Signal peptide protection by specific chaperone.

Abstract:

:TorD is the private chaperone of TorA, a periplasmic respiratory molybdoenzyme of Escherichia coli. In this study, it is demonstrated that TorD is required to maintain the integrity of the twin-arginine signal sequence of the cytoplasmic TorA precursors. In the absence of TorD, 35 out of the 39 amino acid residues of the signal peptide were lost and the proteolysis of the N-terminal extremity of TorA precursors was not prevented by the molybdenum cofactor insertion. We thus propose that one of the main roles of TorD is to protect the TorA signal peptide to allow translocation of the enzyme by the TAT system.

authors

Genest O,Seduk F,Ilbert M,Méjean V,Iobbi-Nivol C

doi

10.1016/j.bbrc.2005.11.107

subject

Has Abstract

pub_date

2006-01-20 00:00:00

pages

991-5

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)02646-X

journal_volume

339

pub_type

杂志文章
  • Characterization of receptor tyrosine-specific protein kinases by the use of inhibitors. Staurosporine is a 100-times more potent inhibitor of insulin receptor than IGF-I receptor.

    abstract::The receptors for insulin and insulin-like growth factor (IGF)-I carry intrinsic tyrosine-specific protein kinases (TPK) in their cytoplasmic domains that show 84% homology. Our previous studies using tyrosine-containing synthetic polymers (Arch. Biochem. Biophys. 260, 416, 1988) revealed subtle differences between th...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/s0006-291x(88)80967-7

    authors: Fujita-Yamaguchi Y,Kathuria S

    更新日期:1988-12-30 00:00:00

  • Production of soluble integrin alpha2beta1 heterodimer complex functionally active in vitro and in vivo.

    abstract::Integrin alpha2beta1, which is a membrane protein consisting of noncovalently bound alpha2 and beta1 chains, mediates cell binding to collagen and plays a role in platelet functions. DNAs encoding the chimeric proteins in which the extracellular domains of each alpha2 and beta1 chain was fused to hinge and Fc regions ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.2001.6195

    authors: Kainoh M,Tanaka T

    更新日期:2002-01-11 00:00:00

  • C-propeptide region of human pro alpha 1 type 1 collagen interacts with thioredoxin.

    abstract::Thioredoxin (TRX) is one of major components of thiol reducing systems. To investigate the molecular mechanism of TRX function in the lung tissue, we screened a human lung epithelial cell cDNA library for TRX-binding protein by yeast two-hybrid systems. We isolated a plasmid containing C-propeptide region of human pro...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/s0006-291x(02)00727-1

    authors: Matsumoto K,Masutani H,Nishiyama A,Hashimoto S,Gon Y,Horie T,Yodoi J

    更新日期:2002-07-19 00:00:00

  • Growth-inhibitory effects of 1,25-dihydroxyvitamin D3 on normal human keratinocytes cultured in serum-free medium.

    abstract::The effect of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on the growth of normal human keratinocytes cultured in serum-free medium was investigated. 1,25(OH)2D3 inhibited the cell growth at 10(-7) M by 75.3% and at 10(-6) M almost completely. The growth inhibition was accompanied by changes related to proliferation: (1) r...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(90)90898-w

    authors: Matsumoto K,Hashimoto K,Nishida Y,Hashiro M,Yoshikawa K

    更新日期:1990-01-30 00:00:00

  • NF-κB subunit RELA suppression of mucosa-associated lymphoid tissue lymphoma translocation protein 1 expression in oral carcinoma cells.

    abstract::Loss of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) expression closely associates with increased aggressive behaviors of oral carcinoma cells. It emphasizes that a mechanism to suppress the expression is an important subject for understanding carcinoma progression pathway. However, nothi...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2021.01.025

    authors: Nozawa T,Mihara-Tomiyama N,Chiba T,Imai K

    更新日期:2021-01-19 00:00:00

  • Structural organization of the human selenium-dependent phospholipid hydroperoxide glutathione peroxidase gene (GPX4): chromosomal localization to 19p13.3.

    abstract::The primary structure of human selenium-dependent phospholipid hydroperoxide glutathione peroxidase (GPX4) was determined by genomic cloning. The gene structure of GPX4 spans only 2.8 kb and consists of 7 exons. The coding sequence resides on all 7 exons, and the mitochondrial leader sequence is contained entirely wit...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1998.9086

    authors: Kelner MJ,Montoya MA

    更新日期:1998-08-10 00:00:00

  • Homology-modeled ligand-binding domains of medaka estrogen receptors and androgen receptors: a model system for the study of reproduction.

    abstract::Estrogen and androgen and their receptors play critical roles in physiological processes such as sexual differentiation and development. Using the available structural models for the human estrogen receptors alpha and beta and androgen receptor as templates, we designed in silico agonist and antagonist models of medak...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2009.01.047

    authors: Cui J,Shen X,Yan Z,Zhao H,Nagahama Y

    更新日期:2009-02-27 00:00:00

  • Age-related changes in the activities of antioxidant enzymes and lipid peroxidation status in ventral and dorsolateral prostate lobes of noble rats.

    abstract::In this investigation, the activities of five enzymes (catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, glucose-6-dehydrogenase) involved in oxygen radical (OR)-detoxification and antioxidative defense were measured in conjunction with an index of lipid peroxidation in major prostatic lob...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1996.0749

    authors: Ghatak S,Ho SM

    更新日期:1996-05-15 00:00:00

  • Trypanosome H2Bv replaces H2B in nucleosomes enriched for H3 K4 and K76 trimethylation.

    abstract::Some inroads have been made into characterizing histone variants and post translational modifications of histones in Trypanosoma brucei. Histone variant H2BV lysine 129 is homologous to Saccharomyces cerevisiae H2B lysine 123, whose ubiquitination is required for methylation of H3 lysines 4 and 79. We show that T. bru...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2008.01.144

    authors: Mandava V,Janzen CJ,Cross GA

    更新日期:2008-04-18 00:00:00

  • Partial structure of the human H-protein gene.

    abstract::In a span of approximately 13 kb, two genomic fragments showing an obvious overlap encoded the 1,192 base pair (bp) cDNA sequence for human H-protein. Because of the close similarity in the genomic organization comprised of five exons to that for the chicken H-protein gene, this region was assigned to the true H-prote...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(91)91001-s

    authors: Koyata H,Hiraga K

    更新日期:1991-08-15 00:00:00

  • AMPK activators contribute to maintain naïve pluripotency in mouse embryonic stem cells.

    abstract::Pluripotent stem cells retain the property to self-renew and differentiate into all cell types under defined conditions. Among mouse embryonic stem cells (ESCs), which are pluripotent but heterogenous in gene expression and morphology, an ESC population cultured in small molecule inhibitors of two kinases, MAPK/ERK ki...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2018.11.164

    authors: Liu Y,Yamashita JK

    更新日期:2019-01-29 00:00:00

  • Derivation of cranial neural crest-like cells from human embryonic stem cells.

    abstract::The neural crest is a transient population of multipotent progenitors contributing to a diverse array of tissues throughout the vertebrate embryo. Embryonic stem (ES) cells are able to form embryoid body and spontaneously differentiate to various lineages, following a reproducible temporal pattern of development that ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2008.09.032

    authors: Zhou Y,Snead ML

    更新日期:2008-11-21 00:00:00

  • Identification of polymorphic sites of the human bradykinin B2 receptor gene.

    abstract::The characterization of the genomic organization of the B2 bradykinin receptor gene enabled us to systematically search for polymorphic markers in this gene in a South German cohort (N = 179). We identified at least three polymorphic sites in each of the three exons existing: (i) in exon 1 next to the promoter region,...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1995.1801

    authors: Braun A,Kammerer S,Böhme E,Müller B,Roscher AA

    更新日期:1995-06-06 00:00:00

  • Protein phosphorylation by inorganic pyrophosphate in yeast mitochondria.

    abstract::Inorganic pyrophosphate can function as phosphate donor in protein phosphorylation reactions in yeast mitochondria. It was shown that, when PPi substitutes for ATP as inhibitor of the pyruvate dehydrogenase reaction, maximal activity is reached after a lag-period of 30-60 minutes. 32P-labeling of peptides shows that [...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(91)91043-c

    authors: da Silva LP,Lindahl M,Lundin M,Baltscheffsky H

    更新日期:1991-08-15 00:00:00

  • STI-571 inhibits in vitro angiogenesis.

    abstract::Compounds that block angiogenesis are effective in the treatment of certain cancers and other angiogenesis-related diseases. Many of these compounds specifically target the rapidly proliferating and migrating endothelial cell. However, angiogenesis is a multi-faceted process involving heterotypic interactions between ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2003.08.129

    authors: Dudley A,Gilbert RE,Thomas D,Cox A,Price JT,Best J,Jenkins A

    更新日期:2003-10-10 00:00:00

  • Electron microscopic single particle analysis of a tetrameric RuvA/RuvB/Holliday junction DNA complex.

    abstract::During the late stage of homologous recombination in prokaryotes, RuvA binds to the Holliday junction intermediate and executes branch migration in association with RuvB. The RuvA subunits form two distinct complexes with the Holliday junction: complex I with the single RuvA tetramer on one side of the four way juncti...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2007.10.165

    authors: Mayanagi K,Fujiwara Y,Miyata T,Morikawa K

    更新日期:2008-01-11 00:00:00

  • Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo.

    abstract::PML-RARalpha is a chimeric transcription factor tightly associated with acute promyelocytic leukemia. PML-RARalpha plays an important role in the aberrant transcription repression on the target genes of wild-type retinoic acid receptors. Here, we demonstrated that HDAC3, one component of the N-CoR transcription repres...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2006.05.047

    authors: Atsumi A,Tomita A,Kiyoi H,Naoe T

    更新日期:2006-07-14 00:00:00

  • Inhibition of gastric pepsin secretion by peripherally or centrally injected interleukin-1 in rats.

    abstract::The present study was carried out to investigate the effects of Interleukin-1 (IL-1) on gastric pepsin secretion in conscious pylorus-ligated rats. The intraperitoneal (ip) injection of IL-1 resulted in a dose-related inhibition of gastric pepsin output. The intracerebroventricular (icv) injection of IL-1 similarly re...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(90)90616-u

    authors: Okumura T,Uehara A,Okamura K,Takasugi Y,Namiki M

    更新日期:1990-03-30 00:00:00

  • DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras.

    abstract::We have isolated and characterized the cDNA encoding a novel protein designated DJ-1. DJ-1, sharing no significant homology with the sequences so far reported, did not show transactivation activity in the Gal4 recombinant system, but transformed mouse NIH3T3 cells by itself. Furthermore, DJ-1 showed a cooperative tran...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1997.6132

    authors: Nagakubo D,Taira T,Kitaura H,Ikeda M,Tamai K,Iguchi-Ariga SM,Ariga H

    更新日期:1997-02-13 00:00:00

  • Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1.

    abstract::XAF1 (XIAP-associated factor 1) binds to XIAP and blocks its anti-apoptotic activity. It has been reported that XAF1 is mainly expressed in normal tissues but is missing or present at low levels in most cancer cell lines, which implies a tumor-suppressing function. In the present study we describe the identification o...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2005.11.128

    authors: Yin W,Cheepala S,Clifford JL

    更新日期:2006-01-27 00:00:00

  • Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2.

    abstract::Inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2 are upregulated in many cancer cells. Several compounds targeting IAPs and inducing cell death in cancer cells have been developed. Some of these are synthesized mimicking the N-terminal tetrapeptide sequence of Smac/DIABLO, the natural endogenous I...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2008.10.139

    authors: Cossu F,Mastrangelo E,Milani M,Sorrentino G,Lecis D,Delia D,Manzoni L,Seneci P,Scolastico C,Bolognesi M

    更新日期:2009-01-09 00:00:00

  • Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease.

    abstract::The liver X receptor (LXR) functions as a receptor for oxysterols and plays a critical role in the regulation of glucose and lipid metabolism. We recently described a synthetic LXR inverse agonist that displayed efficacy in treatment of hepatic steatosis in a mouse model of non-alcoholic fatty liver disease (NAFLD). T...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2016.09.036

    authors: Griffett K,Burris TP

    更新日期:2016-10-21 00:00:00

  • Restoration and stimulation of the in vitro immune response of B cells to sheep erythrocytes by interleukins and muramyl dipeptide (MDP).

    abstract::MDP, a synthetic muramyl dipeptide, is capable of increasing the primary in vitro antibody response, to sheep erythrocytes, of purified B cells restored with a monokine and helper T cell factors, including Interleukin 2 and the late-acting T cell replacing factor (TRF). First, the possibility that the adjuvanticity of...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/s0006-291x(84)80386-1

    authors: Souvannavong V,Adam A

    更新日期:1984-11-30 00:00:00

  • MicroRNA-144-3p suppresses gastric cancer progression by inhibiting epithelial-to-mesenchymal transition through targeting PBX3.

    abstract::MicroRNAs are aberrantly expressed in a wide variety of human cancers. The present study aims to elucidate the effects and molecular mechanisms of miR-144-3p that underlie gastric cancer (GC) development. It was observed that miR-144-3p expression was significantly decreased in GC tissues compared to that in paired no...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2017.01.084

    authors: Li B,Zhang S,Shen H,Li C

    更新日期:2017-03-04 00:00:00

  • Identification of a novel growth hormone binding protein mRNA in rat liver.

    abstract::The presence of highly specific serum binding proteins for growth hormone (GH) has been well characterized in many species. In the rat the major growth hormone-binding protein (GH-BP) is a truncated, variant form of the target tissue GH receptor and is derived by an alternative mRNA splicing event. The GHBP mRNA is co...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/s0006-291x(05)81091-5

    authors: Tiong TS,Herington AC

    更新日期:1991-10-31 00:00:00

  • FBXO11 represses cellular response to hypoxia by destabilizing hypoxia-inducible factor-1α mRNA.

    abstract::The transcriptional factor hypoxia-inducible factor-1α (HIF-1α) is induced under hypoxia and plays crucial roles in cancer progression and angiogenesis. Protein arginine methyltransferases (PRMTs), 11 isoforms of which have been identified so far, modulates the functions of diverse proteins by catalyzing arginine meth...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2015.07.037

    authors: Ju UI,Park JW,Park HS,Kim SJ,Chun YS

    更新日期:2015-09-04 00:00:00

  • Demonstration of a leptin binding factor in human serum.

    abstract::Serum leptin levels are elevated in subjects with exogenous obesity, indicating that obesity is associated with leptin resistance. Since in man no abnormalities have yet been found in either the genes for leptin or its receptor, the mechanism of leptin resistance in obesity remains unknown. To determine if resistance ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1997.6538

    authors: Diamond FB Jr,Eichler DC,Duckett G,Jorgensen EV,Shulman D,Root AW

    更新日期:1997-04-28 00:00:00

  • Lipid peroxidation as a possible cause of TCDD toxicity.

    abstract::The target tissues of TCDD, the dysfunctions that result in death in experimental animals, and the ultimate biochemical lesion(s) caused by TCDD are not known despite numerous studies. We have shown by the thiobarbituric acid and conjugated diene methods that TCDD induces hepatic lipid peroxidation in rats. The lipid ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(83)91377-3

    authors: Stohs SJ,Hassan MQ,Murray WJ

    更新日期:1983-03-29 00:00:00

  • argJ mutations are highly inducible by ethidium bromide in proB strains of Streptomyces lividans: implication of pathway interactions.

    abstract::Spontaneous Arg- mutants arose at high frequencies in Streptomyces lividans. Exposure to ethidium bromide increased the frequency of arg instability. In Pro+ strains the induced arg mutants were mainly argG, but in the proB mutants, a new mutation, argJ, prevailed which lacked ornithine acetyltransferase activity and ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(92)92318-r

    authors: Chou CF,Chen CW

    更新日期:1992-12-15 00:00:00

  • An antifungal protein from ginger rhizomes.

    abstract::There are very few reports on antifungal proteins from rhizomes and there is none from the family of Zingiberaceae. An antifungal protein with a novel N-terminal sequence was isolated from ginger rhizomes utilizing a protocol that involved ion exchange chromatography on DEAE-cellulose, affinity chromatography on Affi-...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2005.08.058

    authors: Wang H,Ng TB

    更新日期:2005-10-14 00:00:00