A genetic polymorphism in the promoter region of DRD4 associated with expression and schizophrenia.

abstract：:Here we report that we could obtain a highly differentiated smooth muscle cell line by screening the expression of a-smooth muscle actin from p53 knook out mice aorta. This cell revealed extended bipolar shape and expressed h-caldesmon and calponin as well as a-smooth muscle actin as protein markers of differentiated ...

journal_title：Biochemical and biophysical research communications

authors： Ohmi K,Masuda T,Yamaguchi H,Sakurai T,Kudo Y,Katsuki M,Nonomura Y

更新日期：1997-09-08 00:00:00

abstract：:TorD is the private chaperone of TorA, a periplasmic respiratory molybdoenzyme of Escherichia coli. In this study, it is demonstrated that TorD is required to maintain the integrity of the twin-arginine signal sequence of the cytoplasmic TorA precursors. In the absence of TorD, 35 out of the 39 amino acid residues of ...

journal_title：Biochemical and biophysical research communications

authors： Genest O,Seduk F,Ilbert M,Méjean V,Iobbi-Nivol C

更新日期：2006-01-20 00:00:00

abstract：:Circular dichroism (CD) spectra of class II MHC peptides revealed the alpha-helical conformation of superantigen-binding peptides I-A beta b(60-90), I-A beta b(65-85), and I-A alpha b(51-80), but not the nonbinding peptide I-A beta b(80-100). These CD spectra provide biophysical evidence for the alpha-helicity of clas...

journal_title：Biochemical and biophysical research communications

authors： Russell JK,Jarpe MA,Johnson HM

更新日期：1992-02-14 00:00:00

abstract：:Vomeronasal organs of female Wistar rats were exposed with sprayed urine preparations of male Wistar rats prior to sacrifice. Exposure to crude urine and ultrafiltrated urine preparation (<5000 Da) induced significant Fos expression, which is correlated with cellular activity, in the mitral/tufted cell layer of the ac...

journal_title：Biochemical and biophysical research communications

authors： Tsujikawa K,Kashiwayanagi M

更新日期：1999-06-24 00:00:00

abstract：:We have examined the steady-state levels of intermediate filament mRNA in amyotrophic lateral sclerosis using the RNAse protection assay (NFL, NFM, NFH; corrected against GAPDH) or by PCR (peripherin, alpha-internexin, nestin, and vimentin; corrected against beta-actin). Significant elevations of NFL and peripherin mR...

journal_title：Biochemical and biophysical research communications

authors： Strong MJ,Leystra-Lantz C,Ge WW

更新日期：2004-04-02 00:00:00

abstract：:To investigate the identity determinants of E. coli threonine tRNA, various transcripts were prepared by in vitro transcription system with T7 RNA polymerase. Substitutions of the anticodon second letter G35 and the third letter U36 to other nucleotides led to a remarkable decrease of threonine charging activity. Char...

journal_title：Biochemical and biophysical research communications

authors： Hasegawa T,Miyano M,Himeno H,Sano Y,Kimura K,Shimizu M

更新日期：1992-04-15 00:00:00

abstract：:IL-6 is a growth and survival factor for myeloma cells, although the mechanism by which it induces myeloma cell proliferation through gene expression is largely unknown. Microarray analysis showed that some B-cell lymphoma-associated oncogenes such as Bcl6, which is absent in normal plasma cells, were upregulated by I...

journal_title：Biochemical and biophysical research communications

authors： Tsuyama N,Danjoh I,Otsuyama K,Obata M,Tahara H,Ohta T,Ishikawa H

更新日期：2005-11-11 00:00:00

abstract：:Tamoxifen (TAM), an anti-estrogen compound, is widely used for chemotherapy of breast cancer, although the molecular mechanisms underlying TAM cytotoxicity are obscure. Here, we show that TAM dramatically caused degradation of vimentin (VIM) in human skin fibroblasts, in a time and dose dependent manner. Addition of c...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto M,Inoue S,Ogawa S,Conrad C,Muramatsu M,Shackelford D,Masliah E

更新日期：1998-06-18 00:00:00

abstract：:Human adipose-derived mesenchymal stem cells (hASCs) are attractive cell source for skin tissue engineering. The aim of this study was to investigate the effects of low-level light therapy (LLLT) on transplanted cluster hASC in a skin wound animal model. The hASCs were cultured in monolayer or clusters. The LLLT, hASC...

journal_title：Biochemical and biophysical research communications

authors： Park IS,Chung PS,Ahn JC

更新日期：2015-07-03 00:00:00

abstract：:Antibodies raised against deoxyadenylate and deoxycytidylate were found to react with double stranded DNA as assessed by highly sensitive avidin-biotin microELISA. The binding was specific as it was completely inhibited by the homologous hapten. The antibodies did not react with tRNA and rRNA. These antibodies were al...

journal_title：Biochemical and biophysical research communications

authors： Vaishnav YN,Antony A

更新日期：1988-07-15 00:00:00

abstract：:The ontogeny of T-Kininogen expression in the rat liver was examined. Levels approximately 6 fold higher than seen in the adult liver are present during the perinatal period. Elevated levels are also seen in the maternal liver, beginning 5 days prior to parturition. The timing of induction in the fetal and maternal li...

journal_title：Biochemical and biophysical research communications

authors： Mann EA,Lingrel JB

更新日期：1991-01-31 00:00:00

abstract：:Gastrin heptadecapeptides (gastrins I and II which differ in the presence of sulfate on the tyrosine of the latter) have been purified and sequenced from several mammalian species including pig, dog, cat, sheep, cow, human and rat. A 34 amino acid precursor ("big" gastrin), generally accounting for only 5% of total ga...

journal_title：Biochemical and biophysical research communications

authors： Shinomura Y,Eng J,Yalow RS

更新日期：1987-02-27 00:00:00

abstract：:Information about histone sequences and histone gene organization from invertebrate chordates is completely lacking. A genomic clone containing linked H3 and H4 histone genes from the urochordate Styela plicata was analyzed. The nucleotide sequence indicates that the two genes are transcribed in opposite directions an...

journal_title：Biochemical and biophysical research communications

authors： Ishaq AI,Rizvi SB,Wells DE,Tomlinson CR

更新日期：1993-07-30 00:00:00

abstract：:The peptide deformylase in bacteria is involved in removal of N-formyl group from newly synthesized proteins. The gene encoding this enzyme from Mycobacterium tuberculosis was cloned and expressed in Escherichia coli. The enzyme activity of the recombinant protein (mPDF) was insensitive to modulation by common monoval...

journal_title：Biochemical and biophysical research communications

authors： Saxena R,Chakraborti PK

更新日期：2005-07-01 00:00:00

abstract：:Tau plays important roles in the assembly and stabilization of the microtubule structure to facilitate axonal transport in mammalian brain. The intracellular tau aggregates to form paired helical filaments leading to neurodegenerative disorders, collectively called tauopathies. In our previous report, we established a...

journal_title：Biochemical and biophysical research communications

authors： Wu BK,Yuan RY,Chang YP,Lien HW,Chen TS,Chien HC,Tong TS,Tsai HP,Fang CL,Liao YF,Chang CC,Chen RP,Huang CJ

更新日期：2016-08-19 00:00:00

abstract：:Recently, two reports [R. E. Davis et al. (1997) Proc. Natl. Acad. Sci. USA 94, 4564-4569 and E. Fahy et al. (1997) Nucleic Acids Res. 25, 3102-3109] described a series of heteroplasmic mitochondrial DNA (mtDNA) mutations in the genes encoding two cytochrome c oxidase subunits (CO1 and CO2) which segregated in higher ...

journal_title：Biochemical and biophysical research communications

authors： Davis JN 2nd,Parker WD Jr

更新日期：1998-03-27 00:00:00

abstract：:The mechanism by which lithium (Li(+)) inhibits the protein kinase glycogen synthase kinase-3 (GSK-3) is unknown. Here, we demonstrate that Li(+) is a competitive inhibitor of GSK-3 with respect to magnesium (Mg(2+)), but not to substrate or ATP. This mode of inhibition is conserved between mammalian and Dictyostelium...

journal_title：Biochemical and biophysical research communications

authors： Ryves WJ,Harwood AJ

更新日期：2001-01-26 00:00:00

abstract：:Due to their immune stimulating and apoptosis inducing properties, ligands of the TNF family attract increasing interest as therapeutic proteins. A general limitation of in vivo applications of recombinant soluble TNF ligands is their notoriously rapid clearance from circulation. To improve the serum half life of the ...

journal_title：Biochemical and biophysical research communications

authors： Müller N,Schneider B,Pfizenmaier K,Wajant H

更新日期：2010-06-11 00:00:00

abstract：:The family of peptidoglycan recognition proteins (PGRPs) is conserved from insects to mammals. Recently, Drosophila PGRP-SC1B was demonstrated to be an N-acetylmuramoyl-L-alanine amidase (NAMLAA), an enzyme that cleaves the lactylamide bond between muramic acid and the peptide chain in peptidoglycan (PGN). We now show...

journal_title：Biochemical and biophysical research communications

authors： Gelius E,Persson C,Karlsson J,Steiner H

更新日期：2003-07-11 00:00:00

abstract：:The (1)H NMR spectrum of the perchloric acid extract of carp seminal plasma was heavily congested. It is demonstrated that proton-detected C,H chemical shift correlation spectroscopy (HSQC, HSQC-TOCSY) allows an unequivocal identification of proline, glutamate, taurine, and methionine sulfoxide, although several key p...

journal_title：Biochemical and biophysical research communications

authors： Kalic M,Lauterwein J,Büsselmann G,Kamp G

更新日期：2000-03-05 00:00:00

abstract：:Autophagy is a tightly regulated self-digestion system. As in other cell types, autophagy plays an essential role in the homeostasis of pancreatic beta cells. However, the mechanisms involved in the deterioration of beta cell function caused by autophagic failure have not yet been fully elucidated. To gain insight int...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto E,Uchida T,Abe H,Taka H,Fujimura T,Komiya K,Hara A,Ogihara T,Fujitani Y,Ueno T,Takeda S,Watada H

更新日期：2014-10-10 00:00:00

abstract：:miRNAs are approximately 21nt non-coding RNAs and play important roles in plant development and response to stress. Symbiotic nitrogen fixation (SNF) is agronomically important for reducing the need of nitrogen fertilizers. The soybean root nodule is the place where SNF takes place. To identify miRNAs that are possibl...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Li P,Cao X,Wang X,Zhang A,Li X

更新日期：2009-01-23 00:00:00

abstract：:Iron is required in all organisms for crucial functions, as a number of proteins need iron for activity. Mutations of the genes encoding proteins involved in iron uptake, transport, and utilization result in various human disorders or animal models with very different clinical presentations and organ involvement. Howe...

journal_title：Biochemical and biophysical research communications

authors： Rötig A,Chantrel-Groussard K,Munnich A,Rustin P

更新日期：2001-03-02 00:00:00

abstract：:Lafora disease, a progressive myoclonus epilepsy, is an autosomal recessive disease caused in approximately 80% of cases by mutation of the EPM2A gene, which encodes a dual specificity protein phosphatase called laforin. In addition to its phosphatase domain, laforin contains an N-terminal carbohydrate-binding domain ...

journal_title：Biochemical and biophysical research communications

authors： Wang W,Roach PJ

更新日期：2004-12-17 00:00:00

abstract：:The DNA-directed self-assembly of surface-bound layers of gold nanoparticles offers a broad range of applications in biomedical analyses as well as in materials science. We here describe a new concept for the assembly of substrate-bound nanoparticle monolayers which employs bifunctional nanoparticles as building block...

journal_title：Biochemical and biophysical research communications

authors： Niemeyer CM,Ceyhan B,Noyong M,Simon U

更新日期：2003-11-28 00:00:00

abstract：:Apolipoprotein E (apoE), a protein mainly involved in lipid metabolism, is associated with several neurodegenerative disorders including Alzheimer's disease. Despite numerous attempts to elucidate apoE gene regulation in the brain, the exact mechanism is still uncovered. The mechanism of apoE gene regulation in the br...

journal_title：Biochemical and biophysical research communications

authors： Roman C,Fuior EV,Trusca VG,Kardassis D,Simionescu M,Gafencu AV

更新日期：2015-12-04 00:00:00

abstract：:Vaccination evoking immunity in susceptible individuals has become the most effective solution to combat infectious diseases. The surface antigen of hepatitis B virus (HBsAg) is a mandatory vaccine for children in China. Herein, we designed an antimicrobial protein consisting of an antimicrobial peptide Thanatin at th...

journal_title：Biochemical and biophysical research communications

authors： Fan X,Xu W,Gao W,Xiao H,Wu G

更新日期：2021-01-01 00:00:00

abstract：:The solubilized [3H]ryanodine receptor from cardiac sarcoplasmic reticulum was centrifuged through linear sucrose gradients. A single peak of radioactivity with apparent sedimentation coefficient of approximately 30S specifically comigrated with a high molecular weight protein of apparent relative molecular mass appro...

journal_title：Biochemical and biophysical research communications

authors： Lai FA,Anderson K,Rousseau E,Liu QY,Meissner G

更新日期：1988-02-29 00:00:00

abstract：:Amphotericin B (AmB) is a potent antifungal agent used to treat patients with systemic mycoses. The cytotoxicity of AmB is related to its binding to membrane sterols and its clinical usefulness is based on its greater affinity to ergosterol, the fungal sterol, compared to the mammalian cell sterol, cholesterol (1-3). ...

journal_title：Biochemical and biophysical research communications

authors： Gruda I,Gauthier E,Elberg S,Brajtburg J,Medoff G

更新日期：1988-08-15 00:00:00

abstract：:Plant innate immunity varies with age and plant developmental stages. Recently, we reported that Arabidopsis thaliana microRNA miR172b regulates FLS2 transcription through two transcription factors: TARGET OF EAT1 (TOE1) and TOE2. Although the flg22-triggered immune responses were investigated in 2-d-old or even young...

journal_title：Biochemical and biophysical research communications

authors： Zou Y,Wang S,Lu D

更新日期：2020-10-22 00:00:00