Differential regulation of splicing, localization and stability of mammalian ARD1235 and ARD1225 isoforms.

Abstract:

:ARD1 protein is a mammalian gene product homologous to a yeast Ard1p (Arrest defective 1 protein) acetyltransferase. Although two alternative splicing products of ARD1, ARD1(235) and ARD1(225), were reported in mouse, only ARD1(235) orthologue was reported in humans. Here we show that ARD1(225) is not expressed in humans, suggesting that factors regulating alternative splicing of ARD1 may have evolved differently between species. In human cells, hARD1(235) is shown to be present in both nucleus and cytoplasm. However, in mouse cells, mARD1(235) and mARD1(225) proteins are localized to the nucleus and cytoplasm, respectively. Moreover, during apoptosis, ARD1(235) and ARD1(225) isoforms are destabilized by different mechanisms in a species-specific manner and dependent on destabilizing reagents. These results indicate that ARD1(235) and ARD1(225) isoforms may have different activities and function in different subcellular compartments of mammalian cells.

authors

Chun KH,Cho SJ,Choi JS,Kim SH,Kim KW,Lee SK

doi

10.1016/j.bbrc.2006.11.131

subject

Has Abstract

pub_date

2007-02-02 00:00:00

pages

18-25

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)02551-4

journal_volume

353

pub_type

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