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The metal-mediated formation of hydroxyl radical by aqueous extracts of cigarette tar.

Abstract：

:Aqueous extracts of cigarette tar produce hydroxyl radicals that are spin trapped by 5,5-dimethyl-1-pyrroline-N-oxide. The addition of catalase almost completely inhibits and superoxide dismutase partially inhibits spin adduct formation. The addition of ethylenediamine tetraacetic acid greatly increases the amount of hydroxyl radical adduct observed; in contrast, diethylenetriamine pentaacetic acid causes complete inhibition of spin adduct formation. We suggest that the hydroxyl radical arises from the metal-mediated decomposition of hydrogen peroxide, and that hydrogen peroxide is formed from the reduction of dioxygen by the semiquinones present in the cigarette tar.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Cosgrove JP,Borish ET,Church DF,Pryor WA

doi

10.1016/0006-291x(85)91034-4

subject

Has Abstract

pub_date

1985-10-15 00:00:00

pages

390-6

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(85)91034-4

journal_volume

132

pub_type

杂志文章

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