Abstract:
:In investigations on self-splicing in the group I intron of the pre-mRNA from the nrdB gene of bacteriophage T4 it was found that 2'-amino-2'-deoxyguanosine can replace guanosine as cofactor. This is the first guanosine-analogue with a modification in the 2'-position and substantial activity in a group I self-splicing reaction. The results suggest that the 2'-amino and 2'-hydroxy groups of the cosubstrates have some properties in common, which are important for binding as well as for catalysis.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Strömberg R,Hahne S,Sjögren AS,Sjöberg BMdoi
10.1016/0006-291x(92)90560-8subject
Has Abstractpub_date
1992-03-16 00:00:00pages
842-8issue
2eissn
0006-291Xissn
1090-2104pii
0006-291X(92)90560-8journal_volume
183pub_type
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journal_title:Biochemical and biophysical research communications
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更新日期:2014-01-17 00:00:00