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Human neutrophils store type II 14-kDa phospholipase A2 in granules and secrete active enzyme in response to soluble stimuli.

Abstract：

:Although "secretory" type II 14-kDa phospholipase A2 (sPLA2) activity has been described in neutrophils, direct evidence of enzyme secretion has been elusive. We have used immunogold electron microscopy with polyclonal and monoclonal antibodies to sPLA2 to demonstrate localization of the enzyme to granules of resting human neutrophils and translocation to phagolysosomes. Soluble stimuli such as calcium ionophore A23187 stimulate loss of cell-associated enzymatic activity. Supernatant fluids from stimulated neutrophils lack measurable PLA2 but contain proteases which inactivate exogenous sPLA2. The use of alpha-1-antitrypsin as a protease inhibitor permitted this first demonstration of secretion of PLA2 activity from stimulated human neutrophils.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Rosenthal MD,Gordon MN,Buescher ES,Slusser JH,Harris LK,Franson RC

doi

10.1006/bbrc.1995.1388

subject

Has Abstract

pub_date

1995-03-17 00:00:00

pages

650-6

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)71388-5

journal_volume

208

pub_type

杂志文章

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