir JM,Radanyi C,Chambraud B,Joulin V,Catelli MG,Baulieu EE

更新日期：1993-09-15 00:00:00

abstract：:Rat mast cell protease of type 1 (RMCP1) is a specific marker of connective tissue mast cells selectively occurring in some tissues, e.g., the tongue. Its amino acid sequence is known (Le Trong et al., Biochem. 1987, 26, 6988-6994) but not the corresponding nucleotide sequence. Amplification of mRNAs from rat tongue w...

journal_title：Biochemical and biophysical research communications

authors： Rouleau A,Garbarg M,Schwartz JC,Ruat M

更新日期：1994-03-15 00:00:00

abstract：:Prostate cancer has become one of commonest urologic tumors in male. In recent years, miRNAs are continually attracting attentions of researchers for their special regulatory function in human cancers. Previous study has revealed that miR-410 acts as a biomarker for the diagnosis of prostate cancer. Whereas, the speci...

journal_title：Biochemical and biophysical research communications

authors： Zhang Y,Zhang D,Lv J,Wang S,Zhang Q

更新日期：2018-09-18 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase (CCaMK) has been shown to play important roles in brassinosteroid (BR)-induced antioxidant defense and enhancing the tolerance of plants to drought stress. The autophosphorylation of CCaMK is a key step for the activation of CCaMK, thus promoting substrate phosphorylation. H...

journal_title：Biochemical and biophysical research communications

authors： Liu L,Han T,Liu W,Han G,Di P,Yu X,Yan J,Zhang A

更新日期：2020-05-07 00:00:00

abstract：:This report describes a procedure to generate enzymatically active, isolated HIV RNase H domain. In contrast to previously described preparations, the RNA cleavage activity of the untagged RNase H domain was surprisingly similar to that of the full-length HIV-RT protein. Signature cleavages at 18 and 9 nucleotides dow...

journal_title：Biochemical and biophysical research communications

authors： Hang JQ,Rajendran S,Yang Y,Li Y,In PW,Overton H,Parkes KE,Cammack N,Martin JA,Klumpp K

更新日期：2004-04-30 00:00:00

abstract：:ABCA1 on the cell surface and in endosomes plays an essential role in the cell-mediated lipidation of apoA-I to form nascent HDL. Our previous studies of transgenic mice overexpressing ABCA1 suggested that ABCA1 in the liver plays a major role in regulating plasma HDL levels. The site of function of ABCA1 in the polar...

journal_title：Biochemical and biophysical research communications

authors： Neufeld EB,Demosky SJ Jr,Stonik JA,Combs C,Remaley AT,Duverger N,Santamarina-Fojo S,Brewer HB Jr

更新日期：2002-10-04 00:00:00

abstract：:The effects of endothelins (ETs) on the production of stromelysins, a sub-family of matrix metalloproteinases, were examined in cultured astrocytes. The treatment of cultured rat astrocytes with ET-1 increased stromelysin-1 mRNA levels, while stromelysin-2 and -3 mRNAs were not affected. Immunocytochemical observation...

journal_title：Biochemical and biophysical research communications

authors： Koyama Y,Tanaka K

更新日期：2008-07-11 00:00:00

abstract：:Methamphetamine induces several cardiac dysfunctions, which leads to arrhythmia, cardiac failure and sudden cardiac death. Although these cardiac alterations elicited by methamphetamine were thought to be due to an indirect action of methamphetamine, namely, an excessive catecholamine release from synaptic terminals, ...

journal_title：Biochemical and biophysical research communications

authors： Sugimoto K,Okamura K,Tanaka H,Takashima S,Ochi H,Yamamoto T,Matoba R

更新日期：2009-12-25 00:00:00

abstract：:The production of 1 alpha,25-dihydroxyvitamin D3 is known to be down regulated by 1 alpha,25-dihydroxyvitamin D3 itself. It was recently shown that liver mitochondrial sterol 27-hydroxylase CYP27, present also in kidney, catalyzes 1 alpha-hydroxylation of 25-hydroxyvitamin D3. Treatment of vitamin D-deficient rats wit...

journal_title：Biochemical and biophysical research communications

authors： Axén E,Postlind H,Wikvall K

更新日期：1995-10-04 00:00:00

abstract：:The retinoblastoma tumor suppressor protein (RB) is inactivated in a majority of cancers. RB restricts cell proliferation by inhibiting the E2F family of transcription factors. The current model for RB/E2F function describes its role in regulating transcription at gene promoters. Whether the RB or E2F proteins might p...

journal_title：Biochemical and biophysical research communications

authors： Ahlander J,Bosco G

更新日期：2009-07-03 00:00:00

abstract：:Lanosterol was converted to a 14-demethylated metabolite, 4,4-dimethylzymosterol by Saccharomyces cerevisiae microsomes. This metabolism was mediated by a cytochrome P-450 (P-450/14DM). However, a reconstituted system consisting of P-450/14DM and its reductase converted lanosterol to the 14-desaturated derivative of 4...

journal_title：Biochemical and biophysical research communications

authors： Aoyama Y,Yoshida Y

更新日期：1986-01-29 00:00:00

abstract：:Spinal and bulbar muscular atrophy (SBMA) is one of a group of human inherited neurodegenerative diseases caused by polyglutamine expansion. There is increasing evidence that generation of truncated proteins containing an expanded polyglutamine tract may be an important step in the pathogenesis of these disorders. We ...

journal_title：Biochemical and biophysical research communications

authors： Kobayashi Y,Miwa S,Merry DE,Kume A,Mei L,Doyu M,Sobue G

更新日期：1998-11-09 00:00:00

abstract：:Imatinib mesylate, commercially known as Gleevec/Glivec, is the first targeted anticancer drug that inhibits activity of the tyrosine kinases, c-ABL, c-KIT, and PDGFR. A number of studies have shown that treatment with imatinib mesylate elicits extracellular signal-related kinase (ERK) activation, which, in turn, has ...

journal_title：Biochemical and biophysical research communications

authors： Lee J,Ko J,Kim HJ,Im H,Kim EJ,Yi JY

更新日期：2018-12-02 00:00:00

abstract：:Recent identification of intracellular proteins that bind ammodytoxin (calmodulin, 14-3-3 proteins, and R25) suggests that this snake venom presynaptically active phospholipase A(2) acts intracellularly. As these ammodytoxin acceptors are cytosolic and mitochondrial proteins, the toxin should be able to enter the cyto...

journal_title：Biochemical and biophysical research communications

authors： Petrovic U,Sribar J,Paris A,Rupnik M,Krzan M,Vardjan N,Gubensek F,Zorec R,Krizaj I

更新日期：2004-11-19 00:00:00

abstract：:Blockage of either nuclear factor-kappaB (NF-kappaB) or Akt sensitizes cancer cells to TNF-induced apoptosis. In this study, we investigated the undetermined effect of concurrent blockage of these two survival pathways on TNF-induced cytotoxicity in lung cancer cells. The results show that Akt contributes to TNF-induc...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Chen W,Lin Y

更新日期：2007-04-13 00:00:00

abstract：:We have examined the effect of hypoxia and nutrient depletion on the growth of human neuroblastoma cells with normal or enhanced expression of the N-myc oncogene. The combination of both conditions reduced the growth of neuroblastoma cells with normal N-myc expression. However, this effect was much more pronounced in ...

journal_title：Biochemical and biophysical research communications

authors： Rössler J,Schwab M,Havers W,Schweigerer L

更新日期：2001-02-23 00:00:00

abstract：:The perchloric acid-soluble protein (PSP) is an endoribonuclease and on the basis of sequence similarity has been assigned to the YjgF/YER057c/UK114 family. These family members are ubiquitous and highly conserved in evolution, and participate in regulating basic cellular metabolism. Here we present the 2.1A crystal s...

journal_title：Biochemical and biophysical research communications

authors： Zhang HM,Gao Y,Li M,Chang WR

更新日期：2010-06-18 00:00:00

abstract：:We examined the expression of a Caenorhabditis elegans (C. elegans) elav-like gene, which we designated elr-1. The elr-1 gene encodes a predicted 456-amino-acid protein containing three putative RNA-binding domains and belongs to the ELAV family, which is functionally involved in neuronal differentiation. Northern blo...

journal_title：Biochemical and biophysical research communications

authors： Fujita M,Kawano T,Ohta A,Sakamoto H

更新日期：1999-07-14 00:00:00

abstract：:It is well known that some intestinal bacteria, such as Escherichia coli, can produce a remarkable amount of molecular hydrogen (H(2)). Although the antioxidant effects of H(2) are well documented, the present study examined whether H(2) released from intestinally colonized bacteria could affect Concanavalin A (ConA)-...

journal_title：Biochemical and biophysical research communications

authors： Kajiya M,Sato K,Silva MJ,Ouhara K,Do PM,Shanmugam KT,Kawai T

更新日期：2009-08-21 00:00:00

abstract：:In lens, αβγ-crystallins accounting for ∼90% of ocular proteins with concentrations >400 mg/ml need to remain soluble for the whole life-span and their aggregation can lead to cataract. Mysteriously, despite being a metabolically-quiescent organ, lens maintains ATP concentrations of 3-7 mM. Very recently, ATP was prop...

journal_title：Biochemical and biophysical research communications

authors： He Y,Kang J,Song J

更新日期：2020-06-11 00:00:00

abstract：:Photoinactivation is a common phenomenon in bioluminescence ctenophore photoproteins (e.g mnemiopsin, berovin and BfosPP) with still unknown mechanism. The activity of coelenterate photoproteins (e.g aequorin), which has high structural similarity with ctenophore photoproteins, is not affected by light. Recently, we h...

journal_title：Biochemical and biophysical research communications

authors： Pashandi Z,Molakarimi M,Mohseni A,Sajedi RH,Taghdir M,Naderi-Manesh H

更新日期：2017-08-19 00:00:00

abstract：:Herpes simplex virus-1 (HSV-1) glycoprotein E (gE) is a multifunctional protein capable of both binding the Fc portion of IgG and mediating cell-to-cell spread of HSV-1. Here we report that the domain on gE involved in IgG binding is distinct from the domain involved in mediating cell-to-cell spread. To do this we hav...

journal_title：Biochemical and biophysical research communications

authors： Weeks BS,Sundaresan P,Nagashunmugam T,Kang E,Friedman HM

更新日期：1997-06-09 00:00:00

abstract：:We have sequenced all mitochondrial tRNA genes from a patient with chronic progressive external ophthalmoplegia (CPEO) and mitochondrial myopathy, who had no detectable large mtDNA deletions. Direct sequencing failed to detect previously reported mutations and showed a heteroplasmic mutation at nucleotide 12,276 in th...

journal_title：Biochemical and biophysical research communications

authors： Cardaioli E,Da Pozzo P,Radi E,Dotti MT,Federico A

更新日期：2005-02-18 00:00:00

abstract：:We previously reported that Ca2+/calmodulin-dependent protein kinase II (CaMKII) is inhibited by S-nitrosylation of Cys6 in cells. Herein, we show that polysulfidation of CaMKII at Cys6 limits its enzyme activity following reactive sulfur species (RSS) stimulus. In vitro incubation of CaMKII with the RSS donor, Na2S4,...

journal_title：Biochemical and biophysical research communications

authors： Araki S,Takata T,Tsuchiya Y,Watanabe Y

更新日期：2019-01-08 00:00:00

abstract：:Alpha-Galactosidase, the product of the melA gene, was purified from a strain of Escherichia coli harboring a plasmid carrying melA, which over-produced the alpha-galactosidase. An apparent molecular weight was determined to be 50 kDa. The amino acid composition of this enzyme was determined. The result indicates that...

journal_title：Biochemical and biophysical research communications

authors： Nagao Y,Nakada T,Imoto M,Shimamoto T,Sakai S,Tsuda M,Tsuchiya T

更新日期：1988-02-29 00:00:00

abstract：:Human PTK7 is a defective receptor protein tyrosine kinase and its expression is upregulated in various cancers including colorectal carcinomas. To determine whether PTK7 functions in angiogenesis, we have expressed and purified the extracellular domain of PTK7 (soluble PTK7; sPTK7) as a decoy receptor to counteract t...

journal_title：Biochemical and biophysical research communications

authors： Shin WS,Maeng YS,Jung JW,Min JK,Kwon YG,Lee ST

更新日期：2008-07-11 00:00:00

abstract：:Hypothetical lambda protein ORF314 shows significant homology with the carboxyl end of phage T4 tail-fiber protein gp37. Homology can also be demonstrated between hypothetical lambda protein ORF194 and a fragment of bacteriophage T4 protein gp38. This sequence homology is also reflected in the genomic sequences of the...

journal_title：Biochemical and biophysical research communications

authors： George DG,Yeh LS,Barker WC

更新日期：1983-09-30 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase II (CaM KII) is thought to be involved in the majority of the neuronal functions mediated by intracellular free Ca(2+), and has been implicated in long-term potentiation, learning, and memory. In this work, we have examined in detail the RNA expression pattern for the Drosop...

journal_title：Biochemical and biophysical research communications

authors： Rachidi M,Lopes C,Takamatsu Y,Ohsako S,Benichou JC,Delabar JM

更新日期：1999-07-14 00:00:00

abstract：:GTP cyclohydrolase I is the rate-limiting enzyme in the de novo synthesis pathway of tetrahydrobiopterin which is an essential cofactor for all NO synthase isoforms. The expression of GTP cyclohydrolase I is regulated on a transcriptional level by a variety of cytokines like interleukin 1beta or tumor necrosis factor ...

journal_title：Biochemical and biophysical research communications

authors： Lapize C,Plüss C,Werner ER,Huwiler A,Pfeilschifter J

更新日期：1998-10-29 00:00:00

abstract：:Electrophoretic analysis of murine anterior pituitary extract revealed five major proteins of Mr 13,000-18,000 (designated P13, P14, P16, P17, and P18 according to Mr), three of which, P16, P17, and P18, were markedly influenced by estradiol benzoate and perphenazine in a manner similar to that of growth hormone, and ...

journal_title：Biochemical and biophysical research communications

authors： Sinha YN,Jacobsen BP

更新日期：1988-10-14 00:00:00