Myomir dysregulation and reactive oxygen species in aged human satellite cells.

Abstract:

:Satellite cells that reside on the myofibre surface are crucial for the muscle homeostasis and regeneration. Aging goes along with a less effective regeneration of skeletal muscle tissue mainly due to the decreased myogenic capability of satellite cells. This phenomenon impedes proper maintenance and contributes to the age-associated decline in muscle mass, known as sarcopenia. The myogenic potential impairment does not depend on a reduced myogenic cell number, but mainly on their difficulty to complete a differentiation program. The unbalanced production of reactive oxygen species in elderly people could be responsible for skeletal muscle impairments. microRNAs are conserved post-transcriptional regulators implicated in numerous biological processes including adult myogenesis. Here, we measure the ROS level and analyze myomiR (miR-1, miR-133b and miR-206) expression in human myogenic precursors obtained from Vastus lateralis of elderly and young subjects to provide the molecular signature responsible for the differentiation impairment of elderly activated satellite cells.

authors

Di Filippo ES,Mancinelli R,Pietrangelo T,La Rovere RM,Quattrocelli M,Sampaolesi M,Fulle S

doi

10.1016/j.bbrc.2016.03.030

subject

Has Abstract

pub_date

2016-04-29 00:00:00

pages

462-70

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(16)30343-6

journal_volume

473

pub_type

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