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Retroviral suicide vector does not inhibit neointimal growth in a porcine coronary model of restenosis.

Abstract：

:We attempted to attenuate neointimal formation following vascular injury using a retroviral suicide vector. Epicardial coronary arteries of adult miniature swine were injured by deployment of oversized tantalum stents. One week later, injured segments were exposed to packaged retroviral constructs with or without the herpes simplex virus thymidine kinase gene. Ganciclovir treatments were initiated 48 hours later in both control and experimental swine and continued for two weeks. Four weeks following vascular injury, both control and experimental arteries were harvested and histologically prepared for image analysis. Despite adequate marker gene expression, there was no significant difference in the neointimal area or neointimal/media ratio between control and experimental groups. While the HSVtk ganciclovir system attenuates cell proliferation in other systems, retroviral vector targeting of vascular smooth muscle cells for elimination may be too inefficient to prevent restenosis following angioplasty.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Barbee RW,Stapleton DD,Madras DE,Ré RN,Murgo JP,Davenport WD,Giardina J,Cook JL

doi

10.1006/bbrc.1995.1157

subject

Has Abstract

pub_date

1995-02-06 00:00:00

pages

89-98

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)71157-6

journal_volume

207

pub_type

杂志文章

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