Characterization of the glucose transporter from rat brain synaptosomes.

abstract：:We have isolated and characterized the cDNA encoding a novel protein designated DJ-1. DJ-1, sharing no significant homology with the sequences so far reported, did not show transactivation activity in the Gal4 recombinant system, but transformed mouse NIH3T3 cells by itself. Furthermore, DJ-1 showed a cooperative tran...

journal_title：Biochemical and biophysical research communications

authors： Nagakubo D,Taira T,Kitaura H,Ikeda M,Tamai K,Iguchi-Ariga SM,Ariga H

更新日期：1997-02-13 00:00:00

abstract：:The aim of this study was to investigate the response to and the physiological consequences of copper-mediated cross-linking of S100A2 and S100A4, two members of the S100 family of EF-hand calcium-binding proteins. As demonstrated by electrophoresis and mass spectrometry techniques S100A2 and S100A4 show formation of ...

journal_title：Biochemical and biophysical research communications

authors： Haase-Kohn C,Wolf S,Lenk J,Pietzsch J

更新日期：2011-09-30 00:00:00

abstract：:Botulinum neurotoxins (BoNTs) are produced as progenitor toxin complexes (PTCs) by Clostridium botulinum. The PTCs are composed of BoNT and non-toxic neurotoxin-associated proteins (NAPs), which serve to protect and deliver BoNT through the gastrointestinal tract in food borne botulism. HA33 is a key NAP component tha...

journal_title：Biochemical and biophysical research communications

authors： Lee K,Lam KH,Kruel AM,Perry K,Rummel A,Jin R

更新日期：2014-04-04 00:00:00

abstract：:Hepatocyte growth factor/scatter factor (HGF) is a multifunctional growth factor that is linked to the initiation and/or progression of numerous malignancies. HGF also alters cancer cell responses to DNA damaging cytotoxic agents. Many cell responses to Met activation require alterations in metabolic activity but how ...

journal_title：Biochemical and biophysical research communications

authors： Xia S,Laterra J

更新日期：2006-07-14 00:00:00

abstract：:The placenta releases syncytiotrophoblast-derived extracellular vesicles (STB-EV) into the maternal circulation throughout gestation. STB-EV dependent signalling is believed to contribute to the widespread maternal adaptive physiological changes seen in pregnancy. Transfer RNA (tRNA) halves have been identified in ves...

journal_title：Biochemical and biophysical research communications

authors： Cooke WR,Cribbs A,Zhang W,Kandzija N,Motta-Mejia C,Dombi E,Ri R,Cerdeira AS,Redman C,Vatish M

更新日期：2019-10-08 00:00:00

abstract：:Peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1) modulates phospho-signaling by catalyzing rotation of the bond between a phosphorylated serine or threonine before proline in proteins. As depletion of PIN1 increased inflammatory protein expression in cultured endothelial cells treated with bacterial endot...

journal_title：Biochemical and biophysical research communications

authors： Liu T,Schneider RA,Lee NY,Hoyt DG

更新日期：2014-09-26 00:00:00

abstract：:Hepatocytes from human bone marrow-derived mesenchymal stem cells (hBM-MSCs) are expected to be a useful source for cell transplantation. However, relatively low efficiency and repeatability of hepatic differentiation of human BM-MSCs remains an obstacle for clinical translation. Hepatocyte nuclear factor 4 alpha (HNF...

journal_title：Biochemical and biophysical research communications

authors： Hu X,Xie P,Li W,Li Z,Shan H

更新日期：2016-09-16 00:00:00

abstract：:Polymerization of actin induced by activation of platelets was investigated using deoxyribonuclease I inhibition assay. When platelets were activated with ADP or 5-hydroxytryptamine, actin was polymerized quickly followed by rapid depolymerization to the initial level. Reactivation with the same agonist, however, did ...

journal_title：Biochemical and biophysical research communications

authors： Imada T,Kikuchi T,Shimada H,Inada Y,Saito Y

更新日期：1984-05-16 00:00:00

abstract：:Embryo development proceeds under strict temporal control and an embryonic molecular clock (EC), evidenced by cyclic gene expression, is operating during somite formation and limb development, providing temporal information to precursor cells. In somite precursor cells, EC gene expression and periodicity depends on Re...

journal_title：Biochemical and biophysical research communications

authors： Sheeba CJ,Palmeirim I,Andrade RP

更新日期：2012-07-13 00:00:00

abstract：:The bright bioluminescence of copepod Metridia longa is conditioned by a small secreted coelenterazine-dependent luciferase (MLuc). To date, three isoforms of MLuc differing in length, sequences, and some properties were cloned and successfully applied as high sensitive bioluminescent reporters. In this work, we repor...

journal_title：Biochemical and biophysical research communications

authors： Larionova MD,Markova SV,Vysotski ES

更新日期：2017-01-29 00:00:00

abstract：:FOXK2, which belongs to the fork head DNA binding protein family, has been shown to play a critical role in tumorigenesis. Here, we detected FOXK2 expression and its clinical significance in colorectal cancer, which has not been fully investigated before. Results from public database and our cohort indicated that FOXK...

journal_title：Biochemical and biophysical research communications

authors： Qian Y,Xia S,Feng Z

更新日期：2017-01-29 00:00:00

abstract：:Adsorption of phage T4 to its outer membrane receptor (the lipopolysaccharide) triggers a transient depolarization of the cytoplasmic membrane which is prevented upon addition of EGTA, suggesting that calcium is necessary for the transmission of the signal between the two membranes. Using the fluorescent indicator QUI...

journal_title：Biochemical and biophysical research communications

authors： Boulanger P,Labedan B,Letellier L

更新日期：1985-09-16 00:00:00

abstract：:An endonuclease that specifically removes 8-hydroxyguanine (oh8Gua) from DNA has been isolated from Escherichia coli. As the amount of oh8Gua produced in DNA of X-ray-irradiated mice is known to decrease with time after irradiation, an attempt was made to find a similar activity in human polymorphonuclear neutrophils ...

journal_title：Biochemical and biophysical research communications

authors： Chung MH,Kim HS,Ohtsuka E,Kasai H,Yamamoto F,Nishimura S

更新日期：1991-08-15 00:00:00

abstract：:The regulatory systems of endogenous endothelin-1 (ET-1) production from intact tissues and the effects of produced ET-1 on vascular tonus by a closed circuit perfusion system of rat mesenteric artery were investigated. It was demonstrated that ET-1 is released from intact mesenteric arterial beds from Wistar rats bot...

journal_title：Biochemical and biophysical research communications

authors： Tomobe Y,Yanagisawa M,Fujimori A,Masaki T,Goto K

更新日期：1993-03-15 00:00:00

abstract：:One of the mechanisms underlying the induction of human inducible nitric oxide synthase (hiNOS) by cytokines is transcriptional regulation. However, previous reports suggest that in human cells, the cytokine activation of the hiNOS expression is accompanied by a drastic increase in cellular mRNA and protein content, b...

journal_title：Biochemical and biophysical research communications

authors： Nunokawa Y,Oikawa S,Tanaka S

更新日期：1997-04-17 00:00:00

abstract：:Neurotensin (NT) is now classified as a brain-gut peptide in the central nervous system and gastrointestinal tract. In the present study, we characterized the NT receptors on the rat liver plasma membranes. The specific binding of [3H]NT was time dependent, reversible, and saturable. Scatchard analysis of the specific...

journal_title：Biochemical and biophysical research communications

authors： Muraki K,Nishi Y,Arai M,Kubo N,Ueda K,Shikata H,Nakata Y,Segawa T,Yanaihara N,Yajima H

更新日期：1987-06-30 00:00:00

abstract：:Calcium is found a strong stimulator of sulfite reduction from hydrogen. A coupling protein of molecular weight 65,000 can be isolated from Desulfovibrio gigas. It functions in a reconstituted electron transfer chain between hydrogenase and sulfite reductase. Its N-terminal sequence shows high homologies with calcium ...

journal_title：Biochemical and biophysical research communications

authors： Chen L,Liu MY,Le Gall J

更新日期：1991-10-15 00:00:00

abstract：:The main protein of enriched and purified amyloid from Octodon degus pancreatic islets was identified as insulin. The material was reduced and alkylated and the A- and the B-chain were separated by reversed phase chromatography and subjected to Edman degradation and amino acid analysis. It was shown that the A-chain c...

journal_title：Biochemical and biophysical research communications

authors： Hellman U,Wernstedt C,Westermark P,O'Brien TD,Rathbun WB,Johnson KH

更新日期：1990-06-15 00:00:00

abstract：:In mammals dietary ferric iron is reduced to ferrous iron for more efficient absorption by the intestine. Analysis of a pig duodenal membrane fraction revealed two NADH-dependent ferric reductase activities, one associated with a b-type cytochrome and the other not. Purification and characterization of the non-cytochr...

journal_title：Biochemical and biophysical research communications

authors： Lee PL,Halloran C,Cross AR,Beutler E

更新日期：2000-05-19 00:00:00

abstract：:Alternative splicing is a major mechanism regulating pattern of gene expression through the production of multiple mRNAs from a single gene transcript. Any misregulation can cause various human diseases and also have severe effects on embryogenesis. SRSF1 is one of the critical factors regulating alternative splicing ...

journal_title：Biochemical and biophysical research communications

authors： Lee SH,Lee HK,Kim C,Kim YK,Ismail T,Jeong Y,Park K,Park JW,Kwon OS,Kang BS,Lee DS,Park MJ,Park DS,Lee HS

更新日期：2016-09-02 00:00:00

abstract：:Endothelin-like immunoreactivity (-LI) was detected in the kidney, spleen, skeletal muscle, lung and in plasma of the pig. The highest tissue levels were found in the lung (1.5 +/- 0.07 pmol/g) and the lowest in the muscle (0.08 +/- 0.02 pmol/g). I.v. infusion of endothelin (20 pmol/kg/min for 20 min) increased plasma...

journal_title：Biochemical and biophysical research communications

authors： Pernow J,Hemsén A,Lundberg JM

更新日期：1989-06-15 00:00:00

abstract：:Four conserved residues of Clostridium thermocellum endoglucanase CelC were replaced by site-directed mutagenesis. Proteins mutated in His-90, Asn-139 and Glu-140 showed strongly reduced activity, in agreement with predictions of sequence alignments. Mutations in Glu-140 did not result in any detectable change in Km, ...

journal_title：Biochemical and biophysical research communications

authors： Navas J,Béguin P

更新日期：1992-12-15 00:00:00

abstract：:The compounds [Pt(IV)(dach)(9-methylguanine)2X2]2+ (X = Cl, OH) have been prepared and structurally characterized. Their existence shows that it is possible to accommodate two purine bases (in a cis configuration) and four other ligands around a Pt(IV) atom. The geometries of these complexes have very different orient...

journal_title：Biochemical and biophysical research communications

authors： Choi HK,Huang SK,Bau R

更新日期：1988-11-15 00:00:00

abstract：:Neuromedin K and neuromedin L are novel mammalian tachykinins isolated from porcine spinal cord. We have developed a highly sensitive radioimmunoassay for neuromedin K. Since the radioimmunoassay for neuromedin K has significant crossreactivity with neuromedin L and substance P, we can simultaneously determine the tis...

journal_title：Biochemical and biophysical research communications

authors： Minamino N,Masuda H,Kangawa K,Matsuo H

更新日期：1984-11-14 00:00:00

abstract：:Vascular calcification increases the risk of developing cardiovascular disease, and it is closely associated with metabolic disorders such as diabetes mellitus and non-alcoholic fatty liver disease. We investigated whether the activators of AMP-activated protein kinase (AMPK), metformin, resveratrol, and exendin-4, im...

journal_title：Biochemical and biophysical research communications

authors： Lee J,Hong SW,Kim MJ,Kwon H,Park SE,Rhee EJ,Lee WY

更新日期：2020-09-17 00:00:00

abstract：:Tuberous sclerosis complex 2 (TSC2) is a tumor-suppressor protein that is partially regulated by insulin, energy, oxygen, and growth factors. Mutations in the TSC2 gene and loss of TSC2 promote cell growth by the mammalian target of rapamycin complex 1 (mTORC1) activation. Furthermore, S-adenosylmethionine (SAM) senso...

journal_title：Biochemical and biophysical research communications

authors： Gen S,Matsumoto Y,Suzuki T,Inoue J,Yamamoto Y

更新日期：2021-01-19 00:00:00

abstract：:Action potentials of myotubes in culture prepared from 18-19 day -old mouse embryos have a contractile activity and action potentials that are followed by a long lasting after hyperpolarization (ahp) which is blocked by apamin. Myotubes prepared from embryos of mice with muscular dysgenesis (mdg/mdg) did not contract ...

journal_title：Biochemical and biophysical research communications

authors： Romey G,Rieger F,Renaud JF,Pinçon-Raymond M,Lazdunski M

更新日期：1986-05-14 00:00:00

abstract：:Polyacrylamide gel electrophoresis and isoelectrofocusing followed by immunoblotting technique with an anti-human retinol-binding protein (RBP) serum were used to study holo-RBP and apo-RBP in human plasma. Three observations were made the technique allowed for the first time to directly and quantitatively analyse hol...

journal_title：Biochemical and biophysical research communications

authors： Siegenthaler G,Saurat JH

更新日期：1987-03-13 00:00:00

abstract：:Reactive oxygen species are known to induce strand breaks and/or base modifications in DNA. DNA strand breaks are associated with many pathologies and programmed cell death. We have examined the ability of the polyamines and their analogues to protect phi X-174 plasmid DNA from strand breakage induced by a oxygen-radi...

journal_title：Biochemical and biophysical research communications

authors： Ha HC,Yager JD,Woster PA,Casero RA Jr

更新日期：1998-03-06 00:00:00

abstract：:Isovalerylcarnitine, a product of the catabolism of L-leucine, is a potent activator of rat calpains isolated from erythrocytes, kidney, liver, skeletal and heart muscle. Only calpains II, but not calpains I, are activated by IVC, with the only exception of rat erythrocyte calpain I, the only species present in these ...

journal_title：Biochemical and biophysical research communications

authors： Pontremoli S,Melloni E,Viotti PL,Michetti M,Di Lisa F,Siliprandi N

更新日期：1990-02-28 00:00:00