Physical dissection of the CCAAT/enhancer-binding protein alpha in regulating the mouse amelogenin gene.

abstract：:With age human collagen demonstrates, amongst other changes, reductions in solubility, elasticity and permeability. Many of these changes have been attributed to non-enzymic glycosylation (glycation)-a spontaneous addition of sugar molecules to any protein with free amino groups. The resulting formation and accumulati...

journal_title：Biochemical and biophysical research communications

authors： Malik NS,Meek KM

更新日期：1994-03-15 00:00:00

abstract：:We attempted to attenuate neointimal formation following vascular injury using a retroviral suicide vector. Epicardial coronary arteries of adult miniature swine were injured by deployment of oversized tantalum stents. One week later, injured segments were exposed to packaged retroviral constructs with or without the ...

journal_title：Biochemical and biophysical research communications

authors： Barbee RW,Stapleton DD,Madras DE,Ré RN,Murgo JP,Davenport WD,Giardina J,Cook JL

更新日期：1995-02-06 00:00:00

abstract：:The fission yeast S-phase regulator Mcl1, an orthologue of budding yeast Ctf4, is an interacting protein of DNA polymerase alpha and an important factor to ensure DNA replication and sister chromatid cohesion. Deletion of this protein results in severe cohesion defects, however, the function and cellular role of this ...

journal_title：Biochemical and biophysical research communications

authors： Mamnun YM,Katayama S,Toda T

更新日期：2006-11-10 00:00:00

abstract：:Multidrug resistance in human tumour cells is often associated with increased expression of the 190kDa multidrug resistance protein, MRP1, that belongs to the ATP-binding cassette superfamily of transport proteins. MRP1 is also an efficient transporter of many organic anions. In the present study, we have mapped the e...

journal_title：Biochemical and biophysical research communications

authors： Koike K,Deeley RG,Cole SP

更新日期：2004-03-12 00:00:00

abstract：:Parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor expressed in rat cultured cortical type I astrocytes was identified and characterized. Northern blot analysis demonstrated that the PTH/PTHrP receptor mRNA is expressed in astrocytes. A human PTH fragment, PTH [1-34], stimulated adenylate c...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto H,Aino H,Ogawa N,Nagata S,Baba A

更新日期：1994-04-29 00:00:00

abstract：:In general, translation efficiency of ferritin mRNAs is modulated by variations in iron supply. In primary avian erythroblasts undergoing short-term proliferation, however, ferritin heavy chain (ferH) mRNA is repressed at all iron levels. Yet, expression of v-ErbA oncoprotein is sufficient to reinduce ferH mRNA utiliz...

journal_title：Biochemical and biophysical research communications

authors： Mikulits W,Schranzhofer M,Deiner EM,Beug H,Müllner EW

更新日期：2000-08-28 00:00:00

abstract：:The flavanol (-)-epicatechin has been found to protect against damage inflicted by peroxynitrite, an inflammatory intermediate. Here, epicatechin was tested in systems of increasing complexity. The compound efficiently protected against nitration of protein tyrosine residues by peroxynitrite (IC(50) approximately 0.02...

journal_title：Biochemical and biophysical research communications

authors： Schroeder P,Klotz LO,Buchczyk DP,Sadik CD,Schewe T,Sies H

更新日期：2001-07-20 00:00:00

abstract：:Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that encodes a small conductance cAMP-activated chloride ion channel. In the CF pancreatic duct, mutations in CFTR cause a reduction in bicarbonate secretion. This is thought to result from CFTR operating...

journal_title：Biochemical and biophysical research communications

authors： Hyde K,Harrison D,Hollingsworth MA,Harris A

更新日期：1999-09-24 00:00:00

abstract：:Polyamine biosynthesis pathway has long been considered an essential drug target for trypanosomatids including Leishmania. S-adenosylmethionine decarboxylase (AdoMetDc) and spermidine synthase (SpdSyn) are enzymes of this pathway that catalyze successive steps, with the product of the former, decarboxylated S-adenosyl...

journal_title：Biochemical and biophysical research communications

authors： Mishra AK,Agnihotri P,Srivastava VK,Pratap JV

更新日期：2015-01-09 00:00:00

abstract：:O-GlcNAcylation is a kind of post-translational modification and many nuclear and cytoplasmic proteins are O-GlcNAcylated. In this study, we demonstrated that thiazolidinediones (TZDs), which are used as insulin sensitizer, specifically inhibited the O-GlcNAcylation of Sp1 but did not affect the O-GlcNAcylation of the...

journal_title：Biochemical and biophysical research communications

authors： Chung SS,Kim JH,Park HS,Choi HH,Lee KW,Cho YM,Lee HK,Park KS

更新日期：2008-08-08 00:00:00

abstract：:Ascorbate and several phenolic compounds readily oxidise in cell culture media to generate hydrogen peroxide. However, addition of α-ketoglutarate, which is known to be released by several cell types, decreased the levels of H(2)O(2), and the α-ketoglutarate was depleted and converted to succinate. These observations ...

journal_title：Biochemical and biophysical research communications

authors： Long LH,Halliwell B

更新日期：2011-03-04 00:00:00

abstract：:The cytosolic sulfotransferases (SULTs) in vertebrates catalyze the sulfonation of endogenous thyroid/steroid hormones and catecholamine neurotransmitters, as well as a variety of xenobiotics, using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as the sulfonate donor. In this study, we determined the structures of SULT...

journal_title：Biochemical and biophysical research communications

authors： Lu J,Li H,Zhang J,Li M,Liu MY,An X,Liu MC,Chang W

更新日期：2010-05-28 00:00:00

abstract：:Green fluorescent protein (GFP)-tagged phospholipase C (PLC)-delta1 and its mutants were expressed in Madin-Darby canine kidney (MDCK) cells. GFP-PLC-delta1 or the GFP-tagged pleckstrin homology (PH) domain of PLC-delta1 itself was found to be predominantly localized at the plasma membrane. The DeltaPH mutant or a sit...

journal_title：Biochemical and biophysical research communications

authors： Fujii M,Ohtsubo M,Ogawa T,Kamata H,Hirata H,Yagisawa H

更新日期：1999-01-19 00:00:00

abstract：:Farnesylation of p21Ras is required for translocation to the plasma membrane and subsequent activation by growth factors. Previously we demonstrated that insulin stimulates the phosphorylation of farnesyltransferase (FTase) and its activity, whereby the amount of farnesylated p21Ras anchored at the plasma membrane is ...

journal_title：Biochemical and biophysical research communications

authors： Solomon CS,Goalstone ML

更新日期：2001-07-13 00:00:00

abstract：:Estrogen-dependent diseases, especially breast cancers, are frequently treated with aromatase inhibitors. Another more recent strategy is the antisense technology. In this study, after predicting aromatase mRNA secondary structure, we describe the design, the efficiency, and the toxicity of two antisense phosphorothio...

journal_title：Biochemical and biophysical research communications

authors： Auvray P,Sourdaine P,Séralini GE

更新日期：1998-12-09 00:00:00

abstract：:We investigated the molecular mechanism underlying the neuroprotective effect of theanine, a green tea component, using primary cultured rat cortical neurons, focusing on group I metabotropic glutamate receptors (mGluRs). Theanine and a group I mGluR agonist, DHPG, inhibited the delayed death of neurons caused by brie...

journal_title：Biochemical and biophysical research communications

authors： Nagasawa K,Aoki H,Yasuda E,Nagai K,Shimohama S,Fujimoto S

更新日期：2004-07-16 00:00:00

abstract：:The effect of capsaicin, main pungent ingredient of hot chilli peppers, in the gene expression profile of human prostate PC-3 cancer cells has been analyzed using a microarray approach. We identified 10 genes that were down-regulated and five genes that were induced upon capsaicin treatment. The data obtained from mic...

journal_title：Biochemical and biophysical research communications

authors： Sánchez AM,Martínez-Botas J,Malagarie-Cazenave S,Olea N,Vara D,Lasunción MA,Díaz-Laviada I

更新日期：2008-08-08 00:00:00

abstract：:The Shank family comprises three large multi-domain proteins playing central roles as protein scaffolds in the neuronal postsynaptic density. The Shank proteins are closely linked to neuropsychiatric diseases, such as autism spectrum disorders. One characteristic domain in the Shank family is the SH3 domain, assumed t...

journal_title：Biochemical and biophysical research communications

authors： Ponna SK,Myllykoski M,Boeckers TM,Kursula P

更新日期：2017-08-26 00:00:00

abstract：:This is the first study to demonstrate that the AT motif binding factor 1-A (ATBF1-A) is expressed in the crypts and the bases of villi of the small intestine and negatively regulates transcription of brush-border enzyme gene, aminopeptidase-N (APN). In situ hybridization visualized a limited ATBF1-A mRNA expression i...

journal_title：Biochemical and biophysical research communications

authors： Kataoka H,Joh T,Miura Y,Tamaoki T,Senoo K,Ohara H,Nomura T,Tada T,Asai K,Kato T,Itoh M

更新日期：2000-01-07 00:00:00

abstract：:18β-Glycyrrhetinic acid (18β-GA) obtained from the herb liquorice has various pharmacological properties including anti-inflammatory and anti-bacterial activities. However, potential biological anti-obesity activities are unclear. In this study, novel biological activities of 18β-GA in the adipogenesis of 3T3-L1 pread...

journal_title：Biochemical and biophysical research communications

authors： Moon MH,Jeong JK,Lee YJ,Seol JW,Ahn DC,Kim IS,Park SY

更新日期：2012-04-20 00:00:00

abstract：:The cytolytic mechanism of cholesterol-dependent cytolysins (CDCs) requires the presence of cholesterol in the target cell membrane. Membrane cholesterol was thought to serve as the common receptor for these toxins, but not all CDCs require cholesterol for binding. One member of this toxin family, pneumolysin (PLY) is...

journal_title：Biochemical and biophysical research communications

authors： Lim JE,Park SA,Bong SM,Chi YM,Lee KS

更新日期：2013-01-11 00:00:00

abstract：:Signaling pathways for the antiviral and antiproliferative biological effects of type I interferons (IFN) are well established. In this report we demonstrate a novel signaling pathway for IFN-alpha, as it induced rapid phosphorylation of both PKB/Akt and its substrate forkhead. The PI3-kinase inhibitor LY294002 abolis...

journal_title：Biochemical and biophysical research communications

authors： Ruuth K,Carlsson L,Hallberg B,Lundgren E

更新日期：2001-06-15 00:00:00

abstract：:The Triton X-100 extract of the particulate fraction of porcine spleen contains a protein kinase which can be activated by phospholipid and the phorbol ester TPA but does not respond to phospholipid and calcium. The partially purified kinase has a molecular weight of 76 kDa (p76-kinase) and hence is somewhat smaller t...

journal_title：Biochemical and biophysical research communications

authors： Gschwendt M,Leibersperger H,Marks F

更新日期：1989-11-15 00:00:00

abstract：:Messenger RNA for RII beta is transiently induced (greater than 50-fold) by cAMP analogs in primary cultures of rat Sertoli cells. The induction is dependent on protein synthesis. We have previously shown that mRNA for RII beta is stabilized by cAMP, as well as inhibitors of transcription and translation. This indicat...

journal_title：Biochemical and biophysical research communications

authors： Knutsen HK,Taskén KA,Eskild W,Hansson V

更新日期：1992-03-16 00:00:00

abstract：:The effects of cAMP on the expression of ETA (ET-1 selective type) receptor mRNA and on the response to endothelin-1 (ET-1) were investigated in rat aortic smooth muscle cells in primary culture, using reverse transcription polymerase chain reaction (RT-PCR) and fura-2 microfluorometry of cytosolic Ca2+ concentrations...

journal_title：Biochemical and biophysical research communications

authors： Nishimura J,Chen X,Jahan H,Shikasho T,Kobayashi S,Kanaide H

更新日期：1992-10-30 00:00:00

abstract：:The large subunit of the [NiFe] hydrogenases harbors a NiFe(CN)(2)(CO) cluster. Maturation proteins HypA, B, C, D, E, and F are required for the NiFe cluster biosynthesis. While the maturation machinery has been hitherto studied intensively, little is known about interactions between the Hyp proteins and the large sub...

journal_title：Biochemical and biophysical research communications

authors： Sasaki D,Watanabe S,Kanai T,Atomi H,Imanaka T,Miki K

更新日期：2012-01-06 00:00:00

abstract：:Cox-2 plays an important role in colon carcinogenesis and inflammation. Studying the HT-29 colon cancer cell line as a model, we found that Cox-2 expression and activity is increased approximately 25-fold by TNF-alpha. As previously reported for other Cox-2 inducers, this activation appears to result from a p38-mediat...

journal_title：Biochemical and biophysical research communications

authors： Tong X,Yin L,Giardina C

更新日期：2004-04-30 00:00:00

abstract：:Aggregation of the amyloid beta (Abeta) peptide yields both fibrillar precipitates and soluble oligomers, and is associated with Alzheimer's disease (AD). In vitro, Cu(2+) and Zn(2+) strongly bind Abeta and promote its precipitation. However, less is known about their interactions with the soluble oligomers, which are...

journal_title：Biochemical and biophysical research communications

authors： Garai K,Sengupta P,Sahoo B,Maiti S

更新日期：2006-06-23 00:00:00

abstract：:p53 is a well-known transcription factor that controls cell cycle arrest and cell death in response to a wide range of stresses. Moreover, p53 regulates glucose metabolism and its mutation results in the metabolic switch to the Warburg effect found in cancer cells. Nucleotide biosynthesis is also critical for cell pro...

journal_title：Biochemical and biophysical research communications

authors： Kim HR,Roe JS,Lee JE,Hwang IY,Cho EJ,Youn HD

更新日期：2012-02-24 00:00:00

abstract：:Pyruvate kinase M2 (PKM2) functions as an important rate-limiting enzyme of aerobic glycolysis that is involved in tumor initiation and progression. However, there are few studies on effective PKM2 inhibitors. Gliotoxin is a marine-derived fungal secondary metabolite with multiple biological activities, including immu...

journal_title：Biochemical and biophysical research communications

authors： Tang W,Liu ZL,Mai XY,Qi X,Li DH,Gu QQ,Li J

更新日期：2020-07-30 00:00:00