Up-regulation of p21- and RhoA-activated protein kinases in human pregnant myometrium.

abstract：:High sensitivity detection of DNA is essential for genomics. The intrinsic fluorescence from DNA is very weak and almost all methods for detecting DNA rely on the use of extrinsic fluorescent probes. We show that the intrinsic emission from DNA can be enhanced many-fold by spatial proximity to silver island films. Sil...

journal_title：Biochemical and biophysical research communications

authors： Lakowicz JR,Shen B,Gryczynski Z,D'Auria S,Gryczynski I

更新日期：2001-09-07 00:00:00

abstract：:Subcellular distribution of a novel annexin, annexin XI, was examined in rat tissues. As we have previously reported, annexin XI mainly localizes in nuclei of 3Y1, the rat embryonic fibroblast cell line; however, immunoperoxidase staining was not particularly nuclear in most of the tissues examined in adult rats. Nucl...

journal_title：Biochemical and biophysical research communications

authors： Mamiya N,Iino S,Mizutani A,Kobayashi S,Hidaka H

更新日期：1994-07-15 00:00:00

abstract：:The downregulation of gene expression by RNA interference holds great potential for genetic analysis and gene therapy. However, a more efficient delivery system for small interfering RNA (siRNA) into the target cells is required for wide fields such as cell biology, physiology, and clinical application. Non-viral vect...

journal_title：Biochemical and biophysical research communications

authors： Inoh Y,Furuno T,Hirashima N,Kitamoto D,Nakanishi M

更新日期：2011-10-28 00:00:00

abstract：:Elongation factor-1alpha plays an essential role in eukaryotic protein biosynthesis. Recently, we have shown by protein structure modeling the presence of a hairpin-loop of 12 amino acids in mammalian EF-1alpha that is absent in the leishmania homologue [D. Nandan, A. Cherkasov, R. Sabouti, T. Yi, N.E. Reiner, Molecul...

journal_title：Biochemical and biophysical research communications

authors： Lopez M,Cherkasov A,Nandan D

更新日期：2007-05-18 00:00:00

abstract：:The effects of selective inhibition of cyclic AMP phosphodiesterase type III on insulin and glucose levels during an oral glucose challenge were evaluated in obese, diabetic ob/ob mice and in lean, non-diabetic littermates using the selective inhibitor, milrinone. Oral administration of milrinone increased plasma insu...

journal_title：Biochemical and biophysical research communications

authors： Parker JC,VanVolkenburg MA,Nardone NA,Hargrove DM,Andrews KM

更新日期：1997-07-30 00:00:00

abstract：:TRAF2 is a key molecule involved in TNF signaling, which is crucial for the regulation of inflammatory processes. We have identified a novel TRAF2 binding protein, designated as T2BP (TRAF2 binding protein), by a mammalian two-hybrid screening approach. T2BP is a relatively small protein of 184 amino acids, which incl...

journal_title：Biochemical and biophysical research communications

authors： Kanamori M,Suzuki H,Saito R,Muramatsu M,Hayashizaki Y

更新日期：2002-01-25 00:00:00

abstract：:Coordinated migration of endothelial cells models the remodeling of existing endothelia as well as angiogenesis and vasculogenesis. Platelet-endothelial cell adhesion molecule-1, PECAM-1, a transmembrane endothelial adhesion protein, binds and activates the tyrosine phosphatase SHP-2 via phosphotyrosines 663 and 686. ...

journal_title：Biochemical and biophysical research communications

authors： Gratzinger D,Barreuther M,Madri JA

更新日期：2003-01-31 00:00:00

abstract：:Triple-negative breast cancer (TNBC) that lacks expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) is a breast cancer subtype with very aggressive metastasis and poor prognosis. Unique cartilage matrix-associated protein (UCMA) is a vitamin K-dependent...

journal_title：Biochemical and biophysical research communications

authors： Lee SH,Lee YJ,Park SI,Kim JE

更新日期：2020-10-01 00:00:00

abstract：:A series of C-terminal deleted analogs of human growth hormone-releasing factor (hGRF) with either an amidated or a free carboxylic acid C-terminus were synthesized by solid phase methodology. Their capacity to release growth hormone was tested on rat anterior pituitary cells in monolayer culture. A gradual decrease o...

journal_title：Biochemical and biophysical research communications

authors： Ling N,Baird A,Wehrenberg WB,Ueno N,Munegumi T,Brazeau P

更新日期：1984-09-17 00:00:00

abstract：PURPOSE:To investigate the expression profiles of IL-6 and STAT3 in Wilms' tumor (WT) and their relationship with disease progression. METHODS:Immunohistochemistry was used to examine IL-6 and STAT3 expression in 58 primary tumors and 18 invasive/metastatic ones. RESULTS:Positive expression rate of IL-6/STAT3 was 39....

journal_title：Biochemical and biophysical research communications

authors： Zhang LJ,Liu W,Gao YM,Qin YJ,Wu RD

更新日期：2013-06-07 00:00:00

abstract：:Inflammatory signals associated with cardiac diseases trigger trans-differentiation of cardiac fibroblasts to cardiac myofibroblasts. Cardiac myofibroblasts are the main cell type involved in the development of cardiac fibrosis, a diffuse and disproportionate accumulation of collagen in the myocardium. Although the ro...

journal_title：Biochemical and biophysical research communications

authors： Villa M,Cerda-Opazo P,Jimenez-Gallegos D,Garrido-Moreno V,Chiong M,Quest AF,Toledo J,Garcia L

更新日期：2020-04-09 00:00:00

abstract：:Amyloid-beta (Abeta) is the core component of senile plaques, which are the pathological markers for Alzheimer's disease and cerebral amyloid angiopathy. DNA methylation/demethylation plays a crucial role in gene regulation and could also be responsible for presentation of senescence. Oxidative stress, which may be in...

journal_title：Biochemical and biophysical research communications

authors： Chen KL,Wang SS,Yang YY,Yuan RY,Chen RM,Hu CJ

更新日期：2009-01-02 00:00:00

abstract：:The relation of expression of the LF-B1 gene with the L-type pyruvate kinase (L-PK) mRNA level in rat liver and hepatoma cells was investigated. The L-PK mRNA level in rat liver changed after partial hepatectomy, during development and on intake of a high carbohydrate diet, while the level of LF-B1 mRNA remained uncha...

journal_title：Biochemical and biophysical research communications

authors： Imai E,Noguchi T,Takenaka M,Yamada K,Matsuda T,Monaci P,Nicosia A,Tanaka T

更新日期：1991-05-15 00:00:00

abstract：:Here we describe differences in the formation of the epinephrine-induced Ca2+ transients between parent and Ki-ras-transformed NIH3T3 fibroblasts. These transients proved to be the results of an efflux from both the thapsigargin-sensitive and -insensitive intracellular pools. While the epinephrine-induced detachment o...

journal_title：Biochemical and biophysical research communications

authors： Tóth S,Fu T,Nozawa Y,Csaba G

更新日期：1993-01-29 00:00:00

abstract：:Adiponectin, an adipose-derived hormone, exhibits various biological functions, such as increasing insulin sensitivity, protecting hypertension, and suppression of atherosclerosis, liver fibrosis, and tumor growth. Here, we report the role of adiponectin on bone metabolism. C57BL/6J mice were treated with adenovirus e...

journal_title：Biochemical and biophysical research communications

authors： Oshima K,Nampei A,Matsuda M,Iwaki M,Fukuhara A,Hashimoto J,Yoshikawa H,Shimomura I

更新日期：2005-06-03 00:00:00

abstract：:Monoclonal antibody BB1 was previously shown to recognize the CD80 protein as well as a putative B7.3 molecule, both ligands of the important T-cell receptors CD28 and CTLA-4. We report that BB1 coprecipitated from detergent lysates of human B- and pre-B-cell lines a protein kinase activity, as detected by solid phase...

journal_title：Biochemical and biophysical research communications

authors： Angelisová P,Cerný J,Horejsí V

更新日期：1996-11-12 00:00:00

abstract：:Previous studies showed that biotin enhanced glucose-induced insulin secretion. Changes in the cytosolic ATP/ADP ratio in the pancreatic islets participate in the regulation of insulin secretion by glucose. In the present study we investigated whether biotin regulates the cytosolic ATP/ADP ratio in glucose-stimulated ...

journal_title：Biochemical and biophysical research communications

authors： Sone H,Sasaki Y,Komai M,Toyomizu M,Kagawa Y,Furukawa Y

更新日期：2004-02-13 00:00:00

abstract：:The omega-3 fatty acid eicosapentaenoic acid (EPA) reduces oxidation of ApoB-containing particles in vitro and in patients with hypertriglyceridemia. EPA may produce these effects through a potent antioxidant mechanism, which may facilitate LDL clearance and slow plaque progression. We hypothesize that EPA antioxidant...

journal_title：Biochemical and biophysical research communications

authors： Sherratt SCR,Mason RP

更新日期：2018-02-05 00:00:00

abstract：:The nonsense-mediated decay (NMD) pathway selectively degrades mRNAs carrying a premature translation-termination codon but also regulates the abundance of a large number of physiological mRNAs that encode full-length proteins. In human cells, NMD-targeted mRNAs are degraded by endonucleolytic cleavage and exonucleoly...

journal_title：Biochemical and biophysical research communications

authors： da Costa PJ,Menezes J,Saramago M,García-Moreno JF,Santos HA,Gama-Carvalho M,Arraiano CM,Viegas SC,Romão L

更新日期：2019-10-22 00:00:00

abstract：:We have reported that the principal neutralizing domain of V3 of the HIV-1 gp120 induces an antigen-specific activation apoptosis of responding effector CD4+ T lymphocytes, a phenomenon inhibited by RANTES, an agonist of CCR5. Here, addressing the question of how a hypervariable region could induce such a selective re...

journal_title：Biochemical and biophysical research communications

authors： Baritaki S,Zafiropoulos A,Sioumpara M,Politis M,Spandidos DA,Krambovitis E

更新日期：2002-11-08 00:00:00

abstract：:Signal transduction by transforming growth factor-beta (TGF-beta) involves the formation of a heteromeric complex of two transmembrane serine/threonine kinase receptors, type I (T beta R-I) and type II (T beta R-II). In the region preceeding the kinase domain of T beta R-I there is a glycine- and serine-rich sequence,...

journal_title：Biochemical and biophysical research communications

authors： Franzén P,Heldin CH,Miyazono K

更新日期：1995-02-15 00:00:00

abstract：:The stability and catalytic efficacy of the L-2-haloacid dehalogenase isolated from Azotobacter sp. RC26 were studied after immobilisation on a DEAE Sephacel solid matrix. While the optimum temperature for the soluble dehalogenase falls in the range of 30-40 degrees C, the activity of the immobilised enzyme shows a fo...

journal_title：Biochemical and biophysical research communications

authors： Diez A,Prieto MI,Alvarez MJ,Bautista JM,Garrido J,Puyet A

更新日期：1996-03-27 00:00:00

abstract：:The activity of the enzyme tyrosine aminotransferase and the synthesis of its specific mRNA were evaluated at different hours of the day in the liver of 3-, 12- and 24-month old BN rats. The enzyme activity has a circadian rhythm with a peak at midnight in 3- and 12-month old, which shifts to 03.00 hrs in 24-month old...

journal_title：Biochemical and biophysical research communications

authors： Servillo G,Della Fazia MA,Viola-Magni M

更新日期：1991-02-28 00:00:00

abstract：:Lipocalin-type prostaglandin D synthase (L-PGDS) is one of the most abundant proteins in human cerebrospinal fluid (CSF) with dual functions as a prostaglandin D2 (PGD2) synthase and a transporter of lipophilic ligands. Recent studies revealed that L-PGDS plays important roles in protecting against various neuronal di...

journal_title：Biochemical and biophysical research communications

authors： Qin S,Shimamoto S,Maruno T,Kobayashi Y,Kawahara K,Yoshida T,Ohkubo T

更新日期：2015-12-04 00:00:00

abstract：:Data on a new entity which inhibits the release of luteinizing hormone (LH), designated as factor C-LHIH, are presented. In vitro assays were carried out with pituitary glands from female rats. Factor C-LHIH and follicle stimulating hormone releasing hormone (FSHRH) initially fractionated together. FSHRH obscured C...

journal_title：Biochemical and biophysical research communications

authors： Johansson KN,Greibrokk T,Currie BL,Hansen J,Folkers K

更新日期：1975-03-03 00:00:00

abstract：:This is the first study to demonstrate that the AT motif binding factor 1-A (ATBF1-A) is expressed in the crypts and the bases of villi of the small intestine and negatively regulates transcription of brush-border enzyme gene, aminopeptidase-N (APN). In situ hybridization visualized a limited ATBF1-A mRNA expression i...

journal_title：Biochemical and biophysical research communications

authors： Kataoka H,Joh T,Miura Y,Tamaoki T,Senoo K,Ohara H,Nomura T,Tada T,Asai K,Kato T,Itoh M

更新日期：2000-01-07 00:00:00

abstract：:Recent work identified an RNA binding protein whose presence in brain tumors correlated with translational repression of Glut1 expression. RNase T1 mapping demonstrated that this protein bound an AU-rich response element (AURE) in the Glut1 3'UTR. Facilitated by its differential expression in brain tumor cytosols, we ...

journal_title：Biochemical and biophysical research communications

authors： Hamilton BJ,Nichols RC,Tsukamoto H,Boado RJ,Pardridge WM,Rigby WF

更新日期：1999-08-11 00:00:00

abstract：:We have previously observed that extracellular Mg2+ influences the phosphofructokinase (PFK) activity of intact Ehrlich Ascites tumour cells (EATC). In this study we have investigated the mechanism by which Mg2+ modulates this key glycolytic enzyme in EATC made permeable to the cation by either digitonin or dextran su...

journal_title：Biochemical and biophysical research communications

authors： Wolf FI,Bossi D,Cittadini A

更新日期：1991-09-16 00:00:00

abstract：:Pseudohypoaldosteronism type II (PHAII), an autosomal dominant disorder characterized by hypertension, hyperkalemia, and hyperchloremic acidosis, is reportedly due to mutations in WNK1 and WNK4 kinase genes. However, the pathogenesis of the disease remains unknown. Mutations in the WNK1 gene are the deletions in the f...

journal_title：Biochemical and biophysical research communications

authors： Ohta A,Yang SS,Rai T,Chiga M,Sasaki S,Uchida S

更新日期：2006-10-20 00:00:00

abstract：:Mitochondrial reactive oxygen species (ROS) are associated with multiple cellular functions such as cell proliferation, differentiation, and apoptosis. In particular, high levels of mitochondrial ROS in hypoxic cells regulate many angiogenesis-related diseases, including cancer and ischemic disorders. Here we report a...

journal_title：Biochemical and biophysical research communications

authors： Kim KH,Park JY,Jung HJ,Kwon HJ

更新日期：2011-01-07 00:00:00