IL-10 inhibits Porphyromonas gingivalis LPS-stimulated human gingival fibroblasts production of IL-6.

abstract：:The effects of 1 microM concentrations of arachidonic acid hydroperoxide (HPETES) products of 5-, 12- and 15-lipoxygenase on Na+, K(+)-ATPase activity were investigated in synaptosomal membrane preparations from rat cerebral cortex. 5-HPETE inhibited Na+, K(+)-ATPase activity by up to 67 %. In contrast, 12-HPETE and 1...

journal_title：Biochemical and biophysical research communications

authors： Foley TD

更新日期：1997-06-18 00:00:00

abstract：:This communication reports the isolation, purification and characterization of key enzymes involved in dissimilatory sulfate reduction of a sulfate reducing bacterium classified as Desulfovibrio desulfuricans subspecies desulfuricans New Jersey (NCIMB 8313) (Ddd NJ). The chosen strain, originally recovered from a corr...

journal_title：Biochemical and biophysical research communications

authors： Pereira AS,Franco R,Feio MJ,Pinto C,Lampreia J,Reis MA,Calvete J,Moura I,Beech I,Lino AR,Moura JJ

更新日期：1996-04-16 00:00:00

abstract：:This is the first study to demonstrate that the AT motif binding factor 1-A (ATBF1-A) is expressed in the crypts and the bases of villi of the small intestine and negatively regulates transcription of brush-border enzyme gene, aminopeptidase-N (APN). In situ hybridization visualized a limited ATBF1-A mRNA expression i...

journal_title：Biochemical and biophysical research communications

authors： Kataoka H,Joh T,Miura Y,Tamaoki T,Senoo K,Ohara H,Nomura T,Tada T,Asai K,Kato T,Itoh M

更新日期：2000-01-07 00:00:00

abstract：:To correlate structural data on substrates of human fibroblast collagenase with their interaction with the enzyme, we have studied: Ac-PLG-s-LLG-O-ethyl ester (I), Dnp-PLGLWA(d-Arg)-NH2 (II), AcGPEGLRVG-O-ethyl ester (III) and Succ-GPLGP-O-amidomethylcoumaryl ester (IV). Peptides I and II represent collagenase cleavag...

journal_title：Biochemical and biophysical research communications

authors： Upadhye S,Ananthanarayanan VS

更新日期：1995-10-13 00:00:00

abstract：:Genes are organized as chromatin domains and positioned in the nucleus through regions of nuclear matrix association, termed MARs. Although well-studied, the mechanisms regulating expression of the beta-globin locus remain an enigma. Here, we show that certain MAR sequences of the beta-globin locus are conserved and r...

journal_title：Biochemical and biophysical research communications

authors： Walter WR,Singh GB,Krawetz SA

更新日期：1998-01-14 00:00:00

abstract：:The intrapancreatic neuropeptide galanin has been demonstrated to lower plasma insulin levels in vivo. The effects of this peptide on insulin secretion, cytoplasmic free Ca2+ concentration and membrane potential have now been studied in vitro. Glucose-stimulated insulin secretion was inhibited by galanin under these c...

journal_title：Biochemical and biophysical research communications

authors： Ahrén B,Arkhammar P,Berggren PO,Nilsson T

更新日期：1986-11-14 00:00:00

abstract：:Signal transduction activity was markedly elevated in cancer cells as shown by the increased activity of enzymes utilizing 1-phosphatidylinositol, PI (PI 4-kinase and PI-4-phosphate 5-kinase) for the production of the second messenger inositol 1,4,5-trisphosphate, IP3, in rat hepatomas (Cancer Res. 54: 2611;5574, 1994...

journal_title：Biochemical and biophysical research communications

authors： Singhal RL,Yeh YA,Praja N,Olah E,Sledge GW Jr,Weber G

更新日期：1995-03-08 00:00:00

abstract：:The effect of silkworm hemolymph on baculovirus-induced insect cell apoptosis was investigated. The addition of silkworm hemolymph into the culture medium either before or during the baculovirus infection increased the host cell longevity; however, its addition after the infection was less effective. This can be expla...

journal_title：Biochemical and biophysical research communications

authors： Rhee WJ,Park TH

更新日期：2000-04-29 00:00:00

abstract：:Endostatin, a natural angiogenesis inhibitor, had been identified for years. It opened a new approach for cancer therapy. Sequence analysis revealed that endostatin is the NC1 domain (non-triple-helical domain) of collagen XVIII. In this report, the cDNA of NC1 domain of type VIII collagen (alpha 1) was cloned and exp...

journal_title：Biochemical and biophysical research communications

authors： Xu R,Yao ZY,Xin L,Zhang Q,Li TP,Gan RB

更新日期：2001-11-23 00:00:00

abstract：:Plastocyanin (PC) is a copper protein that serves as a mobile electron carrier between cytochrome f and Photosystem I in the light reactions of photosynthesis. Despite large variability in amino acid sequences and isoelectric points, PCs from cyanobacterial and chloroplast sources reveal considerable similarities with...

journal_title：Biochemical and biophysical research communications

authors： Babu CR,Arudchandran A,Hille R,Gross EL,Bullerjahn GS

更新日期：1997-06-27 00:00:00

abstract：:Hsp16.3, a small heat shock protein from Mycobacterium tuberculosis (MTB), was originally identified as an immuno-dominant antigen and later found to be a major membrane protein. In vitro studies show that Hsp16.3 exists as nonamers and undergoes dynamic dissociation/re-association equilibrium in solutions. Neverthele...

journal_title：Biochemical and biophysical research communications

authors： Zhang H,Fu X,Jiao W,Zhang X,Liu C,Chang Z

更新日期：2005-05-20 00:00:00

abstract：:(1S,5S,6R,7R)-7-Chloro-3-imino-5-methyl-2-azabicyclo[4.1.0]heptane hydrochloride (ONO-1714), a novel cyclic amidine analogue, inhibits human inducible nitric oxide (iNOS) with a K(i) of 1.88 nM and rodent iNOS with similar potency in vitro. ONO-1714 was found to be 10-fold selective for human iNOS over human endotheli...

journal_title：Biochemical and biophysical research communications

authors： Naka M,Nanbu T,Kobayashi K,Kamanaka Y,Komeno M,Yanase R,Fukutomi T,Fujimura S,Seo HG,Fujiwara N,Ohuchida S,Suzuki K,Kondo K,Taniguchi N

更新日期：2000-04-13 00:00:00

abstract：:l-Aspartyl (l-Asp) and l-asparaginyl residues in proteins isomerize or racemize to d,l-isoaspartyl (d,l-isoAsp) or d-aspartyl (d-Asp) residues during protein aging. These atypical aspartyl residues can interfere with the biological function of the protein and lead to cellular dysfunction. Protein l-isoaspartyl (d-aspa...

journal_title：Biochemical and biophysical research communications

authors： Kosugi S,Furuchi T,Katane M,Sekine M,Shirasawa T,Homma H

更新日期：2008-06-20 00:00:00

abstract：:Multidrug resistance (MDR) is a unique phenomenon in cancer patients and is commonly associated with an overexpression of the human MDR gene mdr1, which encodes an energy-dependent Mr 180 kDa membrane bound protein, known as P-glycoprotein. P-glycoprotein serves as a membrane efflux to pump the drugs out of the cancer...

journal_title：Biochemical and biophysical research communications

authors： Chu TM,Lin TH,Kawinski E

更新日期：1994-08-30 00:00:00

abstract：:Hepatocyte Growth Factor (HGF) was originally identified as hepatotrophic factor for liver regeneration. More recently, HGF was revealed to stimulate proliferation of various epithelial cells. At present study, we have investigated the mitogenic effect of HGF on gastric epithelial cells in the primary culture system. ...

journal_title：Biochemical and biophysical research communications

authors： Takahashi M,Ota S,Terano A,Yoshiura K,Matsumura M,Niwa Y,Kawabe T,Nakamura T,Omata M

更新日期：1993-03-15 00:00:00

abstract：:The PCR analysis followed by sequence alignment showed that both the mineralocorticoid receptor (MCR) and the epithelial sodium channel (ENaC) genes were expressed in the human vascular endothelial cell line (ECV). The growth and multiplication of the ECV in culture were influenced by both aldosterone and the MCR-spec...

journal_title：Biochemical and biophysical research communications

authors： Golestaneh N,Klein C,Valamanesh F,Suarez G,Agarwal MK,Mirshahi M

更新日期：2001-02-09 00:00:00

abstract：:One hypothesis for the etiology of Parkinson's disease (PD) is that the formation of proteinaceous inclusion, which is mainly composed of alpha-synuclein, may contribute to the selective loss of dopaminergic neurons. To further explore the role of alpha-synuclein in neurodegeneration of PD, we examined the possible ef...

journal_title：Biochemical and biophysical research communications

authors： Yu F,Xu H,Zhuo M,Sun L,Dong A,Liu X

更新日期：2005-05-27 00:00:00

abstract：:The diagnostic significance of phosphoglycerate mutase (PGM) B-type isozyme activity capable of being inducible under hypoxia at the gene level as a serum marker for cerebral stroke was investigated. The normal level (mean +/- 2 SD) in human serum was determined to be 38 +/- 18 units/L. Within 2 h after the onset of c...

journal_title：Biochemical and biophysical research communications

authors： Hayashi T,Matuo Y

更新日期：2001-10-05 00:00:00

abstract：:Alpha-/beta-dystroglycans (DG) located at the outmost layer of myelin sheath play a critical role in its formation and stability in the peripheral nerve system. The demyelination of nerve fibers is present in autoimmune neuritis, however, it is not known about the molecular mechanisms underlying this pathological proc...

journal_title：Biochemical and biophysical research communications

authors： Zhao XL,Li GZ,Sun B,Zhang ZL,Yin YH,Tian YS,Li H,Li HL,Wang de S,Zhong D

更新日期：2010-02-19 00:00:00

abstract：:Ca2+ influx from the extracellular space in nonexcitable cells occurs via receptor-operated and refilling processes. However, they showed different characteristics with respect to the Mn2+ permeability, depletion of intracellular Ca2+ stores, and sensitivity to the K+ ionophore valinomycin in rat pancreatic acinar cel...

journal_title：Biochemical and biophysical research communications

authors： Tsunoda Y,Tashiro Y

更新日期：1999-03-24 00:00:00

abstract：:Peptidyl fluoromethyl ketones, improved reagents for inactivating cysteinyl and serine proteinases, have provided unexpected results when applied to intact trypanosomes. A lethal effect was observed but limited to the infectious phase of the parasitic growth cycle. Since the inhibitors are known only to act on proteas...

journal_title：Biochemical and biophysical research communications

authors： Ashall F,Angliker H,Shaw E

更新日期：1990-07-31 00:00:00

abstract：:A 2.1-kb genomic region responsible for Ogawa serotype specificity of Vibrio cholerae 01 was identified by cosmid cloning and recombinant plasmid experiments. The plasmid carrying this region derived from Ogawa type Vibrio cholerae NIH 41 coded for a specific protein of 27 kD, and was found to convert serotype specifi...

journal_title：Biochemical and biophysical research communications

authors： Ito T,Ohshita Y,Nakamoto T,Hiramatsu K,Yokota T

更新日期：1991-03-15 00:00:00

abstract：:The mechanism by which lithium (Li(+)) inhibits the protein kinase glycogen synthase kinase-3 (GSK-3) is unknown. Here, we demonstrate that Li(+) is a competitive inhibitor of GSK-3 with respect to magnesium (Mg(2+)), but not to substrate or ATP. This mode of inhibition is conserved between mammalian and Dictyostelium...

journal_title：Biochemical and biophysical research communications

authors： Ryves WJ,Harwood AJ

更新日期：2001-01-26 00:00:00

abstract：:In Alzheimer's disease a small fragment of the amyloid protein precursor (APP), called beta 4, is a characteristic component of senile plaques in brains of affected patients. Efforts to intervene in Alzheimer's disease include approaches by which APP levels can be decreased in brain. The study described here demonstra...

journal_title：Biochemical and biophysical research communications

authors： Yang F,Jansen L,Friedrichs WE,Buchanan JM,Bowman BH

更新日期：1993-03-31 00:00:00

abstract：:Many cell types are known to synthesize nitric oxide (NO.) from L-arginine. There appear to be at least two forms of NO. synthase: an inducible, tetrahydrobiopterin- and flavin-dependent activity exemplified by the macrophage enzyme and a constitutive, Ca+(+)-dependent activity exemplified by the endothelial cell enzy...

journal_title：Biochemical and biophysical research communications

authors： Gross SS,Stuehr DJ,Aisaka K,Jaffe EA,Levi R,Griffith OW

更新日期：1990-07-16 00:00:00

abstract：:The nucleotide sequence of the 5S rRNA from a mushroom, Coprinus cinereus, was determined to be: (sequence in text). This sequence is consistent with current models for the secondary structure of 5S RNAs and indicates a very high degree of sequence conservation among the most highly evolved fungi. Sequence heterogenei...

journal_title：Biochemical and biophysical research communications

authors： Liu WY,Nazar RN

更新日期：1983-10-14 00:00:00

abstract：:Hyperphosphorylation of extracellular signal-regulated protein kinases-1/2 (ERK1/2) is known to promote cancer cell proliferation. We therefore investigated the constitutive phosphorylation levels of ERK1/2 and the expression of its downstream targets c-Fos, c-Jun, and cyclooxygenase-2 (COX-2) in biopsied human gastri...

journal_title：Biochemical and biophysical research communications

authors： Wu WK,Sung JJ,Yu L,Li ZJ,Chu KM,Cho CH

更新日期：2008-08-22 00:00:00

abstract：:PES1 (also known as Pescadillo), a nucleolar protein, was involved in biogenesis of ribosomal RNA. Up-regulation of PES1 has been documented in some human cancers, indicating that PES1 may play some crucial roles in tumorigenesis. In our previous study, it was found that silencing of PES1 resulted in decreased prolife...

journal_title：Biochemical and biophysical research communications

authors： Xie W,Qu L,Meng L,Liu C,Wu J,Shou C

更新日期：2013-02-15 00:00:00

abstract：:Affinity column-purified GABA-benzodiazepine receptor protein from bovine brain was photoaffinity labeled with both [3H]flunitrazepam and [3H]muscimol. Gel electrophoresis in sodium dodecyl sulfate revealed that the benzodiazepine binding site labeled with [3H]flunitrazepam was primarily associated with a major peptid...

journal_title：Biochemical and biophysical research communications

authors： Deng L,Ransom RW,Olsen RW

更新日期：1986-08-14 00:00:00

abstract：:Leukotrienes play an important pathophysiological role in chronic inflammatory states and, as previously shown, cause increased levels of cyclooxygenase-2 (COX-2) in intestinal epithelial cells. The anti-apoptotic protein Bcl-2 is also elevated by LTD(4) stimulation, and in colon cancer, so we studied the mechanisms o...

journal_title：Biochemical and biophysical research communications

authors： Wikström K,Ohd JF,Sjölander A

更新日期：2003-03-07 00:00:00