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Genomic characterization and embryonic expression of the mouse Bigh3 (Tgfbi) gene.

Abstract：

:Mutations in human BIGH3 (TGFB1), a gene identified after treatment of an adenocarcinoma cell line with TGF-beta, have been observed in patients with granular Groenouw type I, Reis-Bücklers, Thiel-Behnke, Avellino, and Lattice type I and IIIa, six autosomal dominant corneal dystrophies linked to chromosome 5q. In order to gain insight into the physiological role of this gene, we characterized the genomic structure of the mouse Bigh3 and its expression in murine embryos. The gene spans 30 kb on mouse chromosome 13 and has 17 exons. Embryonic expression of Bigh3 is observed in the mesenchyme of the first and second branchial arches as early as dpc 11.5 and is particularly strong in the mesenchyme of numerous tissues throughout all the development stages. In fetal eye, the expression is first seen at 11.5 dpc in the mesenchyme surrounding the optic stalk, extends toward the sclera and choroid by 14.3 dpc and reaches the cornea by 17.5 dpc. Because the physiological role of BIGH3/Bigh3 is still largely unknown, embryonic expression in organs like heart, vessels, and intestine may help to identify new functions which could be searched for in patients and in knock-out animal models. The characterization of the murine structure is a prerequisite for the making of such models.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Schorderet DF,Menasche M,Morand S,Bonnel S,Büchillier V,Marchant D,Auderset K,Bonny C,Abitbol M,Munier FL

doi

10.1006/bbrc.2000.3116

subject

Has Abstract

pub_date

2000-08-02 00:00:00

pages

267-74

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(00)93116-4

journal_volume

274

pub_type

杂志文章

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