Identification of covalently attached fatty acids in the hydrophobic membrane-binding domain of human erythrocyte acetylcholinesterase.

abstract：:Traumatic spinal cord injury (SCI) is a major cause of death and lifelong disability in the world. However, the pathological process of SCI has not been fully understood. F-box/WD repeat-containing protein 5 (FBXW5), a subunit of the SCF-type E3 ubiquitin ligase complex, plays an essential role in regulating various p...

journal_title：Biochemical and biophysical research communications

authors： Zhao P,Chao W,Li W

更新日期：2019-06-25 00:00:00

abstract：:The DNA-binding activity of a 42-kDa phosphoprotein from salivary gland cells and cultured epithelial cells of Chironomus tentans have been analyzed by the Southwestern technique. Both the salivary gland and the epithelial cell 42-kDa polypeptides were found to be single-stranded DNA-binding proteins. They bind to sin...

journal_title：Biochemical and biophysical research communications

authors： Stigare J,Egyhazi E

更新日期：1991-05-15 00:00:00

abstract：:The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health crisis. It is particularly urgent to develop clinically effective therapies to contain the pandemic. The main protease (Mpro) and the RNA-dependent RNA poly...

journal_title：Biochemical and biophysical research communications

authors： Jin Z,Wang H,Duan Y,Yang H

更新日期：2020-11-21 00:00:00

abstract：:Linkage-specific polyubiquitination regulates many cellular processes. The N-terminal fragment of Rabex-5 (Rabex-5(9-73)) contains tandem ubiquitin binding domains: A20_ZF and MIU. The A20_ZF-MIU of Rabex-5 is known to bind monoubiquitin but molecular details of polyubiquitin binding affinity and linkage selectivity b...

journal_title：Biochemical and biophysical research communications

authors： Shin D,Lee SY,Han S,Ren S,Kim S,Aikawa Y,Lee S

更新日期：2012-07-13 00:00:00

abstract：:Monoclonal antibodies are essential to the success of molecularly targeted therapies. Recently, numerous therapeutic antibodies have been developed for various diseases, including cancer and autoimmune diseases. Experimental systems to effectively evaluate these candidate antibodies are urgently needed. One of the mec...

journal_title：Biochemical and biophysical research communications

authors： Shiokawa M,Takahashi T,Murakami A,Kita S,Ito M,Sugamura K,Ishii N

更新日期：2010-09-03 00:00:00

abstract：:Rearrangement of the p53 gene is frequent in virus transformed cell lines and in chronic myelogenous leukemia. It is a rare event in solid tumours and has been reported only in osteosarcomas. In this study we have examined rearrangement of the p53 gene in human breast tumours. We found rearrangement in 35% of the pati...

journal_title：Biochemical and biophysical research communications

authors： Nayak BK,Patnaik S,Das BR

更新日期：1998-04-17 00:00:00

abstract：:Tetrahymena p85 is localized to the presumptive division plane before division furrow formation; its molecular weight in SDS-polyacrylamide gel electrophoresis differs in wild-type and temperature-sensitive cell-division-arrest mutant cdaA1 cells. At the restrictive temperature, p85 localization and division furrow fo...

journal_title：Biochemical and biophysical research communications

authors： Gonda K,Nishibori K,Ohba H,Watanabe A,Numata O

更新日期：1999-10-14 00:00:00

abstract：:The BLM-Ni(III) complex preferentially cleaves guanine residues at D loop and anticodon loop of yeast tRNA(phe) by aniline treatment, whereas the BLM-Co(III) complex degrades certain 5'-AN sites of the minor groove region after irradiation of UV light. These cleavage features are clearly different from that of the BLM...

journal_title：Biochemical and biophysical research communications

authors： Guan LL,Totsuka R,Kuwahara J,Otsuka M,Sugiura Y

更新日期：1993-03-31 00:00:00

abstract：:The addition of low concentrations of phorbol 12-myristate 13-acetate to rabbit neutrophils induces cell aggregation, degranulation, increased oxygen consumption and an increase in the amount of actin associated with the cytoskeleton without a rise in the level of intracellular free calcium as measured using the fluor...

journal_title：Biochemical and biophysical research communications

authors： Sha'afi RI,White JR,Molski TF,Shefcyk J,Volpi M,Naccache PH,Feinstein MB

更新日期：1983-07-29 00:00:00

abstract：:The aim of this work was to characterize folates modified by ONOO(-) and HOCl and to evaluate the binding capacity of folates modified by ONOO(-) to folate receptor alpha and beta. For the modification of folate by ONOO(-), folic acid was reacted with the combination of PMA activated PMN and PAPA NONOate or chemically...

journal_title：Biochemical and biophysical research communications

authors： Nakamura M,Nagayoshi R,Ijiri K,Nakashima-Matsushita N,Takeuchi T,Matsuyama T

更新日期：2002-10-11 00:00:00

abstract：:Therapeutic effects of combination of angiogenic growth factors for the treatment of ischemia after myocardial infarction are largely unknown. Plasmids expressing basic fibroblast growth factor (bFGF), platelet-derived growth factor (PDGF-BB) or their combination with a 1:1 mass ratio were injected into hearts with 7-...

journal_title：Biochemical and biophysical research communications

authors： Hao X,Månsson-Broberg A,Gustafsson T,Grinnemo KH,Blomberg P,Siddiqui AJ,Wärdell E,Sylvén C

更新日期：2004-03-19 00:00:00

abstract：:We previously demonstrated that the translocation of phospholipids between the mitochondrion and the endoplasmic reticulum occurs via highly specialized membrane microdomains of both organelles that are in situ closely associated. As understanding of the interactions between both organelles requires characterization o...

journal_title：Biochemical and biophysical research communications

authors： Gasnier F,Ardail D,Febvay G,Simonot C,Lerme F,Guillaud J,Louisot P,Gateau-Roesch O

更新日期：1993-09-30 00:00:00

abstract：:Growth and differentiation factors (GDF)-5, -6, and -7 are members of the bone morphogenetic protein (BMP) family. Previous studies suggest their importance in bone development and in tendon/ligament morphogenesis. The cells of the dental attachment apparatus, cementum, periodontal ligament, and alveolar bone proper a...

journal_title：Biochemical and biophysical research communications

authors： Morotome Y,Goseki-Sone M,Ishikawa I,Oida S

更新日期：1998-03-06 00:00:00

abstract：:By the determination of pyruvate dehydrogenase activity in tissue homogenates only limited information is gained on the actual metabolic flux. We therefore determined pyruvate decarboxylation in isolated rat hindlimbs non recirculating perfused with physiological (1-14C)pyruvate levels. On the basis of perfusate pyruv...

journal_title：Biochemical and biophysical research communications

authors： Schadewaldt P,Münch U,Prengel M,Staib W

更新日期：1983-10-31 00:00:00

abstract：:The ability of parathyroid hormone (PTH) to enhance bone formation has recently been exploited in the treatment of osteoporosis. Several studies have suggested that the activation of bone marrow stromal cells could be preceded to show the anabolic effect of PTH on bone formation, but little is known of PTH-regulated p...

journal_title：Biochemical and biophysical research communications

authors： Kim SH,Jun S,Jang HS,Lim SK

更新日期：2005-05-06 00:00:00

abstract：:Blebbistatin is a novel 1-phenyl-2-pyrrolidinone derivative capable of inhibiting non-muscle myosin II activity with a high degree of specificity. We examined the effects of blebbistatin on pancreatic adenocarcinoma cellular migration, invasion, adhesion, and spreading. Blebbistatin dose-dependently inhibited cellular...

journal_title：Biochemical and biophysical research communications

authors： Duxbury MS,Ashley SW,Whang EE

更新日期：2004-01-23 00:00:00

abstract：:Ultraviolet, fluorescence and CD spectral analysis suggested unusual structural features of Rhodotorula gracilis ATCC 90950 DNA. R. gracilis DNA exhibited 13% hyperchromicity at 260 nm as against 26% shown by calf thymus DNA. The biphasic melting curve, one phase between 88-92 degrees C and the other between 92-97 deg...

journal_title：Biochemical and biophysical research communications

authors： Vishnuvardhan D,Divakar S,Joseph R

更新日期：1995-06-26 00:00:00

abstract：:Heme is central to oxygen sensing and utilization in all living organisms. It directly regulates numerous molecular and cellular processes for systems that sense or use oxygen. In mammals, heme plays an indispensable role in erythroid cell differentiation. To investigate heme regulatory functions, we identified, by di...

journal_title：Biochemical and biophysical research communications

authors： Zhu Y,Hon T,Zhang L

更新日期：1999-04-29 00:00:00

abstract：:Recently, a novel oxysterol, 5-cholesten-3beta, 25-diol 3-sulfate (25HC3S) was identified in primary rat hepatocytes following overexpression of the cholesterol transport protein, StarD1. This oxysterol was also detected in human liver nuclei. In the present study, 25HC3S was chemically synthesized. Addition of 25HC3S...

journal_title：Biochemical and biophysical research communications

authors： Ren S,Li X,Rodriguez-Agudo D,Gil G,Hylemon P,Pandak WM

更新日期：2007-09-07 00:00:00

abstract：:Intestinal challenge with cholera toxin induces the synthesis of a hormone-like protein which counteracts intestinal hypersecretion. This study shows that the protein also inhibits GABA transport across the plasma membrane of Deiters' cells in rabbits. The inhibitory action of the protein was dose dependent, and 10(3)...

journal_title：Biochemical and biophysical research communications

authors： Lange S,Lönnroth I,Palm A,Hydén H

更新日期：1985-08-15 00:00:00

abstract：:Oxidative damage to DNA has been reported to occur in a wide variety of disease states. The most widely used "marker" for oxidative DNA damage is 8-hydroxyguanine. However, the use of only one marker has limitations. Exposure of calf thymus DNA to an .OH-generating system (CuCl(2), ascorbate, H(2)O(2)) or to hypochlor...

journal_title：Biochemical and biophysical research communications

authors： Whiteman M,Hong HS,Jenner A,Halliwell B

更新日期：2002-08-30 00:00:00

abstract：:Protein phosphatase 2C (PP2C) is one of the four major protein serine/threonine phosphatases of eukaryotes and is implicated in the regulation of various cellular functions. With the goal of elucidating the mechanism responsible for regulating PP2C functions, we investigated the significance of phosphorylation of fiss...

journal_title：Biochemical and biophysical research communications

authors： Kobayashi T,Sadaie M,Ohnishi M,Wang H,Ikeda S,Hanada M,Yanagawa Y,Nakajima T,Tamura S

更新日期：1998-10-09 00:00:00

abstract：:Stimulation of neutrophils with LTB(4) or PAF results in the production of a rapidly oscillating actin polymerization/depolymerization response. Treatment of neutrophils with inhibitors of PKC prior to stimulation with ligand resulted in a masking of the F-actin oscillations. Because myosin has been shown to be a subs...

journal_title：Biochemical and biophysical research communications

authors： Rengan R,Omann GM

更新日期：1999-08-27 00:00:00

abstract：:SIRT2 is a member of the sirtuin family of NAD(+)-dependent protein deacetylases. It is involved in metabolic homeostasis and has been linked to the progression of age-related diseases. Casitas B-lineage lymphoma (Cbl) proteins regulate signal transduction through many pathways and, consequently, regulate cell functio...

journal_title：Biochemical and biophysical research communications

authors： Choi YH,Kim H,Han Y,Jin YH,Lee KY

更新日期：2014-10-24 00:00:00

abstract：:2-((2-Pyridylmethyl)sulfinyl)benzimidazoles, selective inhibitors of the H+/K+-ATPase in the parietal cells of the stomach, have been investigated concerning their chemical behaviour in acidic medium. Protonation of the sulfoxide and subsequent elimination of water forms a sulfenium ion or a chemical equivalent thereo...

journal_title：Biochemical and biophysical research communications

authors： Rackur G,Bickel M,Fehlhaber HW,Herling A,Hitzel V,Lang HJ,Rösner M,Weyer R

更新日期：1985-04-16 00:00:00

abstract：:A number of cyclohexenyl chalcone Diels-Alder natural products possess promising biological properties including strong cytotoxicity in various human cancer cells. Herein, we show that natural products in this class including panduratin A and nicolaioidesin C inhibit cysteine cathepsins as indicated by protease profil...

journal_title：Biochemical and biophysical research communications

authors： Deb Majumdar I,Devanabanda A,Fox B,Schwartzman J,Cong H,Porco JA Jr,Weber HC

更新日期：2011-12-16 00:00:00

abstract：:We investigated immunohistochemically the localization of p33, an endogenous substrate protein for an arginine-specific ADP-ribosyltransferase in chicken liver. Polymorphonuclear-pseudo-eosinophilic granulocytes (heterophils) in interlobular connective tissues of the liver were exclusively and strongly stained with th...

journal_title：Biochemical and biophysical research communications

authors： Osago H,Mishima K,Tsuchiya M,Tanigawa Y,Umeno T,Shimoyama M

更新日期：1991-10-15 00:00:00

abstract：:In investigations on self-splicing in the group I intron of the pre-mRNA from the nrdB gene of bacteriophage T4 it was found that 2'-amino-2'-deoxyguanosine can replace guanosine as cofactor. This is the first guanosine-analogue with a modification in the 2'-position and substantial activity in a group I self-splicing...

journal_title：Biochemical and biophysical research communications

authors： Strömberg R,Hahne S,Sjögren AS,Sjöberg BM

更新日期：1992-03-16 00:00:00

abstract：:Monoamine oxidase B (MAO-B) functions in the deamination of monoamines, including dopamine and norepinephrine. The search for MAO-B inhibitors increased following the discovery that the enzyme may be responsible for generating neurotoxins from various endogenous or exogenous compounds. Computational screening methods ...

journal_title：Biochemical and biophysical research communications

authors： Harkcom WT,Bevan DR

更新日期：2007-08-24 00:00:00

abstract：:Infection of influenza virus could induce acute lung inflammatory injury (ALII) that was at least partially caused by excessive innate immune responses. To study whether down-regulating Toll-like receptor (TLR)-mediated innate immune response could lessen influenza virus-induced ALII, a microsatellite DNA mimicking ol...

journal_title：Biochemical and biophysical research communications

authors： Fang M,Wan M,Guo S,Sun R,Yang M,Zhao T,Yan Y,Zhang Y,Huang W,Wu X,Yu Y,Wang L,Hua S

更新日期：2011-11-18 00:00:00