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β-cell serotonin production is associated with female sex, old age, and diabetes-free condition.

Abstract：

:Serotonin is known to be present in pancreatic β-cells and to play several physiological roles, including insulin secretion, β-cell proliferation, and paracrine inhibition of α-cells. However, the serotonin production of different cell lines and islets has not been compared based on age, sex, and diabetes related conditions. Here, we directly compared the serotonin concentrations in βTC and MIN6 cell lines, as well as in islets from mice using ultra-performance liquid chromatography tandem mass spectrometry. The average serotonin concentration was 5-10 ng/mg protein in the islets of male and non-pregnant female mice. The serotonin level was higher in females than males at 8 weeks, although there was no difference at 1 year. Furthermore, we observed serotonin by immunofluorescence staining in the pancreatic tissues of mice and human. Serotonin was detected by immunofluorescence staining in a portion of β-cells from islets of old female mice, but not of male or young female mice. A similar pattern was observed in human pancreas as well. In humans, serotonin production in β-cells was associated with a diabetes-free condition. Thus, serotonin production in β-cells was associated with old age, female sex, and diabetes-free condition.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kim YG,Moon JH,Kim K,Kim H,Kim J,Jeong JS,Lee J,Kang S,Park JS,Kim H

doi

10.1016/j.bbrc.2017.09.130

subject

Has Abstract

pub_date

2017-11-25 00:00:00

pages

1197-1203

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(17)31911-3

journal_volume

493

pub_type

杂志文章

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