Further evidence for both functional and structural microcompartmentation within the membranes of two associated organelles, mitochondrion and endoplasmic reticulum.

abstract：:Post-translational modification (PTM) of proteins plays a crucial role in health and disease by affecting numerous aspects of protein structure, function, stability and subcellular localization. Protein S-nitrosylation is one type of PTM that involves the covalent modification of cysteine sulfhydryl groups with nitric...

journal_title：Biochemical and biophysical research communications

authors： Khatib S,Artoul F,Gershko M,Markman G,Vaya J

更新日期：2014-02-14 00:00:00

abstract：:ELOVL3 is involved in elongating saturated and monounsaturated fatty acids, and is a critical enzyme for lipid accumulation in brown adipocytes during the early phase of tissue recruitment. In addition, ELOVL3 is related to increased fatty acid oxidation in brown adipocytes. However, the potential functions of ELOVL3 ...

journal_title：Biochemical and biophysical research communications

authors： Liu D,Xu JH,Tong HL,Li SF,Yan YQ

更新日期：2017-12-02 00:00:00

abstract：:Ammonia-forming cytochrome c nitrite reductase from Sulfurospirillum deleyianum contains four covalently bound heme c groups/55 kDa subunit as determined by atomic absorption spectroscopy and the pyridine Fe(II)-hemochrome technique. Nitrite reductase was isolated from the membrane fraction as a monomer (M(r) 55 +/- 2...

journal_title：Biochemical and biophysical research communications

authors： Schumacher W,Hole U,Kroneck PM

更新日期：1994-11-30 00:00:00

abstract：:A high concentration of immunoreactive neuropeptide Y was observed in rat platelets using a specific and sensitive radioimmunoassay for neuropeptide Y. Three kinds of high performance liquid chromatography combined with radioimmunoassay for neuropeptide Y showed that immunoreactive neuropeptide Y in rat platelets is i...

journal_title：Biochemical and biophysical research communications

authors： Ogawa T,Kitamura K,Kawamoto M,Eto T,Tanaka K

更新日期：1989-12-29 00:00:00

abstract：:beta-Amyloid peptide (beta A) is a major fibrillar component of neuritic plaques in Alzheimer's disease (AD) brains and is related to the pathogenesis of the disease. In this study, using electron microscopy, we describe herein the results concerning the efficacy of compounds that can dissolve preformed beta A fibrils...

journal_title：Biochemical and biophysical research communications

authors： Nguyen KV,Gendrault JL,Wolff CM

更新日期：2002-03-08 00:00:00

abstract：:Studies suggest that the anticancer drugs VP16-213 and VM26 produce cytotoxicity by inducing protein-associated DNA breakage in vivo through interaction with a yet unknown nuclear component. The effects of these drugs and their congeners on topoisomerase activities was investigated. VP16-213, VM26, and congeners activ...

journal_title：Biochemical and biophysical research communications

authors： Minocha A,Long BH

更新日期：1984-07-18 00:00:00

abstract：:Human follitropin receptor (hFSHR) cDNA was inserted into the genome of Autographa californica nuclear polyhedrosis virus under the control of the polyhedrin promoter. Spodoptera frugiperda (Sf9) insect cells expressed the hFSHR at the membrane level, 2-3 days after infection. Ligand binding analysis demonstrated satu...

journal_title：Biochemical and biophysical research communications

authors： Christophe S,Robert P,Maugain S,Bellet D,Koman A,Bidart JM

更新日期：1993-10-15 00:00:00

abstract：:Suppressor of cytokine signaling (SOCS) 1 was initially identified as an intracellular negative feedback regulator of the JAK-STAT signal pathway. Recently, it has been suggested that SOCS1 affects signals of growth factors and hormones. One of them, SOCS1, is also known to be involved in auto-regulation of IRS-1-medi...

journal_title：Biochemical and biophysical research communications

authors： Inaba M,Saito H,Fujimoto M,Sumitani S,Ohkawara T,Tanaka T,Kouhara H,Kasayama S,Kawase I,Kishimoto T,Naka T

更新日期：2005-03-25 00:00:00

abstract：:High serum selenium levels have been associated epidemiologically with increased incidence of type 2 diabetes. The major fraction of total selenium in serum is represented by liver-derived selenoprotein P (SeP). This study was undertaken to test for a hypothesized effect of hyperglycemia and the antihyperglycemic drug...

journal_title：Biochemical and biophysical research communications

authors： Speckmann B,Sies H,Steinbrenner H

更新日期：2009-09-11 00:00:00

abstract：:Angiogenesis is a core hallmark of advanced cancers, especially in lung adenocarcinoma (LUAD). However, the underlying functions and mechanisms of lncRNAs in tumor angiogenesis remain largely unknown. Here we found that linc00665 depletion could markedly depressed proliferation and capillary tube formation of HUVECs i...

journal_title：Biochemical and biophysical research communications

authors： Cong Z,Diao Y,Li X,Jiang Z,Xu Y,Zhou H,Qiang Y,Wu H,Shen Y

更新日期：2020-06-25 00:00:00

abstract：:The K-sam gene was first identified as an amplified gene in the poorly differentiated types, especially in the scirrhous type, of gastric cancers. We have recently found and reported that the carboxyl-terminal exons of K-sam are frequently deleted in the scirrhous type of gastric cancer. The deletion generates prefere...

journal_title：Biochemical and biophysical research communications

authors： Ueda T,Sasaki H,Aoyagi K,Narikiyo M,Tsubosa Y,Kuwahara Y,Sakamoto H,Mafune K,Yoshida T,Makuuchi M,Terada M

更新日期：1999-11-30 00:00:00

abstract：:Parathymosin has been purified from calf liver and its primary sequence established, except for a segment containing approximately 11 amino acid residues in the central part of the polypeptide chain. Bovine parathymosin contains approximately 101 amino acid residues and shows 90% identity with rat parathymosin, with s...

journal_title：Biochemical and biophysical research communications

authors： Panneerselvam C,Clinton M,Wellner D,Horecker BL

更新日期：1988-09-15 00:00:00

abstract：:We previously found a new endogenous factor in rat liver cytosol, named ATP-stimulated glucocorticoid-receptor translocation promoter (ASTP), that increased the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP. We have cloned and sequenced a cDNA (2989 bp) encoding the ASTP protein. An ope...

journal_title：Biochemical and biophysical research communications

authors： Okamoto K,Hirano H,Isohashi F

更新日期：1993-06-30 00:00:00

abstract：:Transport of alpha-ketoisocaproate (KIC), a ketoacid originating from leucine and proposed to be involved in the buffering of glutamate in neurones, was studied in neuroblastoma NB-2a cells. The accumulated KIC was mostly transaminated to leucine, while free keto-acid was detectable either only after prolonged times o...

journal_title：Biochemical and biophysical research communications

authors： Bachowska-Mac M,Nehlig A,Nałecz MJ,Nałecz KA

更新日期：1997-08-08 00:00:00

abstract：:Peroxisomes catalyze a number of essential metabolic functions especially related to lipid metabolism. There is increasing evidence suggesting that peroxisomes are also involved in the synthesis of isoprenoids via the mevalonate pathway at least in rat liver. In order to obtain independent evidence for a role of perox...

journal_title：Biochemical and biophysical research communications

authors： Wanders RJ,Romeijn GJ

更新日期：1998-06-29 00:00:00

abstract：:To elucidate the physiological importance of neuronal (N)-type calcium channels in sympathetic controls, we analyzed N-type channel-deficient (NKO) mice. Immunoprecipitation analysis revealed increased interaction between beta3 (a major accessory subunit of N-type channels) and R-type channel-forming CaV2.3 in NKO mic...

journal_title：Biochemical and biophysical research communications

authors： Murakami M,Ohba T,Wu TW,Fujisawa S,Suzuki T,Takahashi Y,Takahashi E,Watanabe H,Miyoshi I,Ono K,Sasano H,Ito H,Iijima T

更新日期：2007-03-23 00:00:00

abstract：:Two isoforms of the src-family tyrosine kinase p59fyn have been shown to arise through alternative splicing of exon 7 of the fyn gene. These isoforms have been designated fynT, expressed in hematopoietic cells, and fynB, expressed in the brain. Here, we describe a novel isoform, fynDelta7, in which exon 7 is absent. F...

journal_title：Biochemical and biophysical research communications

authors： Goldsmith JF,Hall CG,Atkinson TP

更新日期：2002-11-08 00:00:00

abstract：:Emp, originally detected in erythroblastic islands, is expressed in numerous cell types and tissues suggesting a functionality not limited to hematopoiesis. To study the function of Emp in non-hematopoietic cells, an epitope-tagged recombinant human Emp was expressed in HEK cells. Preliminary studies revealed that Emp...

journal_title：Biochemical and biophysical research communications

authors： Bala S,Kumar A,Soni S,Sinha S,Hanspal M

更新日期：2006-04-21 00:00:00

abstract：:Thyroglobulin of very low iodine content has been prepared from a single non-toxic human goitre. The initial iodine content of the protein (0.038%) has been increased to levels of 0.16% and 0.85% by in vitro treatment with thyroid peroxidase and the resulting proteins studied with respect to their intrinsic fluorescen...

journal_title：Biochemical and biophysical research communications

authors： Zabel KM,Rawitch AB

更新日期：1984-05-31 00:00:00

abstract：:Hyperphosphorylation of extracellular signal-regulated protein kinases-1/2 (ERK1/2) is known to promote cancer cell proliferation. We therefore investigated the constitutive phosphorylation levels of ERK1/2 and the expression of its downstream targets c-Fos, c-Jun, and cyclooxygenase-2 (COX-2) in biopsied human gastri...

journal_title：Biochemical and biophysical research communications

authors： Wu WK,Sung JJ,Yu L,Li ZJ,Chu KM,Cho CH

更新日期：2008-08-22 00:00:00

abstract：:In a span of approximately 13 kb, two genomic fragments showing an obvious overlap encoded the 1,192 base pair (bp) cDNA sequence for human H-protein. Because of the close similarity in the genomic organization comprised of five exons to that for the chicken H-protein gene, this region was assigned to the true H-prote...

journal_title：Biochemical and biophysical research communications

authors： Koyata H,Hiraga K

更新日期：1991-08-15 00:00:00

abstract：:Heart fatty acid binding protein (H-FABP) is a 15kDa protein that mediates the passage of fatty acids from the plasma membrane to sites of lipid synthesis. We report here, for the first time, that H-FABP is a potent inducer of cardiac myocyte hypertrophy, stimulating an increase in cell surface area, protein synthesis...

journal_title：Biochemical and biophysical research communications

authors： Burton PB,Hogben CE,Joannou CL,Clark AG,Hsuan JJ,Totty NF,Sorensen C,Evans RW,Tynan MJ

更新日期：1994-12-30 00:00:00

abstract：:We located a novel binding site for grayanotoxin on the cytoplasmic linkers of voltage-dependent cardiac (rH1) or skeletal-muscle (mu 1) Na(+) channel isoforms (segments S4-S5 in domains D1 and D4), using the alanine scanning substitution method. GTX-modification of Na(+) channels, transiently expressed in HEK 293 cel...

journal_title：Biochemical and biophysical research communications

authors： Maejima H,Kinoshita E,Yuki T,Yakehiro M,Seyama I,Yamaoka K

更新日期：2002-07-12 00:00:00

abstract：:NADPH oxidases (NOX) - derived reactive oxygen species (ROS) contribute to oxidative injury in hypoxia-induced pulmonary arterial hypertension. This study aims to evaluate the status of NOX in endothelial progenitor cells (EPCs) under hypoxic condition and to determine whether NOX inhibitors could attenuate hypoxia-in...

journal_title：Biochemical and biophysical research communications

authors： Liu B,Ren KD,Peng JJ,Li T,Luo XJ,Fan C,Yang JF,Peng J

更新日期：2017-01-22 00:00:00

abstract：:We have investigated the effect of PARP gene inactivation on the expression of wild-type (wt) p53 protein. Using immortalized fibroblasts from control and PARP knock-out mice we have found by immunoblotting with the PAb421 antibody a profound decrease of the p53 expression to a barely detectable level in PARP knock-ou...

journal_title：Biochemical and biophysical research communications

authors： Schmid G,Wang ZQ,Wesierska-Gadek J

更新日期：1999-02-16 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) had been proved to be pivotal regulators in carcinogenesis. On the basis of competitive endogenous RNAs (ceRNAs) system, lncRNAs significantly expanded their regulating networks. In our research, we aimed to figure out the exact role of lncRNA HNF1A-AS1 in the pathogenesis of hepatocellu...

journal_title：Biochemical and biophysical research communications

authors： Liu Z,Wei X,Zhang A,Li C,Bai J,Dong J

更新日期：2016-05-13 00:00:00

abstract：:Six forms of cytochrome P-450 in the mitochondria of larvae from Musca domestica were isolated by solubilization with CHAPS followed by ammonium sulfate fractionation and HPLC on an anion-exchange column. Forms 1, 2, 3, 5, and 6 catalyzed the formation of 20-hydroxy-ecdysone from ecdysone in the presence of NADPH and ...

journal_title：Biochemical and biophysical research communications

authors： Srivatsan J,Weirich M,Agosin M

更新日期：1990-02-14 00:00:00

abstract：:The ATP-sensitive potassium channel of insulin-secreting pancreatic beta-cells is a complex of Kir6.2, a member of the inwardly rectifying potassium channel superfamily, and the sulfonylurea receptor. We have isolated cDNA clones encoding rat Kir6.2. Co-expression of rat Kir6.2 and sulfonylurea receptor in human embry...

journal_title：Biochemical and biophysical research communications

authors： Tokuyama Y,Fan Z,Furuta H,Makielski JC,Polonsky KS,Bell GI,Yano H

更新日期：1996-03-27 00:00:00

abstract：:Hairpin antisense oligodeoxyribonucleotides containing 2'-methoxynucleosides were more active in the micromolar concentration range than linear and DNA hairpin phosphorothioate oligonucleotides with the same sequence. Furthermore, the abilities of hairpin antisense and random hairpin phosphorothioate oligonucleotides ...

journal_title：Biochemical and biophysical research communications

authors： Kuwasaki T,Hosono K,Takai K,Ushijima K,Nakashima H,Saito T,Yamamoto N,Takaku H

更新日期：1996-11-12 00:00:00

abstract：:Inflammatory signals associated with cardiac diseases trigger trans-differentiation of cardiac fibroblasts to cardiac myofibroblasts. Cardiac myofibroblasts are the main cell type involved in the development of cardiac fibrosis, a diffuse and disproportionate accumulation of collagen in the myocardium. Although the ro...

journal_title：Biochemical and biophysical research communications

authors： Villa M,Cerda-Opazo P,Jimenez-Gallegos D,Garrido-Moreno V,Chiong M,Quest AF,Toledo J,Garcia L

更新日期：2020-04-09 00:00:00