The effect of interleukin-1, interleukin-6 and its interrelationship on the synthesis of serum amyloid A and C-reactive protein in primary cultures of adult human hepatocytes.

abstract：:Binge drinking is the consumption of large volumes of alcohol in short periods and exerts its effects on the central nervous system, including the hippocampus. We have previously shown that binge drinking alters mitochondrial dynamics and induces neuroinflammation in the hippocampus of adolescent rats. Mild traumatic ...

journal_title：Biochemical and biophysical research communications

authors： Mira RG,Lira M,Quintanilla RA,Cerpa W

更新日期：2020-07-30 00:00:00

abstract：:We have investigated the subcellular localization of the inwardly rectifying K+ channel subunit Kir6.1 (uKATP-1). Immunoblot analysis of the mitochondrial fractions prepared from rat skeletal muscle and liver detected a single band of Kir6.1 at 51 kDa, the intensity of which was stronger than that found in the total h...

journal_title：Biochemical and biophysical research communications

authors： Suzuki M,Kotake K,Fujikura K,Inagaki N,Suzuki T,Gonoi T,Seino S,Takata K

更新日期：1997-12-29 00:00:00

abstract：:The activation of c-jun N-terminal kinase (JNK) in pancreatic islets is associated with impaired function and viability, and JNK inhibitory peptides (JNKIs) are cytoprotective. In particular, l-isoforms of JNKIs were shown to improve islets viability, while the d-retroinverso isoform of JNKI (RI-JNKI), with a higher t...

journal_title：Biochemical and biophysical research communications

authors： Fornoni A,Cobianchi L,Sanabria NY,Pileggi A,Molano RD,Ichii H,Rosero S,Inverardi L,Ricordi C,Pastori RL

更新日期：2007-03-02 00:00:00

abstract：:The recognition and removal of interstrand cross-links is perhaps the least understood of all repair pathways in eukaryotic cells. We have shown previously that uncoupling of cross-links occurs in mammalian cell extracts and have identified a number of factors that mediate this process. However, we have not observed c...

journal_title：Biochemical and biophysical research communications

authors： Lu X,Zhang N,Vasquez K,Barton M,Legerski R

更新日期：2005-10-14 00:00:00

abstract：:Iron overload, as a risk factor for osteoporosis, can result in the up-regulation of Hepcidin, and Hepcidin knockout mice display defects in their bone microarchitecture. However, the molecular and genetic mechanisms underlying Hepcidin deficiency-derived bone loss remain unclear. Here, we show that hepcidin knockdown...

journal_title：Biochemical and biophysical research communications

authors： Jiang Y,Yan Y,Wang X,Zhu G,Xu YJ

更新日期：2016-07-15 00:00:00

abstract：:TRAIP/RNF206 plays diverse roles in cell cycle progression, DNA damage response, and DNA repair pathways. Physiological importance of TRAIP is highlighted by the identification of pathogenic mutations of TRAIP gene in patients diagnosed with primordial dwarfism. Although the diverse functions of TRAIP in the nucleus h...

journal_title：Biochemical and biophysical research communications

authors： Park IS,Han Yg,Chung HJ,Jung YW,Kim Y,Kim H

更新日期：2016-02-19 00:00:00

abstract：:In addition to its interaction at hypothalamic sites to affect feeding and energy expenditure, leptin has been shown to exhibit a proliferative response in erythropoietic cells. The functional leptin receptor is also present in pancreatic islets and we now demonstrate that a commonly used clonal insulin secreting beta...

journal_title：Biochemical and biophysical research communications

authors： Islam MS,Morton NM,Hansson A,Emilsson V

更新日期：1997-09-29 00:00:00

abstract：:Starch branching enzyme (SBE) catalyzes the cleavage of α-1,4-linkages and the subsequent transfer of α-1,4 glucan to form an α-1,6 branch point in amylopectin. We determined the crystal structure of the rice branching enzyme I (BEI) in complex with maltopentaose at a resolution of 2.2Å. Maltopentaose bound to a hydro...

journal_title：Biochemical and biophysical research communications

authors： Chaen K,Noguchi J,Omori T,Kakuta Y,Kimura M

更新日期：2012-08-03 00:00:00

abstract：:Bone is a rigid yet dynamic organ, and this dynamism is mediated by the delicate balance between osteoclastic bone resorption and osteoblastic bone formation. However, excessive activation of osteoclasts is responsible for many bone diseases such as osteoporosis, Paget disease, and tumor bone metastasis. Agents that c...

journal_title：Biochemical and biophysical research communications

authors： Zhou F,Shen Y,Liu B,Chen X,Wan L,Peng D

更新日期：2017-03-18 00:00:00

abstract：:Using a synthetic 21-residue endothelin as antigen, we have produced an antiserum for endothelin and developed a specific and sensitive radioimmunoassay (RIA) for endothelin. The minimum detection limit of the RIA was 1 pg/tube. Immunoreactive (ir-) endothelin was extracted from the culture medium by Bondelute C8 colu...

journal_title：Biochemical and biophysical research communications

authors： Naruse M,Naruse K,Kurimoto F,Horiuchi J,Tsuchiya K,Kawana M,Kato Y,Zeng ZP,Sakurai H,Demura H

更新日期：1989-04-28 00:00:00

abstract：:Several studies have demonstrated that allergic asthma can induce atherosclerosis formation in mice. Moreover, allergic asthma and atherosclerosis have been shown to be strongly associated with dyslipidemia. In this study, we investigated the underlying mechanism of allergic asthma-aggravated atherosclerosis-induced c...

journal_title：Biochemical and biophysical research communications

authors： Gao S,Wang C,Li W,Shu S,Zhou J,Yuan Z,Wang L

更新日期：2019-11-19 00:00:00

abstract：:Multidrug resistance (MDR) is a unique phenomenon in cancer patients and is commonly associated with an overexpression of the human MDR gene mdr1, which encodes an energy-dependent Mr 180 kDa membrane bound protein, known as P-glycoprotein. P-glycoprotein serves as a membrane efflux to pump the drugs out of the cancer...

journal_title：Biochemical and biophysical research communications

authors： Chu TM,Lin TH,Kawinski E

更新日期：1994-08-30 00:00:00

abstract：:Neuromedin B and neuromedin C are the novel mammalian bombesin-like peptides isolated from porcine spinal cord. We have developed highly specific and sensitive radioimmunoassays for neuromedin B and neuromedin C, and determined their regional distribution in rat central nervous system. Prior to measurements of the tis...

journal_title：Biochemical and biophysical research communications

authors： Minamino N,Kangawa K,Matsuo H

更新日期：1984-11-14 00:00:00

abstract：:Small membrane-bound extracellular organelles known as articular cartilage matrix vesicles (ACVs) participate in pathologic mineralization in osteoarthritic articular cartilage. ACVs are also present in normal cartilage, although they have no known functions other than mineralization. Recently, RNA was identified in e...

journal_title：Biochemical and biophysical research communications

authors： Mitton E,Gohr CM,McNally MT,Rosenthal AK

更新日期：2009-10-23 00:00:00

abstract：:To understand the molecular mechanisms involved in preleukemia, the suppression subtractive hybridization method was used in a murine radiation-induced thymic lymphoma model. Seventeen mRNAs overexpressed in preleukemic thymuses were identified: mouse laminin binding protein (p40/37LBP), E25 protein, Rattus norvegicus...

journal_title：Biochemical and biophysical research communications

authors： Verlaet M,Deregowski V,Denis G,Humblet C,Stalmans MT,Bours V,Castronovo V,Boniver J,Defresne MP

更新日期：2001-04-27 00:00:00

abstract：:Th2 cell differentiation is critically influenced by transcription factor GATA-3 and by various cis-acting elements including enhancers, silencers and a locus control region (LCR) in the Th2 cytokine locus. Th2 LCR-deficient Th2 cells completely lost the expression of GATA-3 and the phosphorylation of STAT6. Histone 3...

journal_title：Biochemical and biophysical research communications

authors： Hwang SS,Kim K,Lee GR

更新日期：2011-07-15 00:00:00

abstract：:Amyloid fibrils were isolated from amyloid-laden tissue obtained from a chronic hemodialysis patient with carpal tunnel syndrome. After solubilization in guanidine HCl, a significant amount of the protein was located in a homogeneous low molecular weight fraction. The protein was found to be identical to beta 2-microg...

journal_title：Biochemical and biophysical research communications

authors： Gejyo F,Yamada T,Odani S,Nakagawa Y,Arakawa M,Kunitomo T,Kataoka H,Suzuki M,Hirasawa Y,Shirahama T

更新日期：1985-06-28 00:00:00

abstract：:The effect of silkworm hemolymph on baculovirus-induced insect cell apoptosis was investigated. The addition of silkworm hemolymph into the culture medium either before or during the baculovirus infection increased the host cell longevity; however, its addition after the infection was less effective. This can be expla...

journal_title：Biochemical and biophysical research communications

authors： Rhee WJ,Park TH

更新日期：2000-04-29 00:00:00

abstract：:2,3-Oxidosqualene-lanosterol cyclase is an intrinsic microsomal protein which can be solubilized by ionic (deoxycholate) and nonionic (emulphogene) detergents with good yields. The hog-liver microsomal cyclase was purified approximately 140-fold by chromatography on DEAE-cellulose and hydroxylapatite. The partially pu...

journal_title：Biochemical and biophysical research communications

authors： Duriatti A,Schuber F

更新日期：1988-03-30 00:00:00

abstract：:This study examined whether oral administration of an arginase inhibitor regulates adipose tissue macrophage infiltration and inflammation in mice with high fat diet (HFD)-induced obesity. Male C57BL/6 mice (n = 30) were randomly assigned to control (CTL, n = 10), HFD only (n = 10), and HFD with arginase inhibitor N(ω...

journal_title：Biochemical and biophysical research communications

authors： Hu H,Moon J,Chung JH,Kim OY,Yu R,Shin MJ

更新日期：2015-08-28 00:00:00

abstract：:A heat-stable protein with antimicrobial activity was isolated from Arabidopsis thaliana plants by buffer-soluble extraction and two chromatographic procedures. The results of MALDI-TOF analysis revealed that the isolated protein shares high sequence identity with aspen SP1. To determine the exact antimicrobial proper...

journal_title：Biochemical and biophysical research communications

authors： Park SC,Lee JR,Shin SO,Park Y,Lee SY,Hahm KS

更新日期：2007-10-26 00:00:00

abstract：:Acetylation of lysine residues is conserved in all three kingdoms; however, its role in prokaryotes is unknown. Here we demonstrate that acetylation enables the reference bacterium Escherichia coli to withstand environmental stress. Specifically, the bacterium reaches higher cell densities and becomes more resistant t...

journal_title：Biochemical and biophysical research communications

authors： Ma Q,Wood TK

更新日期：2011-07-15 00:00:00

abstract：:Epicubenol and 19-hydroxyferruginol (Ferruginol) are sesquiterpenes isolated from the black heartwood of Cryptomeria japonica. Dendritic cells (DC) are specialized antigen-presenting cells that monitor the antigenic environment and activate naïve T cells. The role of DC is not only to sense danger but also to tolerize...

journal_title：Biochemical and biophysical research communications

authors： Takei M,Umeyama A,Arihara S

更新日期：2005-11-18 00:00:00

abstract：:To study how different domains of the muscle-specific intermediate filament protein, desmin, contribute to its polymerization, two of its CNBr fragments were examined as to their oligomeric structure under assembly conditions. One of these, D88, covers residues 1-88 and represents almost the entire headpiece; the othe...

journal_title：Biochemical and biophysical research communications

authors： Saeed T,Ip W

更新日期：1989-12-29 00:00:00

abstract：:Natural killer (NK) cells perform multiple biological functions including tumor cell lysis and eradicating virally infected cells. Here, we report for the first time that D-galactosyl-beta1-1' sphingosine and D-glucosyl-beta1- 1' sphingosine damage human NK cells. We show that these cells express T-cell-associated gen...

journal_title：Biochemical and biophysical research communications

authors： Maghazachi AA,Knudsen E,Jin Y,Jenstad M,Chaudhry FA

更新日期：2004-07-30 00:00:00

abstract：:A total of 951 backcross progeny have been obtained from a backcross segregating for the mouse deafness mutation, shaker-2(sh-2). Linkage analysis provides a detailed genetic map in the vicinity of sh-2 which comprises 40 backcross mice identified as recombinant within a 4 cM region. This allows construction of a cont...

journal_title：Biochemical and biophysical research communications

authors： Wakabayashi Y,Kikkawa Y,Matsumoto Y,Shinbo T,Kosugi S,Chou D,Furuya M,Jishage K,Noda T,Yonekawa H,Kominami R

更新日期：1997-05-08 00:00:00

abstract：:cDNA clones from Nicotiana plumbaginifolia have been isolated by hybridization to a yeast H+-ATPase gene. The largest one encodes a polypeptide (PMA2) of 956 amino acid residues which exhibits a homology of 73% with a limited protein sequence obtained from purified oat plasma membrane H+-ATPase (Schaller and Sussman, ...

journal_title：Biochemical and biophysical research communications

authors： Boutry M,Michelet B,Goffeau A

更新日期：1989-07-31 00:00:00

abstract：:Human Bruton's tyrosine kinase (hBtk) plays a key role in growth and metabolism of B cells, but its dysfunctions cause various B-cell malignancies. Inhibitors targeting the ATP-binding pocket of hBtk have been developed, but they have several drawbacks such as adverse side effects and occurrence of drug-resistant muta...

journal_title：Biochemical and biophysical research communications

authors： Jeong S,Sohn YK,Choi Y,Park J,Kim HS

更新日期：2020-05-21 00:00:00

abstract：:We report here on characterization of a novel human gene on chromosome 2q32, containing several ankyrin repeats and ARM domains. The gene FLJ25415, including at least 31 exons and spanning about 90kb of a gene-rich genomic region, is present in the human genome as a single copy. It seems highly conserved along the mam...

journal_title：Biochemical and biophysical research communications

authors： Occhi G,Olivieri M,Rampazzo A,Danieli GA

更新日期：2004-05-21 00:00:00

abstract：:Cytochrome P450s (CYPs) play critical role in oxidative metabolism of numerous xenobiotics and endogenous compounds. The first CYP3A subfamily member in saltwater crocodile has been cloned and modelled for three-dimensional (3D) structure. The full-length cDNA was obtained employing reverse transcription polymerase ch...

journal_title：Biochemical and biophysical research communications

authors： Tabassum R

更新日期：2019-08-27 00:00:00