MAP2 competes with MAP1 for binding to microtubules.

abstract：:Replication of mammalian chromosomes depends on the activation of a large number of origins of DNA replication distributed along the chromosomes. We have focused our attention on a human DNA region, named ARSH1, localized to chromosome 2, that had been previously shown to act as an episomal origin in the yeast Sacchar...

journal_title：Biochemical and biophysical research communications

authors： Hu L,Xu X,Valenzuela MS

更新日期：2004-01-23 00:00:00

abstract：:Alpha-crystallin high-molecular-weight (HMW) aggregates can be formed in vitro by many mechanisms, but the mechanism of in vivo aggregation has not been clearly established. HMW and LMW (low-molecular-weight) alpha-crystallins were isolated from human lenses 50-60 years of age and some spectroscopic measurements were ...

journal_title：Biochemical and biophysical research communications

authors： Liang JJ,Akhtar NJ

更新日期：2000-08-28 00:00:00

abstract：:Low voltage-activated, rapidly inactivating T-type Ca(2+) channels are found in a variety of cells where they regulate electrical activity and Ca(2+) entry. In whole-cell patch clamp recordings from bovine adrenal zona fasciculata cells, cis-polyunsaturated omega-3 fatty acids including docosahexaenoic acid (DHA), eic...

journal_title：Biochemical and biophysical research communications

authors： Danthi SJ,Enyeart JA,Enyeart JJ

更新日期：2005-02-11 00:00:00

abstract：:In many apoptotic cells, phosphatidylserine (PS), that is normally restricted to the inner membrane layer, is externalized and subsequently recognized by phagocytes. However, it has been unclear whether PS externalization is sufficient for phagocytosis induction. In a cultured cell line undergoing Fas-mediated apoptos...

journal_title：Biochemical and biophysical research communications

authors： Shiratsuchi A,Osada S,Kanazawa S,Nakanishi Y

更新日期：1998-05-19 00:00:00

abstract：:Partially purified trehalose phosphorylase (EC 2.4.1.64) from Euglena gracilis SM-ZK was inhibited by fructose 2,6-bisphosphate in both synthetic and degradative directions. Ki value for trehalose phosphorolysis was 1.2 microM and that for trehalose synthesis was 0.5 microM. Functions of fructose 2,6-bisphosphate in E...

journal_title：Biochemical and biophysical research communications

authors： Miyatake K,Kuramoto Y,Kitaoka S

更新日期：1984-08-16 00:00:00

abstract：:The cytotoxicity of 1-methyl-4-phenylpyridinium (MPP+) is believed to arise as a consequence of its time- and energy-dependent accumulation inside mitochondria, followed by inhibition of electron transport at Complex I of the respiratory chain. Consistent with our proposal that the accumulation of MPP+ represents a pa...

journal_title：Biochemical and biophysical research communications

authors： Sayre LM,Wang F,Hoppel CL

更新日期：1989-06-15 00:00:00

abstract：:In plants, a number of MAP kinase (MAPK), MAPK kinase (MAPKK), and MAPKK kinase (MAPKKK) homologues have been reported. However, there have been no reports of protein-protein interactions between these kinases or molecular analysis of MAPK cascades in higher plants. To analyze a possible MAPK cascade in Arabidopsis th...

journal_title：Biochemical and biophysical research communications

authors： Ichimura K,Mizoguchi T,Irie K,Morris P,Giraudat J,Matsumoto K,Shinozaki K

更新日期：1998-12-18 00:00:00

abstract：AIM:To investigate the effect of endogenous PTH deficiency on osteoclasts during fracture healing and its mechanism. METHODS:A femoral fracture model was used to determine the role of endogenous PTH in fracture healing. Immunohistochemistry, qPCR, and Western blot were used to determine the potential functions and mec...

journal_title：Biochemical and biophysical research communications

authors： Sun P,Wang M,Yin GY

更新日期：2020-05-14 00:00:00

abstract：:A murine IgG mAb, WR321, selected for the ability to bind to phosphatidylinositol-4-phosphate and phosphatidylinositol-4,5-bisphosphate, but an inability to bind to any of 17 other lipids, including phosphatidylinositol, was examined as a probe for studying interactions of HIV-1 with primary human peripheral blood mon...

journal_title：Biochemical and biophysical research communications

authors： Matyas GR,Wieczorek L,Bansal D,Chenine AL,Sanders-Buell E,Tovanabutra S,Kim JH,Polonis V,Alving CR

更新日期：2010-11-26 00:00:00

abstract：:Cancer metastasis involves tumor cells invading the surrounding tissue. Remodeling of tissue barriers depends on the ability of tumor cells to degrade the surrounding collagen matrix and then migrate through the matrix defects. Epidermal growth factor (EGF) has been shown to regulate tumor cell invasion through activa...

journal_title：Biochemical and biophysical research communications

authors： Binker MG,Binker-Cosen AA,Richards D,Oliver B,Cosen-Binker LI

更新日期：2009-02-06 00:00:00

abstract：:Satellite cells that reside on the myofibre surface are crucial for the muscle homeostasis and regeneration. Aging goes along with a less effective regeneration of skeletal muscle tissue mainly due to the decreased myogenic capability of satellite cells. This phenomenon impedes proper maintenance and contributes to th...

journal_title：Biochemical and biophysical research communications

authors： Di Filippo ES,Mancinelli R,Pietrangelo T,La Rovere RM,Quattrocelli M,Sampaolesi M,Fulle S

更新日期：2016-04-29 00:00:00

abstract：:Individual yeast colonies produce pulses of volatile ammonia separated by phases of medium acidification. Colonies of Saccharomyces cerevisiae mutant defective in the general amino acid permease, Gap1p, exhibit decreased ammonia production. Mutations in the S. cerevisiae amino acid sensor SPS completely abolish the co...

journal_title：Biochemical and biophysical research communications

authors： Zikánová B,Kuthan M,Ricicová M,Forstová J,Palková Z

更新日期：2002-06-28 00:00:00

abstract：:Two peptide analogs of the 37-62 sequence region of the HIV TAT protein bind tightly to the surface of A431 breast carcinoma cells. After conjugation to either of two poorly internalized anti-tumor antibody Fab fragments, the analogs enhanced the in vitro cell surface retention and internalization of the Fab fragments...

journal_title：Biochemical and biophysical research communications

authors： Anderson DC,Nichols E,Manger R,Woodle D,Barry M,Fritzberg AR

更新日期：1993-07-30 00:00:00

abstract：:The role of osteoblasts in inducing the proliferation and differentiation of bone marrow cells was examined. Conditioned medium obtained from mouse osteoblastic cell (MC3T3-E1) cultures stimulated colony formation of mouse bone marrow cells (CSF) and differentiation of mouse myeloid leukemia cells (M1) into macrophage...

journal_title：Biochemical and biophysical research communications

authors： Shiina-Ishimi Y,Abe E,Tanaka H,Suda T

更新日期：1986-01-14 00:00:00

abstract：:In several inflammatory conditions such as rheumatoid arthritis or sepsis, the regulatory mechanisms of inflammation are inefficient and the excessive inflammatory response leads to damage to the host. Sirtuins are class III histone deacetylases that modulate the activity of several transcription factors that are impl...

journal_title：Biochemical and biophysical research communications

authors： Fernandes CA,Fievez L,Neyrinck AM,Delzenne NM,Bureau F,Vanbever R

更新日期：2012-04-20 00:00:00

abstract：:We studied about the physicochemical stability of a novel heparin-binding growth/differentiation factor, midkine (MK). It was found that synthetic human MK was heat and acid stable. Neither incubation at 80 degrees C for 90 sec nor treatment at low pH affected the elution profile of MK molecule on the high performance...

journal_title：Biochemical and biophysical research communications

authors： Kojima S,Inui T,Muramatsu H,Kimura T,Sakakibara S,Muramatsu T

更新日期：1995-11-13 00:00:00

abstract：:Bovine retinal rod outer segment membranes are enriched in a phosphoinositide-specific phosphodiesterase (phospholipase C) activity strictly modulated by free calcium ion concentration. The enzyme(s) was highly active on phosphatidylinositol 4,5-bisphosphate: maximal hydrolysis rate was attained at 10(-5)M Ca2+ and ac...

journal_title：Biochemical and biophysical research communications

authors： Panfoli I,Morelli A,Pepe I

更新日期：1990-11-30 00:00:00

abstract：:Fas-associated protein with death domain (FADD) has been implicated in T lymphocytes, but the nature of FADD-dependent mechanism in early T cell development has not been completely elucidated. In this study, using T-cell specific deletion mice, we observed that FADD deficiency in thymocytes led to increased apoptosis ...

journal_title：Biochemical and biophysical research communications

authors： Zhang XY,Yang BY,Wang JY,Mo X,Zhang J,Hua ZC

更新日期：2014-08-22 00:00:00

abstract：:The mutant of virus is a frequent event. Hepatitis B virus X protein (HBx) plays a vital role in the development of hepatocellular carcinoma (HCC). Therefore, the identification of potent mutant of HBx in hepatocarcinogenesis is significant. Previously, we identified a natural mutant of the HBx gene (termed HBxΔ127). ...

journal_title：Biochemical and biophysical research communications

authors： Liu F,You X,Chi X,Wang T,Ye L,Niu J,Zhang X

更新日期：2014-02-07 00:00:00

abstract：:Hypoxia-inducible factors are crucial in the regulatory process of oxygen homeostasis of vertebrate cells. Inhibition of prolyl hydroxylation of HIF-alpha subunits by prolyl-hydroxylases (PHD1, PHD2 and PHD3) leads to transcription of a greater number of hypoxia responsive genes. We have investigated the subcellular d...

journal_title：Biochemical and biophysical research communications

authors： Steinhoff A,Pientka FK,Möckel S,Kettelhake A,Hartmann E,Köhler M,Depping R

更新日期：2009-10-02 00:00:00

abstract：:Calyculin A (CL-A), a toxin isolated from the marine sponge Discodermia calyx, is a strong inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). Although CL-A is known to induce rapid neurite retraction in developing neurons, the cytoskeletal dynamics of this retraction have remained unclear. Here, we investigated t...

journal_title：Biochemical and biophysical research communications

authors： Inutsuka A,Goda M,Fujiyoshi Y

更新日期：2009-12-25 00:00:00

abstract：:Amphotericin B (AmB) is a potent antifungal agent used to treat patients with systemic mycoses. The cytotoxicity of AmB is related to its binding to membrane sterols and its clinical usefulness is based on its greater affinity to ergosterol, the fungal sterol, compared to the mammalian cell sterol, cholesterol (1-3). ...

journal_title：Biochemical and biophysical research communications

authors： Gruda I,Gauthier E,Elberg S,Brajtburg J,Medoff G

更新日期：1988-08-15 00:00:00

abstract：:Cultured chinese hamster lung fibroblasts, and a variant clone selected for resistance to 8-azaguanine, that lacks hypoxanthine-guanine phosphoribosyl transferase (EC 2.4.2.8), have been tested for the ability to convert 8-azaguanine into 8-azaguanosine-5'-monophosphate via purine nucleoside phosphorylase and nucleosi...

journal_title：Biochemical and biophysical research communications

authors： Tozzi MG,Camici M,Falcone V,Turriani M,Turchi G,Ipata PL

更新日期：1989-03-15 00:00:00

abstract：:Heat shock cognate protein 70 (HSC70) has been shown to bind to the peptide corresponding to amino acids 197 to 216 of human T-cell lymphotropic virus type I (HTLV-I) envelope protein, gp46, and an anti-HSC70 monoclonal antibody (mAb) inhibits HTLV-I-induced syncytium formation. These findings suggest that HSC70 is ne...

journal_title：Biochemical and biophysical research communications

authors： Fang D,Haraguchi Y,Jinno A,Soda Y,Shimizu N,Hoshino H

更新日期：1999-08-02 00:00:00

abstract：:Studies of islet neogenesis have suggested that the regeneration of islet cells can be achieved through redifferentiation of pre-existing islet cells. However, this hypothesis is largely unproven and fails to account for the diversity of observed islet neogenesis. Here we show that cultured neonatal pancreatic cells d...

journal_title：Biochemical and biophysical research communications

authors： Zhao W,Hirose T,Ishikawa M,Oshima Y,Hirai S,Ohno S,Taniguchi H

更新日期：2007-01-05 00:00:00

abstract：:Retroviruses and retrotransposons depend on their host cells to complete their replication cycles. In many cases, the viral step of reverse transcription is blocked when host cells are arrested in their cell cycle and this block is only released when the host cell resumes division. It has previously been shown that a ...

journal_title：Biochemical and biophysical research communications

authors： Karst SM,Sadeghi N,Menees TM

更新日期：1999-01-27 00:00:00

abstract：:Inhibition experiments with D-mannose oligosaccharides establish that conglutinin recognises terminal alpha 1----2 mannobiosyl units present in the glycopeptide of the alpha-chain of the complement component C3b. On the basis of its three domain structure and the homology of its N-terminal amino-acid sequence to that ...

journal_title：Biochemical and biophysical research communications

authors： Young NM,Leon MA

更新日期：1987-03-13 00:00:00

abstract：:The molecular mechanism of smooth muscle contraction was approached by a novel method, covalent 14C-labeling. Intra- and intermolecular protein interactions during contractile activity are reflected by changed reactivity of protein side chains; these can be detected by reagents which readily permeate through the muscl...

journal_title：Biochemical and biophysical research communications

authors： Bárány K,Polyák E,Bárány M

更新日期：1992-09-16 00:00:00

abstract：:This is the first systematic study on the pancreatic beta cell function in the heterozygous mouse with targeted disruption of the beta cell glucokinase gene. The heterozygotes' beta cell displayed the following characteristics: (1) impaired glucose sensitivity with normal glucose responsiveness, (2) poor discriminatio...

journal_title：Biochemical and biophysical research communications

authors： Aizawa T,Asanuma N,Terauchi Y,Suzuki N,Komatsu M,Itoh N,Nakabayashi T,Hidaka H,Ohnota H,Yamauchi K,Yasuda K,Yazaki Y,Kadowaki T,Hashizume K

更新日期：1996-12-13 00:00:00

abstract：:Ubiquitin C-terminal hydrolase-L3 (UCH-L3) is among the deubiquitinating enzymes (DUBs) that cleave ubiquitin (Ub) from Ub precursors or protein substrates. Many DUBs have been shown to participate in cancer progression in various tissues. However, the mechanism and role of UCH-L3 in carcinogenesis has largely been un...

journal_title：Biochemical and biophysical research communications

authors： Song HM,Lee JE,Kim JH

更新日期：2014-09-26 00:00:00