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Antiangiogenic activity of 4-O-methylgallic acid from Canavalia gladiata, a dietary legume.

Abstract：

:Development of nontoxic and biologically safe antiangiogenic agent has been highlighted as a promising way to treat angiogenesis related diseases including cancer. Herein, we isolated 4-O-methylgallic acid (4-OMGA) from the seed of Canavalia gladiata, a dietary legume, on the basis of the growth inhibitory activity for bovine aortic endothelial cells (BAECs). The compound potently inhibits endothelial cell invasion and tube formation stimulated with basic fibroblast growth factor (bFGF) at low micromolar concentrations where it shows no cytotoxicity to the cells. In addition, 4-OMGA inhibits vascular endothelial cell growth factor (VEGF) production under hypoxic condition and the production of reactive oxygen species (ROS) in the endothelial cells stimulated with VEGF. These results demonstrate that 4-OMGA is a compound having potential for an antiangiogenic agent.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Jeon KS,Na HJ,Kim YM,Kwon HJ

doi

10.1016/j.bbrc.2005.03.109

subject

Has Abstract

pub_date

2005-05-20 00:00:00

pages

1268-74

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)00589-9

journal_volume

330

pub_type

杂志文章

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