High D-glucose stimulates the cell cycle from the G1 to the S and M phases, but has no competent effect on the G0 phase, in vascular smooth muscle cells.

abstract：:Vasodilator-stimulated phosphoprotein (VASP) is an actin regulatory protein that functions in adhesion and migration. In epithelial cells, VASP participates in cell-cell adhesion. At the molecular level, VASP drives actin bundling and polymerization. VASP activity is primarily regulated by phosphorylation. Three physi...

journal_title：Biochemical and biophysical research communications

authors： Thomson DM,Ascione MP,Grange J,Nelson C,Hansen MD

更新日期：2011-10-14 00:00:00

abstract：:The human pancreas carcinoma cell line T3M-4 contains activated c-Kirsten (K)-ras oncogene detectable by the DNA-mediated gene transfer technique using NIH/3T3 cells. DNA fragments containing coding lesions have been cloned, and nucleotide sequence analysis suggests that the T3M-4 oncogene has been activated by a sing...

journal_title：Biochemical and biophysical research communications

authors： Hirai H,Okabe T,Anraku Y,Fujisawa M,Urabe A,Takaku F

更新日期：1985-02-28 00:00:00

abstract：:Low-molecular-weight metabolites in human milk are gaining increasing interest in studies of infant nutrition. In the present study, the milk metabolome from a single mother was explored at different stages of lactation. Metabolites were extracted from sample aliquots using either methanol/water (MeOH/H2O) extraction ...

journal_title：Biochemical and biophysical research communications

authors： Wu J,Domellöf M,Zivkovic AM,Larsson G,Öhman A,Nording ML

更新日期：2016-01-15 00:00:00

abstract：:Adherens junction-associated protein-1 (AJAP1), also called SHREW1, was first discovered as a novel component of adherens junctions in 2004. In later studies, AJAP1 was found to suppress invasion and predict recurrence of some tumors. Apart from its function as a putative tumor suppressor, AJAP1 is still poorly unders...

journal_title：Biochemical and biophysical research communications

authors： Zhang M,Zhou X,Jiang W,Li M,Zhou R,Zhou S

更新日期：2020-04-16 00:00:00

abstract：:Antithrombin III (ATIII) performs a critical anticoagulant function by precluding the activation of blood clotting proteinases, aided by its two cofactors, heparin and heparan sulfate. Though several studies have been carried out on physiological, biochemical and structural perspectives on ATIII, so far there are limi...

journal_title：Biochemical and biophysical research communications

authors： Kumar A,Bhandari A,Sarde SJ,Goswami C

更新日期：2013-11-01 00:00:00

abstract：:We have previously shown that 57-kDa protein in royal jelly (RJ) was specifically degraded in proportion to both storage temperature and storage period, and we suggested that it could be useful as a marker of freshness of RJ (Kamakura, M., Fukuda, T., Fukushima, M. and Yonekura, M. (2001) Biosci. Biotechnol. Biochem. ...

journal_title：Biochemical and biophysical research communications

authors： Kamakura M,Suenobu N,Fukushima M

更新日期：2001-04-13 00:00:00

abstract：:Pro-aminopeptidase processing protease (PA protease) is an extracellular zinc metalloprotease produced by Aeromonas caviae T-64 and it is classified as M04.016 according to the MEROPS database. The precursor of PA protease consists of four regions; a signal peptide, an N-terminal propeptide, a C-terminal propeptide, a...

journal_title：Biochemical and biophysical research communications

authors： Tang B,Nirasawa S,Kitaoka M,Hayashi K

更新日期：2002-08-09 00:00:00

abstract：:The p53 tumor suppressor protein is a critical checkpoint in prevention of tumor formation, and the function of p53 is dependent on proper formation of the active tetramer. In vitro studies have shown that p53 binds DNA most efficiently as a tetramer, though inactive p53 is predicted to be monomeric in vivo. We demons...

journal_title：Biochemical and biophysical research communications

authors： Webber TM,Allen AC,Ma WK,Molloy RG,Kettelkamp CN,Dow CA,Gage MJ

更新日期：2009-06-19 00:00:00

abstract：:Copper is a micronutrient that is required for proper metabolic functioning of most prokaryotic and eukaryotic organisms. To sustain an adequate supply of copper, a cell requires molecular mechanisms that control the metal content to avoid copper toxicity. This toxicity comes primarily from the reactivity of copper, w...

journal_title：Biochemical and biophysical research communications

authors： Latorre M,Olivares F,Reyes-Jara A,López G,González M

更新日期：2011-03-25 00:00:00

abstract：:Dietary copper-deficiency in rats produced a organ-specific decrease of copper content. This was paralleled by a decrease of the activity of the copper-enzyme superoxide dismutase. In liver such a decrease is partially due to the existence of an apo-form of superoxide dismutase, which can be reactivated by addition of...

journal_title：Biochemical and biophysical research communications

authors： Rossi L,Ciriolo MR,Marchese E,De Martino A,Giorgi M,Rotilio G

更新日期：1994-09-15 00:00:00

abstract：:The Saccharomyces cerevisiae gene VPS35 encodes a component of the retromer complex which is involved in vesicle transport from endosomes to the trans-Golgi network. Yeast and human VPS35 orthologs are highly conserved and mutations in human VPS35 cause an autosomal dominant form of late-onset Parkinson disease (PD). ...

journal_title：Biochemical and biophysical research communications

authors： Sowada N,Stiller B,Kubisch C

更新日期：2016-08-05 00:00:00

abstract：:A question whether MAP1 and MAP2 (the major microtubule associated proteins from mammalian brain) bind to common or distinct sites on the microtubule surface was studied. Microtubules were assembled from tubulin and MAP1 and then centrifuged through a layer of MAP2 solution under conditions where no repolymerization o...

journal_title：Biochemical and biophysical research communications

authors： Kuznetsov SA,Rodionov VI,Gelfand VI,Rosenblat VA

更新日期：1984-02-29 00:00:00

abstract：:Interleukin (IL)-18 bioactivity and dsRNA sensing by receptors of innate immunity are key components of anti-viral host defense. Despite extensive data on signal transduction activated by both pathways knowledge on cross-communication is incomplete. By using human PBMC and predendritic KG1 cells, as prototypic IL-18-r...

journal_title：Biochemical and biophysical research communications

authors： Balah A,Akool el-S,Bachmann M,Pfeilschifter J,Mühl H

更新日期：2009-11-27 00:00:00

abstract：:Myosin light chain kinase (MLCK) is a multifunctional regulatory protein of smooth muscle contraction [IUBMB Life 51 (2001) 337, for review]. The well-established mode for its regulation is to phosphorylate the 20 kDa myosin light chain (MLC 20) to activate myosin ATPase activity. MLCK exhibits myosin-binding activity...

journal_title：Biochemical and biophysical research communications

authors： Gao Y,Kawano K,Yoshiyama S,Kawamichi H,Wang X,Nakamura A,Kohama K

更新日期：2003-05-23 00:00:00

abstract：:Endothelial growth factors have become the target of intense research since the initial discovery of vascular endothelial growth factor (VEGF/VPF). At present, VEGF is established as a major inducer of angiogenesis in normal and pathological conditions. Recently several new members in the VEGF family have been describ...

journal_title：Biochemical and biophysical research communications

authors： Farnebo F,Piehl F,Lagercrantz J

更新日期：1999-04-21 00:00:00

abstract：:High level of palmitate is associated with metabolic disorders. We recently showed that enhanced level of S-palmitoylated cytosolic thioredoxin (Trx1) in mouse liver was new characteristic feature of insulin resistance. However, our understanding of the effect of S-palmitoylation on Trx1 is limited, and the tissue spe...

journal_title：Biochemical and biophysical research communications

authors： Xu Z,Zhong L

更新日期：2015-05-15 00:00:00

abstract：:Retroviral gene transfer of dominant selectable markers into hematopoietic cells can be used to select genetically modified cells in vivo or to attenuate the toxic effects of chemotherapeutic agents. We show that retroviral gene transfer of thymidylate synthase (TS) confers resistance to TS directed anticancer agents ...

journal_title：Biochemical and biophysical research communications

authors： Fantz CR,Shaw D,Moore JG,Spencer HT

更新日期：1998-02-04 00:00:00

abstract：:Escherichia coli isoleucyl-tRNA synthetase has been shown to contain two enzyme-bound zinc atoms per polypeptide chain. To investigate the structural and functional significance of the C-terminal enzyme-bound zinc, mutagenesis was used to alter Cys 922 to Ser [IleRS(C922S)] and to replace Cys 922 through Ala 939 with ...

journal_title：Biochemical and biophysical research communications

authors： Zhou L,Rosevear PR

更新日期：1995-11-13 00:00:00

abstract：:Mitogen-activated protein kinases (MPKs) are involved in a number of signaling pathways that control plant development and stress tolerance via the phosphorylation of target molecules. However, so far only a limited number of target molecules have been identified. Here, we provide evidence that MYB41 represents a new ...

journal_title：Biochemical and biophysical research communications

authors： Hoang MH,Nguyen XC,Lee K,Kwon YS,Pham HT,Park HC,Yun DJ,Lim CO,Chung WS

更新日期：2012-05-25 00:00:00

abstract：:A fast kinetics, spectroscopic technique has been applied to the study of the transient cation flux associated to the binding of cholinergic agonist to native acetylcholine receptor (AcChR)-rich membrane vesicles in presence of anti-AcChR antibodies. The technique is based on the collisional quenching of an intravesic...

journal_title：Biochemical and biophysical research communications

authors： Gonzalez-Ros JM,Ferragut JA,Martinez-Carrion M

更新日期：1984-04-30 00:00:00

abstract：:Fission yeast cell division is initiated by the cdc2/cdc13-cyclin protein kinase which in its catalytically active state comprises the mitotic inducer. During interphase the cdc2/cyclin complex is assembled in an inactive state that requires cdc25+ gene function for M-phase activation. The cdc25+ product, a 76 kd phos...

journal_title：Biochemical and biophysical research communications

authors： Ducommun B,Draetta G,Young P,Beach D

更新日期：1990-02-28 00:00:00

abstract：:Modulation of autophagy is a new paradigm in cancer therapeutics. Recently a novel function of chloroquine (CLQ) in inhibiting degradation of autophagic vesicles has been revealed, which raises the question whether CLQ can be used as an adjuvant in targeting autophagic pro-survival mechanism in prostate cancer (PCa). ...

journal_title：Biochemical and biophysical research communications

authors： Kaini RR,Hu CA

更新日期：2012-08-24 00:00:00

abstract：:GA733 is a murine IgG2a monoclonal antibody (MAb) against human gastric carcinoma and is highly tumoricidal in nude mice. The GA733 antigen is a cell surface protein with two subunits of 30,000 and 40,000 daltons. The antigen isolated by immunoaffinity chromatography consists mainly of the 30,000-dalton subunit which ...

journal_title：Biochemical and biophysical research communications

authors： Ross AH,Herlyn D,Iliopoulos D,Koprowski H

更新日期：1986-02-26 00:00:00

abstract：:The effect that several substances may have on ANF release by atrial slices and on its tissular content was investigated. alpha- and beta-adrenergic and cholinergic agonists, vasopressin, met-enkephaline, dexamethasone and DOC, in concentration ranging from 10(-4) to 10(-8) M, were added into the incubation media and ...

journal_title：Biochemical and biophysical research communications

authors： Lachance D,Garcia R,Gutkowska J,Cantin M,Thibault G

更新日期：1986-03-28 00:00:00

abstract：:Most in vivo studies on the conversion to insulin-producing cells with AAV carrying PDX1 gene are performed in rodents. However, there is little information regarding Adeno-associated virus (AAV) carrying PDX1 gene transduced to human liver in vivo because accidental death caused by unpredicted factors cannot be denie...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto H,Mizushima T,Ogura T,Kagawa T,Tomiyama K,Takahashi R,Yagoto M,Kawai K,Chijiwa T,Nakamura M,Suemizu H

更新日期：2016-09-23 00:00:00

abstract：:This study was designed to compare the temporal changes of gene expression profile in osteoblastic cell lines (SaOS-2) treated with low-intensity pulsed ultrasound stimulation (LIPUS) using complementary DNA (cDNA) microarrays. SaOS-2 cells were treated with LIPUS for 20min. Thereafter, cells were harvested and RNA wa...

journal_title：Biochemical and biophysical research communications

authors： Lu H,Qin L,Lee K,Cheung W,Chan K,Leung K

更新日期：2009-01-16 00:00:00

abstract：:Murine cell-derived MLV vector particles usually are highly sensitive to human complement-mediated lysis. Expression of the human complement inhibitor CD59 on murine packaging cells resulted in partial protection of these cells from lysis caused by human complement proteins. Furthermore, CD59 was incorporated into MLV...

journal_title：Biochemical and biophysical research communications

authors： Breun S,Salmons B,Günzburg WH,Baumann JG

更新日期：1999-10-14 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) catalyzes the rate-limiting step in the generation of prostanoids, and is thus one of the key players in the inflammatory process. Contrary to the constitutively expressed isoform COX-1, the expression of COX-2 is rapidly and transiently upregulated following pathological stimuli but little is...

journal_title：Biochemical and biophysical research communications

authors： Brender S,Barki-Harrington L

更新日期：2014-08-22 00:00:00

abstract：:Transgenic mice expressing nuclear sterol regulatory element-binding protein-1a under the control of the insulin promoter were generated to determine the role of SREBP-1a in pancreatic beta-cells. Only low expressors could be established, which exhibited mild hyperglycemia, impaired glucose tolerance, and reduced plas...

journal_title：Biochemical and biophysical research communications

authors： Iwasaki Y,Iwasaki H,Yatoh S,Ishikawa M,Kato T,Matsuzaka T,Nakagawa Y,Yahagi N,Kobayashi K,Takahashi A,Suzuki H,Yamada N,Shimano H

更新日期：2009-01-16 00:00:00

abstract：:Explaining why type I collagens are preferentially preserved in the geological time scale remains a challenge. Several pieces of evidence indicate that its rich content in the bone and its unique, stable structure played key roles in its preservation. By considering the distinct thermal stability of amino acids, we re...

journal_title：Biochemical and biophysical research communications

authors： Wang SY,Cappellini E,Zhang HY

更新日期：2012-05-25 00:00:00