Binding of anti-acetylcholine receptor antibodies inhibits the acetylcholine receptor mediated cation flux.

abstract：:Lung fibrosis is a common and serious complication of radiation therapy for lung cancer, for which there are no efficient treatments. Emerging evidence indicates that lysophosphatidic acid (LPA) and its receptors (LPARs) are involved in the pathogenesis of fibrosis. Here, we reported that thoracic radiation with 16Gy ...

journal_title：Biochemical and biophysical research communications

authors： Gan L,Xue JX,Li X,Liu DS,Ge Y,Ni PY,Deng L,Lu Y,Jiang W

更新日期：2011-05-27 00:00:00

abstract：:The physiological importance of the intestinal plasma membrane calcium pump, isoform 1, (Pmca1, Atp2b1), in calcium absorption and homeostasis has not been previously demonstrated in vivo. Since global germ-line deletion of the Pmca1 in mice is associated with embryonic lethality, we selectively deleted the Pmca1 in i...

journal_title：Biochemical and biophysical research communications

authors： Ryan ZC,Craig TA,Filoteo AG,Westendorf JJ,Cartwright EJ,Neyses L,Strehler EE,Kumar R

更新日期：2015-11-06 00:00:00

abstract：:The ribonucleotide reductase from the strictly anaerobic methanogen Methanobacterium thermoautotrophicum has been partially purified by ion-exchange and gel-filtration chromatography. Its molecular weight is estimated to be 100,000 by the latter step. Unlike all previously studied ribonucleotide reductases, the enzyme...

journal_title：Biochemical and biophysical research communications

authors： Sze IS,McFarlan SC,Spormann A,Hogenkamp HP,Follmann H

更新日期：1992-04-30 00:00:00

abstract：:Polyclonal antibodies (pAbs) to riboflavin carrier protein (RCP) purified from human amniotic fluid were raised in two rabbits. These pAbs apart from recognizing the parent antigen, reacted significantly with chicken RCP as well. When all the 212 octapeptides overlapping by one amino acid residue and covering the enti...

journal_title：Biochemical and biophysical research communications

authors： Subramanian S,Adiga PR

更新日期：1999-08-27 00:00:00

abstract：:Ubiquitin-conjugating enzyme E2S (UBE2S) plays pivotal roles in the progression of human cancers. However, its clinical significance and role in hepatocellular carcinoma (HCC) remain unknown. Here, we show that UBE2S is upregulated in HCC and exhibits oncogenic activities via enhancing the ubiquitination of p53. Incre...

journal_title：Biochemical and biophysical research communications

authors： Pan YH,Yang M,Liu LP,Wu DC,Li MY,Su SG

更新日期：2018-09-05 00:00:00

abstract：:Hepatocyte growth factor, which is now known to be the same protein as scatter factor, induced oligonucleosomal fragmentation of nuclear DNA of Sarcoma 180 cells and increased the activity of caspase-3, a key component in control of the apoptotic cell death pathway to about 2.6 times that in control cells on 48 hr inc...

journal_title：Biochemical and biophysical research communications

authors： Arakaki N,Kazi JA,Kazihara T,Ohnishi T,Daikuhara Y

更新日期：1998-04-07 00:00:00

abstract：:The fluorescence decay of adenosine in 1:1 glycol/water glass has been determined at 77K using narrow pulse (700 ps) laser excitation at 290 nm and fluorescence detection with a scanned narrow-gate (100 ps) fast sampler together with digital averaging. Data analysis by re-iterative non-linear least squares convolution...

journal_title：Biochemical and biophysical research communications

authors： Hart LP,Daniels M

更新日期：1989-07-31 00:00:00

abstract：:Alpha-L-fucosidase was purified from the bull seminal plasma by chromatography on DEAE-disk, octyl sepharose hydrophobic column and HPLC. The enzyme appeared to be pure as judged by the polyacrylamide gel electrophoresis both under the nondenaturing and denaturing conditions. The pure enzyme promoted the acrosome reac...

journal_title：Biochemical and biophysical research communications

authors： Srivastava PN,Arbtan K,Takei GH,Huang TT,Yanagimachi R

更新日期：1986-06-30 00:00:00

abstract：:Glutaredoxin 3 (GLRX3) is a member of monothiol glutaredoxins with a CGFS active site that has been demonstrated to function in cellular iron sensing and trafficking via its bound iron-sulfur cluster. Human GLRX3 has been shown to form a dimer that binds two bridging [2Fe-2S] clusters with glutathione (GSH) as a ligan...

journal_title：Biochemical and biophysical research communications

authors： Xia H,Li B,Zhang Z,Wang Q,Qiao T,Li K

更新日期：2015-09-25 00:00:00

abstract：:A series of C-terminal linear peptides of endothelin (ET)-1 and their N alpha-succinyl (Suc) analogs were synthesized and their binding affinities for the two subtypes of ET receptor, ETA and ETB, in porcine lung membranes were examined. Among the synthetic analogs, Suc-[Glu9,Ala11,15]-ET-1(8-21), IRL 1620, was the mo...

journal_title：Biochemical and biophysical research communications

authors： Takai M,Umemura I,Yamasaki K,Watakabe T,Fujitani Y,Oda K,Urade Y,Inui T,Yamamura T,Okada T

更新日期：1992-04-30 00:00:00

abstract：:Deficiency of Smad3, an intracellular mediator of TGF-β, was shown to significantly accelerate re-epithelialization of the colonic mucosa. This study was performed to investigate the molecular mechanisms by which Smad3 controls colonic epithelial cell proliferation and crypt formation. Smad3(ex8/ex8) C57BL/6 mice were...

journal_title：Biochemical and biophysical research communications

authors： Furukawa K,Sato T,Katsuno T,Nakagawa T,Noguchi Y,Tokumasa A,Yokote K,Yokosuka O,Saito Y

更新日期：2011-02-25 00:00:00

abstract：:Genotoxic agents of environmental or dietary origin may play a role in breast cancer initiation. The ability of extracts of human milk to cause mutations in S. typhimurium TA1538 and YG1019 and to induce micronuclei and DNA strand breaks in MCL-5 cells was investigated. Twenty samples from different donors were analys...

journal_title：Biochemical and biophysical research communications

authors： Martin FL,Cole KJ,Weaver G,Grover PL,Phillips DH

更新日期：1999-04-13 00:00:00

abstract：:The interactions of platelets and liposomes with the tripeptide arginine-glycine-aspartic acid (RGD) as a surface ligand (RGD liposomes) were studied. The results suggest that the presence of the RGD ligand on the liposomes results in receptor-mediated mixing of lipid and aqueous contents of the liposomes and platelet...

journal_title：Biochemical and biophysical research communications

authors： Nishiya T,Sloan S

更新日期：1996-07-05 00:00:00

abstract：:Nonalcoholic fatty liver disease, one of the most common causes of chronic liver disease, is strongly associated with metabolic syndrome. Nordihydroguaiaretic acid (NDGA) has been reported to inhibit lipoprotein lipase; however, the effect of NDGA on hepatic lipid metabolism remains unclear. We evaluated body weight, ...

journal_title：Biochemical and biophysical research communications

authors： Lee MS,Kim D,Jo K,Hwang JK

更新日期：2010-10-08 00:00:00

abstract：:Evaluation of analogs of the blocked insect myotropic neuropeptide leucopyrokinin (LPK) has demonstrated its relative insensitivity to amino acid substitution in the N-terminal in contrast to the C-terminal region. Truncated analogs of LPK without the first, second, and third N-terminal amino acids retain a significan...

journal_title：Biochemical and biophysical research communications

authors： Nachman RJ,Holman GM,Cook BJ

更新日期：1986-06-30 00:00:00

abstract：:Bovine conglutinin is a Ca(2+)-dependent serum lectin specific for N-acetylglucosamine. In the present study, we report the exon-intron organization and the sequence of 5'-regulatory region of the conglutinin gene. The coding region of conglutinin mRNA, which encoded the signal peptide and the sequence of the mature p...

journal_title：Biochemical and biophysical research communications

authors： Kawasaki N,Itoh N,Kawasaki T

更新日期：1994-01-28 00:00:00

abstract：:Estrogen-dependent diseases, especially breast cancers, are frequently treated with aromatase inhibitors. Another more recent strategy is the antisense technology. In this study, after predicting aromatase mRNA secondary structure, we describe the design, the efficiency, and the toxicity of two antisense phosphorothio...

journal_title：Biochemical and biophysical research communications

authors： Auvray P,Sourdaine P,Séralini GE

更新日期：1998-12-09 00:00:00

abstract：:During the acute phase response, synthesis of C-reactive protein and serum amyloid A is increased. To investigate whether the enhanced synthesis of these proteins are due to stimulatory effect of inflammatory mediators such as interleukin-1 (IL-1) and interleukin-6 (IL-6) produced by macrophages and monocytes, primary...

journal_title：Biochemical and biophysical research communications

authors： Moshage HJ,Roelofs HM,van Pelt JF,Hazenberg BP,van Leeuwen MA,Limburg PC,Aarden LA,Yap SH

更新日期：1988-08-30 00:00:00

abstract：:STI-571 (imatinib, Gleevec, Glivec, CGP 57148) is an inhibitor of the Abl group of protein-tyrosine kinases. One of these enzymes, the Bcr-Abl oncoprotein, results from the fusion of the BCR and ABL genes that result from the reciprocal chromosomal translocation that forms the Philadelphia chromosome. The Philadelphia...

journal_title：Biochemical and biophysical research communications

authors： Roskoski R Jr

更新日期：2003-10-03 00:00:00

abstract：:The formation of oxidized low density lipoprotein (LDL) is believed to play a significant role in the pathogenesis of atherosclerosis. Myoglobin in the presence of H(2)O(2) has been shown to catalyze LDL oxidation in vitro. It is established that an oxidatively altered form of myoglobin (Mb-H), which contains a prosth...

journal_title：Biochemical and biophysical research communications

authors： Vuletich JL,Osawa Y,Aviram M

更新日期：2000-03-24 00:00:00

abstract：:Molecular structure of the ligand binding domain of hAhR has been modelled by homology modelling techniques and used for docking simulations with dioxin and nine more xenobiotics and endogenous ligands. The study evidences that different sites may bind these ligands, whereas only one binding site has been previously i...

journal_title：Biochemical and biophysical research communications

authors： Salzano M,Marabotti A,Milanesi L,Facchiano A

更新日期：2011-09-23 00:00:00

abstract：:The liver enriched transcription factors HNF-3 and HNF-4 are known to play major roles in development and differentiation of hepatocytes. STAT-3 and STAT-5 are signaling peptides activated by a variety of cytokines and growth factors including HGF and EGF. Their role in hepatocyte growth and differentiation is yet to ...

journal_title：Biochemical and biophysical research communications

authors： Runge D,Runge DM,Drenning SD,Bowen WC Jr,Grandis JR,Michalopoulos GK

更新日期：1998-09-29 00:00:00

abstract：:Although the first members of the Schlafen gene family were first described almost 10 years ago, the precise molecular/biochemical functions of the proteins they encode still remain largely unknown. Roles in cell growth, haematopoietic cell differentiation, and T cell development/maturation have, with some experimenta...

journal_title：Biochemical and biophysical research communications

authors： Neumann B,Zhao L,Murphy K,Gonda TJ

更新日期：2008-05-23 00:00:00

abstract：:Low temperatures cause cellular damage in flower buds of the sweet cherry (Prunus avium L. cv. Satohnishiki). In this study, the redox states within the cherry buds suffering freezing damage were non-destructively observed by a unique in vivo electron spin resonance (ESR) technique with a spin probe such as carbamoyl-...

journal_title：Biochemical and biophysical research communications

authors： Tada M,Shiraishi T,Takashina T,Ohya H,Ogata T

更新日期：2003-10-10 00:00:00

abstract：:2,3 Dehydro-2-deoxy-N-acetyl-neuraminic acid (DNANA) competitively inhibits the neuraminidase activity of Hemagglutinin-neuraminidase (HN) from Sendai virus. The inhibition constant depends on the presence of the Fusion (F) protein, which is 30 microM in the presence of active F protein and 50 microM when the F protei...

journal_title：Biochemical and biophysical research communications

authors： Dallocchio F,Tomasi M,Bellini T

更新日期：1995-03-08 00:00:00

abstract：:Ectopic over-expression of nucleophosmin/B23 caused a marked up-regulation in the amounts of Yin Yang 1 (YY1) and proliferating cellular nuclear antigen (PCNA) proteins. Transfection with nucleophosmin/B23-targeting siRNA induced a decrease in the intracellular amounts of nucleophosmin/B23, YY1, and PCNA. PCNA express...

journal_title：Biochemical and biophysical research communications

authors： Weng JJ,Yung BY

更新日期：2005-09-30 00:00:00

abstract：:Epigenetics plays a role in the regulation of gene expression. Epigenetic changes control gene expression at the transcriptional level. Our previous study suggested that the La protein, which is mainly localized in the nucleus, was associated with hepatitis A virus (HAV) internal ribosomal entry site (IRES)-mediated t...

journal_title：Biochemical and biophysical research communications

authors： Kanda T,Sasaki R,Nakamoto S,Haga Y,Nakamura M,Shirasawa H,Okamoto H,Yokosuka O

更新日期：2015-10-23 00:00:00

abstract：:Preincubation of cultured rat pituitary cells with 10 micrograms/ml of either wheat germ agglutinin (WGA) or concanavalin A inhibited LH release stimulated with GnRH (0.5 nM) by 55% and 40%, respectively. WGA-inhibition of LH release stimulated by GnRH was dose-dependent, reaching a plateau of 75% inhibition at 50 mic...

journal_title：Biochemical and biophysical research communications

authors： Schvartz I,Hazum E

更新日期：1986-10-30 00:00:00

abstract：:The kallikrein family (KLK) has been implicated in cancer and may be useful as tumor markers. Here, we compared the 15 KLK genes' expression in malignant and normal breast tissues using real-time quantitative PCR. Most KLKs were expressed at lower levels in breast cancer compared to normal breast tissue. The only exce...

journal_title：Biochemical and biophysical research communications

authors： Mangé A,Desmetz C,Berthes ML,Maudelonde T,Solassol J

更新日期：2008-10-10 00:00:00

abstract：:A few decades ago, researchers found emerging evidence showing that a number of sequential events lead to the pathological cascade of Alzheimer's disease (AD) which is caused by the accumulation of amyloid beta (Aβ), a physiological peptide, in the brain. Therefore, regulation of Aβ represents a crucial treatment appr...

journal_title：Biochemical and biophysical research communications

authors： Oh JH,Choi S,Shin J,Park JS

更新日期：2016-09-02 00:00:00