Reactive sulfur species impair Ca2+/calmodulin-dependent protein kinase II via polysulfidation.

abstract：:Pluripotent embryonic stem (ES) cells are the most versatile cells, with the potential to differentiate into all types of cell lineages including neural precursor cells (NPCs), which can be expanded in large numbers for significant periods of time to provide a reliable cell source for transplantation in neurodegenerat...

journal_title：Biochemical and biophysical research communications

authors： Xu H,Fan X,Wu X,Tang J,Yang H

更新日期：2005-01-07 00:00:00

abstract：:We have identified a genomic DNA fragment, using the PCR method with degenerate oligonucleotide primers which contain the conserved sequence of the RING finger domain. Using the DNA fragment as a probe, a novel cDNA was cloned from human and mouse testis. The cDNA had a domain structure of the typical RING-B box-coile...

journal_title：Biochemical and biophysical research communications

authors： Orimo A,Yamagishi T,Tominaga N,Yamauchi Y,Hishinuma T,Okada K,Suzuki M,Sato M,Nogi Y,Suzuki H,Inoue S,Yoshimura K,Shimizu Y,Muramatsu M

更新日期：2000-09-16 00:00:00

abstract：:Calcineurin is a Ca2+ calmodulin dependent protein phosphatase which has an important role in the control of intracellular Ca2+ signalling. The protein is a heterodimer of one catalytic (CnA) subunit and one regulatory (CnB) subunit. As suggested by the protein sequence and confirmed by the crystallographic structure,...

journal_title：Biochemical and biophysical research communications

authors： Guerini D

更新日期：1997-06-18 00:00:00

abstract：:Advanced glycation end products (AGEs) are harmful compounds generated by nonspecific glycation of proteins and lipids. The accumulation of AGEs is associated with various diseases, including breast cancer. AGEs have been shown to promote a breast cancer cell line by enhancing proliferation, invasion and migration. In...

journal_title：Biochemical and biophysical research communications

authors： Lee KJ,Yoo JW,Kim YK,Choi JH,Ha TY,Gil M

更新日期：2018-01-15 00:00:00

abstract：:Stimulation of DNA synthesis by EGF was compared in cultured periportal and perivenous hepatocyte populations. Periportal hepatocytes responded to EGF more sensitive (IC50-values 20 vs 75 ng/ml) and with a higher maximal stimulation (420 vs 290%) than perivenous hepatocytes with respect to both [3H]thymidine incorpora...

journal_title：Biochemical and biophysical research communications

authors： Gebhardt R,Jonitza D

更新日期：1991-12-31 00:00:00

abstract：BACKGROUND:DMSO is routinely infused together with hematopoietic cells in patients undergoing myeloablative therapy and was recently found to inhibit smooth muscle cells proliferation and arterial thrombus formation in the mouse by preventing tissue factor (TF), a key activator of the coagulation cascade. This study wa...

journal_title：Biochemical and biophysical research communications

authors： Asmis L,Tanner FC,Sudano I,Lüscher TF,Camici GG

更新日期：2010-01-22 00:00:00

abstract：:The role of osteoblasts in inducing the proliferation and differentiation of bone marrow cells was examined. Conditioned medium obtained from mouse osteoblastic cell (MC3T3-E1) cultures stimulated colony formation of mouse bone marrow cells (CSF) and differentiation of mouse myeloid leukemia cells (M1) into macrophage...

journal_title：Biochemical and biophysical research communications

authors： Shiina-Ishimi Y,Abe E,Tanaka H,Suda T

更新日期：1986-01-14 00:00:00

abstract：:Several preclinical studies have revealed antidepressant and anxiolytic-like effect of 5-HT3 receptor antagonists. In our earlier study, we have reported the antidepressive-like effect of 3-methoxy-N-p-tolylquinoxalin-2-carboxamide (QCM-4) in obese mice subjected to chronic stress. The present study deals with the bio...

journal_title：Biochemical and biophysical research communications

authors： Kurhe Y,Mahesh R,Devadoss T

更新日期：2015-01-02 00:00:00

abstract：:Human erythrocyte acetylcholinesterase is an amphipathic enzyme whose hydrophobic membrane-binding domain can be selectively labeled with a lipophilic photoreagent and removed by digestion with papain. In this paper we demonstrate that methanolysis releases covalently bound fatty acids from the hydrophobic domain and ...

journal_title：Biochemical and biophysical research communications

authors： Roberts WL,Rosenberry TL

更新日期：1985-12-17 00:00:00

abstract：:We previously reported that novel targeted "hybrid peptide" in which epidermal growth factor receptor (EGFR) binding peptide was conjugated with lytic-type peptide had selective cytotoxic activity to EGFR expressing cancer cell lines, and in vivo analysis revealed that this EGFR-lytic peptide displayed significant ant...

journal_title：Biochemical and biophysical research communications

authors： Tada N,Horibe T,Haramoto M,Ohara K,Kohno M,Kawakami K

更新日期：2011-04-08 00:00:00

abstract：:Neuregulin1 (NRG1) is a growth factor that signals through the interaction of the epidermal growth factor (EGF)-like domain with ErbB receptors. An immunoglobulin (Ig)-like domain is contained together with EGF-like domain in the ectodomain of some isoforms generated by alternative splicing, but its role in NRG1 signa...

journal_title：Biochemical and biophysical research communications

authors： Eto K,Eda K,Kanemoto S,Abe S

更新日期：2006-11-17 00:00:00

abstract：:Human prostatic acid phosphatase (hPAP) is intensely expressed in epithelial cells of the prostate gland following puberty. Its regulatory regions were analyzed in transgenic mice and cell line transfections, in order to clarify the mechanisms of tissue-specific gene expression. A construct containing the sequence of ...

journal_title：Biochemical and biophysical research communications

authors： Shan J,Porvari K,Kivinen A,Patrikainen L,Halmekytö M,Jänne J,Vihko P

更新日期：2003-11-28 00:00:00

abstract：:An ubiquitous biochemical pathway known to synthesize nitric oxide (NO) from L-arginine has been identified in many cell types. Recent studies indicate that besides activating soluble guanylate cyclase NO is likely to have effects unrelated to the known signal transduction pathway. Activation of the soluble NO synthas...

journal_title：Biochemical and biophysical research communications

authors： Dimmeler S,Brüne B

更新日期：1991-08-15 00:00:00

abstract：:Osteoclasts together with osteoblasts play pivotal roles in bone remodeling. Aberrations in osteoclast differentiation and activity contribute to osteopenic disease. Osteoclasts differentiate from monocyte/macrophage progenitors, a process that is initiated by the interaction between receptor activator of NF-κB (RANK)...

journal_title：Biochemical and biophysical research communications

authors： Wisutsitthiwong C,Buranaruk C,Pudhom K,Palaga T

更新日期：2011-11-18 00:00:00

abstract：:Neuropeptide Y (NPY) is known to induce robust feeding through the action of NPY receptors in the hypothalamus. Among the subtypes of NPY receptors, Y(1) receptors may play a key role in feeding regulation. In the present study, we demonstrated that a novel Y(1) antagonist, J-104870, shows high selectivity and potency...

journal_title：Biochemical and biophysical research communications

authors： Kanatani A,Kanno T,Ishihara A,Hata M,Sakuraba A,Tanaka T,Tsuchiya Y,Mase T,Fukuroda T,Fukami T,Ihara M

更新日期：1999-12-09 00:00:00

abstract：:4alpha-Carbinolamine dehydratase is a bifunctional protein involved in the regeneration of tetrahydrobiopterin during the hydroxylation of the aromatic amino acids. It is also a dimerization cofactor of HNF1 and therefore is believed to function as part of the hepatic gene transcription system. In view of the recent d...

journal_title：Biochemical and biophysical research communications

authors： Lei XD,Woodworth CD,Johnen G,Kaufman S

更新日期：1997-09-18 00:00:00

abstract：:The growth of DU-145 human prostate carcinoma cells is reduced to 50% of control by 1 X 10(-6) M to 2 X 10(-6) M selenium and to 2% of control at 10(-4)M selenium. These cells show greater sensitivity to inhibition of growth or DNA synthesis by selenium than human W1-38 and HeLa cells and mouse mammary tumor cells. It...

journal_title：Biochemical and biophysical research communications

authors： Webber MM,Perez-Ripoll EA,James GT

更新日期：1985-07-31 00:00:00

abstract：:Hemoglobin (Hb) isolated from the backswimmer Buenoa margaritacea has been analyzed spectroscopically. The met form at pH less than 6 shows a 30nm red shift in the Qv and Qo bands and a 5nm red shift in the Soret band compared to mammalian Hb, while only minor differences are seen in the spectra of the CO and O2 adduc...

journal_title：Biochemical and biophysical research communications

authors： Osmulski PA,Vossbrinck CR,Sampath V,Caughey WS,Debrunner PG

更新日期：1992-09-16 00:00:00

abstract：:The multidrug resistance proteins P-glycoprotein (Pgp) and MRP1 are drug-efflux pumps. In this study, we compared the nucleotide triphosphatase activities of the isolated N-terminal nucleotide binding domains (NBD1) of Pgp and MRP1, and explored the potential role of the phosphorylation target domain of Pgp on the reg...

journal_title：Biochemical and biophysical research communications

authors： Wilkes DM,Wang C,Aristimuño PC,Castro AF,Altenberg GA

更新日期：2002-08-16 00:00:00

abstract：:Increasing the number of transcription factor binding sites within a construct can enhance expression. In an attempt to create a synthetic locus control region for mammary expression, we have generated beta-lactoglobulin-reporter constructs with multiple copies of the cluster of transcription sites normally located wi...

journal_title：Biochemical and biophysical research communications

authors： James RM,Neil C,Webster J,Roos S,Clark AJ,Whitelaw CB

更新日期：2000-05-27 00:00:00

abstract：:Nitric oxide synthase (EC 1.14.23) substrate analog inhibitors NG-monomethyl-L-Arg, NG-nitro-L-Arg, NG-nitro-L-Arg methyl ester, and aminoguanidine were examined as potential inhibitors of rat liver arginase (EC 3.5.3.1). NG-nitro-L-Arg was found to inhibit arginase catalyzed conversion of L-Arg to L-Orn at pH 7.5 wit...

journal_title：Biochemical and biophysical research communications

authors： Robertson CA,Green BG,Niedzwiecki L,Harrison RK,Grant SK

更新日期：1993-12-15 00:00:00

abstract：:Rat neuromedin U was isolated from the small intestine using mainly immunoaffinity chromatography and radioimmunoassay for pig neuromedin U-8. The amino acid sequence of rat neuromedin U was determined by microsequence analysis to be Tyr-Lys-Val-Asn-Glu-Tyr-Gln-Gly-Pro-Val-Ala-Pro-Ser-Gly-Gly- Phe-Phe-Leu-Phe-Arg-Pro-...

journal_title：Biochemical and biophysical research communications

authors： Minamino N,Kangawa K,Honzawa M,Matsuo H

更新日期：1988-10-14 00:00:00

abstract：:In rat mesenteric vessels changes in external pH (pHo) alter tension. Changes in intracellular pH (pHi) and calcium ([Ca2+]i) have both been suggested to underlie the tension changes. As no simultaneous measurements of pHi and [Ca2+]i had been made, however, the relative importance and temporal relationship between pH...

journal_title：Biochemical and biophysical research communications

authors： Austin C,Dilly K,Eisner D,Wray S

更新日期：1996-05-15 00:00:00

abstract：:Licochalcone (LA) is a novel estrogenic flavonoid isolated from PC-SPES composition herb licorice root that was reported to show significant antitumor activity in various malignant human cell lines. To better understand its anti-CaP activities, we have investigated LA-elicited growth control and induction of apoptosis...

journal_title：Biochemical and biophysical research communications

authors： Fu Y,Hsieh TC,Guo J,Kunicki J,Lee MY,Darzynkiewicz Z,Wu JM

更新日期：2004-09-10 00:00:00

abstract：:Ribose methylation of eukaryotic rRNA is directed by box C/D small nucleolar RNAs (snoRNAs), which pinpoint the nucleotide to be methylated in specific position within the rRNA sequence. Here, we report the identification of a novel double-guide C/D box snoRNA termed snR88 that directs methylation of two previously un...

journal_title：Biochemical and biophysical research communications

authors： Bi YZ,Qu LH,Zhou H

更新日期：2007-03-02 00:00:00

abstract：:Chromatography of a rat liver extract on DEAE-cellulose resulted in the near total loss of 3-hydroxyacyl-CoA epimerase activity. The activity was regained either when fractions were recombined or when purified crotonase was added to the early column fractions. A new enoyl-CoA hydratase present in these early fractions...

journal_title：Biochemical and biophysical research communications

authors： Smeland TE,Li JX,Chu CH,Cuebas D,Schulz H

更新日期：1989-05-15 00:00:00

abstract：:Lysophosphatidylcholine (lyso-PC), a biologically active phospholipid, appears to modulate various endothelial cell functions through tyrosine kinase-dependent signaling pathways. In cultured bovine aortic endothelial cells (BAEC), we have found that a 130 kDa protein (p130) was rapidly tyrosine phosphorylated within ...

journal_title：Biochemical and biophysical research communications

authors： Ochi H,Kume N,Nishi E,Moriwaki H,Masuda M,Fujiwara K,Kita T

更新日期：1998-02-24 00:00:00

abstract：:MS-209 is a novel quinoline derivative reversing P-glycoprotein-mediated multidrug resistance (MDR). We investigated the interaction between MS-209 and multidrug resistance protein (MRP) in MRP-overexpressing human gastric cancer cells. We measured [3H]leukotriene C4 uptake into the membrane vesicles of the cells and ...

journal_title：Biochemical and biophysical research communications

authors： Nakamura T,Oka M,Aizawa K,Soda H,Fukuda M,Terashi K,Ikeda K,Mizuta Y,Noguchi Y,Kimura Y,Tsuruo T,Kohno S

更新日期：1999-02-24 00:00:00

abstract：:With the global pandemic of hepatitis B and C infections, the incidence of Hepatocellular carcinoma (HCC) is rapidly increasing world wide. We identified glypican-3 (GPC3), a novel oncofetal gene over-expressed specifically in human HCC, as based on data of cDNA microarrays. As GPC3 is a GPI-anchored membrane protein ...

journal_title：Biochemical and biophysical research communications

authors： Nakatsura T,Yoshitake Y,Senju S,Monji M,Komori H,Motomura Y,Hosaka S,Beppu T,Ishiko T,Kamohara H,Ashihara H,Katagiri T,Furukawa Y,Fujiyama S,Ogawa M,Nakamura Y,Nishimura Y

更新日期：2003-06-20 00:00:00

abstract：:p73 is a member of the p53 family of transcription factors which plays an essential role in tumor suppression. p73 is associated with the sensitivity of cancer cells to chemotherapy and the prognosis of many cancers. In this study, we showed the ubiquitination-dependent degradation of p73 by the mitochondrial E3 ubiqu...

journal_title：Biochemical and biophysical research communications

authors： Min B,Ryu J,Chi SW,Yi GS

更新日期：2015-11-13 00:00:00