Coffee diterpenes prevent benzo[a]pyrene genotoxicity in rat and human culture systems.

Abstract:

:The coffee-specific diterpenes cafestol and kahweol (C+K) have been identified as two important chemoprotective agents in coffee. In the present study, the potential preventive effects of C+K against the genotoxicity of B[a]P were investigated in rat primary hepatocytes and in human bronchial Beas-2B cells. Several independent mechanisms were identified and their respective contribution to the overall protective effects was determined. A marked dose-dependent inhibition by C+K of B[a]P DNA-binding was found in cells of both origins. However, data showed that the significant induction by C+K of the detoxifying enzyme GST-Yp subunit is the key mechanism of protection against B[a]P DNA-binding in rat liver. In contrast, the phase I-mediated mechanism where C+K produce an inhibition of CYP 1A1 induction by B[a]P is of key significance for the C+K protection in human Beas-2B cells. Moreover, this effect suggests a novel mechanism of chemoprotection by the coffee diterpenes cafestol and kahweol.

authors

Cavin C,Bezencon C,Guignard G,Schilter B

doi

10.1016/s0006-291x(03)00994-x

subject

Has Abstract

pub_date

2003-06-27 00:00:00

pages

488-95

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X0300994X

journal_volume

306

pub_type

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