Abstract:
:Ca2+ influx from the extracellular space in nonexcitable cells occurs via receptor-operated and refilling processes. However, they showed different characteristics with respect to the Mn2+ permeability, depletion of intracellular Ca2+ stores, and sensitivity to the K+ ionophore valinomycin in rat pancreatic acinar cells. While Mn2+ did not enter into the cells during the refilling phase, the opposite was true in receptor-operated Ca2+ influx (ROCI) evoked by carbachol (CCh). ROCI occurred in the absence of intracellular Ca2+ release from the stores. Valinomycin abolished the second response of Ca2+ elicited by CCh, whereas it had no effect on ROCI. These observations suggest that receptor-operated Ca2+ channels (ROCCs) and refilling channels may be different in rat pancreatic acinar cells.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Tsunoda Y,Tashiro Ydoi
10.1006/bbrc.1999.0305subject
Has Abstractpub_date
1999-03-24 00:00:00pages
579-83issue
3eissn
0006-291Xissn
1090-2104pii
S0006-291X(99)90305-4journal_volume
256pub_type
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