Recombinant human interferon sensitizes resistant myeloid leukemic cells to induction of terminal differentiation.

Abstract:

:Recombinant human leukocyte interferon (IFN-alpha A) inhibits growth of the human promyelocytic leukemic cell line HL-60 without inducing these cells to differentiate terminally. When IFN-alpha A is combined with agents capable of inducing differentiation in HL-60 cells, such as 12-O-tetradecanoyl-phorbol-13-acetate (TPA), cis or trans retinoic acid (RA) or dimethylsulfoxide (DMSO), growth suppression and induction of differentiation are dramatically increased. By growing HL-60 cells in increasing concentrations of TPA, RA, or DMSO, a series of sublines have been developed which are resistant to the usual growth inhibition and induction of differentiation seen when wild type HL-60 cells are exposed to these agents. Treatment of these resistant HL-60 cells with the combination of IFN-alpha A and the appropriate inducer results, however, in a synergistic suppression in cell growth and a concomitant induction of terminal differentiation. The ability of interferon to interact synergistically with agents which promote leukemic cell maturation may represents a novel means of reducing resistant leukemic cell populations.

authors

Grant S,Bhalla K,Weinstein B,Pestka S,Mileno MD,Fisher PB

doi

10.1016/0006-291x(85)90428-0

subject

Has Abstract

pub_date

1985-07-16 00:00:00

pages

379-88

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(85)90428-0

journal_volume

130

pub_type

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