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A retroviral vector capable of targeted gene transfer into cells expressing HIV envelope glycoprotein.

Abstract：

:An expression vector encoding a chimeric envelope protein composed of CD4 and ecotropic retroviral envelope glycoprotein was constructed with the aim of accomplishing targeted gene transfer into HIV-1-infected cells. The chimeric protein was efficiently expressed and transported to the surfaces of various cell types and supported HIV-1 entry into human cells. A packaging cell line producing retroviral vectors carrying chimeric envelope proteins was then established. The vector particles produced were shown to be capable of specific gene transfer into human cells expressing HIV envelope glycoprotein. Blocking experiments confirmed that the vector particles entered the cells via an interaction between the chimeric and HIV envelope proteins. This targeting vector may thus be a useful tool with which to develop effective gene therapies against HIV infection.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Suzuki S,Shimada T

doi

10.1006/bbrc.2000.2690

subject

Has Abstract

pub_date

2000-05-19 00:00:00

pages

672-6

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(00)92690-1

journal_volume

271

pub_type

杂志文章

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