Reversible beta-pleated sheet formation of a phosphorylated synthetic tau peptide.

abstract：:In mammals, pigments are made by melanocytes within a specialized organelle, the melanosome. Mature, pigment-laden melanosomes are then transferred to keratinocytes to drive the visible pigmentation of the animal's hair and skin. The dilute suppressor (dsu) locus encodes an extragenic suppressor of the pigmentation de...

journal_title：Biochemical and biophysical research communications

authors： Wu XS,Martina JA,Hammer JA 3rd

更新日期：2012-09-21 00:00:00

abstract：:The distribution of SQSC1 mRNA in tissues of squid Loligo bleekeri was studied by the blot hybridization method. The complete cDNA for the coding region of SQSC1, the invertebrate putative sodium channel, was prepared from squid optic lobe (Sato and Matsumoto, Biochem. Biophys. Res. Comm. 186, 61-68, 1992). Transcript...

journal_title：Biochemical and biophysical research communications

authors： Sato C,Hirota K,Matsumoto G

更新日期：1995-01-26 00:00:00

abstract：:Thioredoxin-interacting protein (TXNIP) has multiple disease-associated functions including inducing oxidative stress by inhibiting the anti-oxidant and thiol reducing activity of thioredoxin (TRX), reducing cellular glucose transport, and is a component of the activated inflammasome complex. Increased expression of T...

journal_title：Biochemical and biophysical research communications

authors： Buyandelger U,Walker DG,Taguchi H,Yanagisawa D,Tooyama I

更新日期：2020-11-19 00:00:00

abstract：:Cultured endothelial cells release a potent vasoconstrictor peptide, endothelin. Cumulative addition of synthetic endothelin to isolated rabbit aortic rings elicited a concentration-dependent increase in contractile tension which was endothelium-independent. In cultured rabbit vascular smooth muscle cells loaded with ...

journal_title：Biochemical and biophysical research communications

authors： Marsden PA,Danthuluri NR,Brenner BM,Ballermann BJ,Brock TA

更新日期：1989-01-16 00:00:00

abstract：:Human erythrocytes express a p57 membrane serine proteinase which cleaves C3, the third component of complement. Amino acid analysis of the first 20 N-terminal residues of the purified p57 proteinase demonstrated 100% homology with residues 910-929 of erythrocyte ankyrin, a sequence localized in its Mr = 62 kDa fragme...

journal_title：Biochemical and biophysical research communications

authors： Hermann J,Barel M,Frade R

更新日期：1994-10-28 00:00:00

abstract：:2-Hydroxyheptanal (2-HH) is one of the reactive aldehyde species generated during the peroxidation of n-6 polyunsaturated fatty acids, such as linoleic and arachidonic acids. Analogous to the Maillard reaction of reducing sugars, 2-HH readily reacts with lysine epsilon-amino groups. In the present study, to define the...

journal_title：Biochemical and biophysical research communications

authors： Itakura K,Furuhata A,Shibata N,Kobayashi M,Uchida K

更新日期：2003-08-29 00:00:00

abstract：:The human amyloid beta protein (BP) is a major constituent of the amyloid deposited in the brain of patients with Alzheimer's disease and is derived from a larger precursor protein (BPP). In human three alternatively-spliced forms of BPP mRNA were found and two of them were shown to encode a protease inhibitory activi...

journal_title：Biochemical and biophysical research communications

authors： Yamada T,Sasaki H,Dohura K,Goto I,Sakaki Y

更新日期：1989-02-15 00:00:00

abstract：:GALIG, an internal gene to the human galectin-3 gene, encodes two distinct proteins, Mitogaligin and Cytogaligin through translation of a unique mRNA in two overlapping alternative reading frames. When overexpressed GALIG induces apoptosis. In cultured cells, Mitogaligin destabilizes mitochondria membranes through int...

journal_title：Biochemical and biophysical research communications

authors： El Haddad S,Serrano A,Normand T,Robin C,Dubois M,Brulé-Morabito F,Mollet L,Charpentier S,Legrand A

更新日期：2018-01-01 00:00:00

abstract：:Membranes of HL-60 cells were shown to possess saturable binding sites for [3H]inositol(1,3,4,5)tetrakisphosphate, with nanomolar affinity (KD = 90 nM) and a density of 250 fmol/mg protein. The specificity of the binding sites for Ins(1,3,4,5)P4 was assessed by competition studies utilising a variety of inositol polyp...

journal_title：Biochemical and biophysical research communications

authors： Bradford PG,Irvine RF

更新日期：1987-12-16 00:00:00

abstract：:The endothelin system consists of three ligands (ET-1, ET-2 and ET-3) and at least two receptors (ETA and ETB). In mice ET-2 counterpart is a peptide originally called "vasoactive intestinal contractor" (VIC) for this reason, this peptide is frequently named ET-2/VIC. In intestinal villi, fibroblasts-like cells expres...

journal_title：Biochemical and biophysical research communications

authors： Bianchi M,Adur J,Takizawa S,Saida K,Casco VH

更新日期：2012-01-27 00:00:00

abstract：:Molecular mechanisms relating interferon-alpha (IFN-alpha) to brain damage have recently been identified in a microarray analysis of cerebrospinal fluid lymphocytes from patients with Aicardi-Goutières Syndrome (AGS). These findings demonstrate that the inhibition of angiogenesis and the activation of neurotoxic lymph...

journal_title：Biochemical and biophysical research communications

authors： Pulliero A,Marengo B,Longobardi M,Fazzi E,Orcesi S,Olivieri I,Cereda C,Domenicotti C,Balottin U,Izzotti A

更新日期：2013-01-18 00:00:00

abstract：BACKGROUND:Research has indicated that Herba Patriniae can suppress the growth of Several kinds of tumor cells in vitro and in vivo, thus displaying favorable antitumor activity. However, research regarding the effect of saponins of Patrinia villosa against CRC cell has not been reported. In the current study, We have ...

journal_title：Biochemical and biophysical research communications

authors： Xia L,Zhang B,Yan Q,Ruan S

更新日期：2018-09-10 00:00:00

abstract：:The syndrome of generalized epilepsy with febrile seizures plus type 1 (GEFS+) has been associated to the gene SCN1B coding for the sodium channel beta1 subunit (Wallace, R. H. et al. (1998) Nature Genetics 19, 366-370). In patients, a mutation of the cysteine 121 to trpyptophane (C121W) would cause a lack of modulato...

journal_title：Biochemical and biophysical research communications

authors： Moran O,Conti F

更新日期：2001-03-23 00:00:00

abstract：:Structural determinants of L-[(3)H]nicotine binding to synthetic peptides comprising residues 188-207 of nicotinic acetylcholine receptor alpha subunits were invesitigated by equilibrium binding analysis. Two binding components were detected, one of low affinity (K(d) approximately 1.5 microM) that did not differ sign...

journal_title：Biochemical and biophysical research communications

authors： Lentz TL

更新日期：2000-02-16 00:00:00

abstract：:Peptides containing phosphonate based non-hydrolyzable phosphotyrosyl (pTyr) mimetics previously have been shown to be competitive inhibitors of protein-tyrosine phosphatases (PTPs). These agents suffer from low cellular penetration which is partially attributable to ionization of the phosphonate group at physiologica...

journal_title：Biochemical and biophysical research communications

authors： Kole HK,Akamatsu M,Ye B,Yan X,Barford D,Roller PP,Burke TR Jr

更新日期：1995-04-26 00:00:00

abstract：:Methiocarb, an aromatic-alkyl sulfide insecticide was enzymatically oxidized into its sulfoxide by microsomes from soybean cotyledons. No further oxidation into sulfone was detected. Distribution of the sulfoxidase activity was studied in soybean seedlings and found maximal in cotyledons. Subcellular fractionation of ...

journal_title：Biochemical and biophysical research communications

authors： Blee E,Durst F

更新日期：1986-03-28 00:00:00

abstract：:The interaction between the receptor (Rc) for atrial natriuretic peptide (ANP) and the effector enzyme particulate guanylate cyclase (GC) has been studied by radiation inactivation. Irradiation of bovine lung membranes produced an increase in GC activity at low radiation doses followed by a dose-dependent reduction at...

journal_title：Biochemical and biophysical research communications

authors： Ohuchi S,Hagiwara H,Ishido M,Fujita T,Kume T,Ishigaki I,Hirose S

更新日期：1989-01-31 00:00:00

abstract：:O2-dependent reactions of the ferric and ferrous forms of alpha-hydroxyheme complexed with water-soluble rat heme oxygenase-1 were examined by rapid-scan stopped-flow measurements. Ferric alpha-hydroxyheme reacted with O2 to form ferric verdoheme with an O2-dependent rate constant of 4x10(5) M(-1) s(-1) at pH 7.4 and ...

journal_title：Biochemical and biophysical research communications

authors： Sakamoto H,Takahashi K,Higashimoto Y,Harada S,Palmer G,Noguchi M

更新日期：2005-12-09 00:00:00

abstract：:The purpose of this study was to examine whether mechanical tensile forces affect estrogen regulation of collagen synthesis of anterior cruciate ligament fibroblasts at the mRNA level. Estrogen was studied at three physiologic levels, 10(-11), 10(-10), and 10(-9)M. The results revealed that estrogen alone stimulated T...

journal_title：Biochemical and biophysical research communications

authors： Lee CY,Smith CL,Zhang X,Hsu HC,Wang DY,Luo ZP

更新日期：2004-05-14 00:00:00

abstract：:Type VII collagen (Col7) is the major component of anchoring fibrils and very important for skin integrity. This is emphasized by the Col7 related skin blistering diseases dystrophic epidermolysis bullosa and epidermolysis bullosa acquisita. Structural data that provides insights into the interaction network of Col7 a...

journal_title：Biochemical and biophysical research communications

authors： Wegener H,Leineweber S,Seeger K

更新日期：2013-01-11 00:00:00

abstract：:We investigated the role of Toll-like receptor 4 (TLR4), a major mediator of innate immune responses, on cognitive performance in a type 1 diabetes model (T1D). After administration of streptozotocin, both TLR4 knockout (TLR4 KO) and wild type (WT) diabetic mice displayed metabolic alterations similar to those observe...

journal_title：Biochemical and biophysical research communications

authors： Kawamoto EM,Cutler RG,Rothman SM,Mattson MP,Camandola S

更新日期：2014-01-10 00:00:00

abstract：:S100 proteins are acidic calcium-binding proteins present in high concentration in the brain and at lower concentrations in peripheral tissues. Their function remains to be elucidated in many tissues. In this report we show for the first time that S100 proteins stimulate the bovine photoreceptor membrane guanylate cyc...

journal_title：Biochemical and biophysical research communications

authors： Margulis A,Pozdnyakov N,Sitaramayya A

更新日期：1996-01-05 00:00:00

abstract：:Advanced glycation end products (AGE) are involved in tissue damage and remodeling. This study investigated whether AGE could elicit inflammatory and fibrogenic reactions in fibroblast cell line MRC-5 cells via autocrine production of aldosterone and if nifedipine could block the AGE actions through mineralocorticoid ...

journal_title：Biochemical and biophysical research communications

authors： Matsui T,Takeuchi M,Yamagishi S

更新日期：2010-05-28 00:00:00

abstract：:Mycobacterium tuberculosis (MTB) infection can induce cytotoxicity to the host macrophages, promoting bacterial spread. We here tested the potential effect of oltipraz, a synthetic dithiolethione, in MTB-infected human macrophages. We show that oltipraz significantly inhibited MTB-induced death and apoptosis in human ...

journal_title：Biochemical and biophysical research communications

authors： Sun Q,Shen X,Ma J,Lou H,Zhang Q

更新日期：2020-10-20 00:00:00

abstract：:AHNAK is a giant protein of approximately 700 kDa identified in human neuroblastomas and skin epithelial cells. Recently, we found that AHNAK knock-out (AHNAK(-/-)) mice have a strong resistance to high-fat diet-induced obesity. In this study, we applied (1)H NMR-based metabolomics with multivariate statistical analys...

journal_title：Biochemical and biophysical research communications

authors： Kim IY,Jung J,Jang M,Ahn YG,Shin JH,Choi JW,Sohn MR,Shin SM,Kang DG,Lee HS,Bae YS,Ryu DH,Seong JK,Hwang GS

更新日期：2010-12-17 00:00:00

abstract：:A polymerase chain reaction-generated mouse ACTH-R probe was used to screen a mouse genomic library, and a clone of 13kb containing the entire coding sequence was isolated. The coding sequence shows 84% homology with the human gene at the DNA level and encodes a peptide with 89% homology to the human ACTH-R. This gene...

journal_title：Biochemical and biophysical research communications

authors： Cammas FM,Kapas S,Barker S,Clark AJ

更新日期：1995-07-26 00:00:00

abstract：:Transgenic mice expressing nuclear sterol regulatory element-binding protein-1a under the control of the insulin promoter were generated to determine the role of SREBP-1a in pancreatic beta-cells. Only low expressors could be established, which exhibited mild hyperglycemia, impaired glucose tolerance, and reduced plas...

journal_title：Biochemical and biophysical research communications

authors： Iwasaki Y,Iwasaki H,Yatoh S,Ishikawa M,Kato T,Matsuzaka T,Nakagawa Y,Yahagi N,Kobayashi K,Takahashi A,Suzuki H,Yamada N,Shimano H

更新日期：2009-01-16 00:00:00

abstract：:Evidence exists that the adenosine receptor A(2A)R and the dopamine receptor D(2)R form constitutive heteromers in living cells. Mass spectrometry and pull-down data showed that an arginine-rich domain of the D(2)R third intracellular loop binds via electrostatic interactions to a specific motif of the A(2A)R C-termin...

journal_title：Biochemical and biophysical research communications

authors： Borroto-Escuela DO,Marcellino D,Narvaez M,Flajolet M,Heintz N,Agnati L,Ciruela F,Fuxe K

更新日期：2010-03-26 00:00:00

abstract：:The epithelial-mesenchymal transition (EMT), a key process in the tumor metastatic cascade, is characterized by the loss of cell-cell junctions and cell polarity, as well as the acquisition of migratory and invasive properties. Snail is an EMT-inducer whose expression in several different epithelial cells, e.g., Madin...

journal_title：Biochemical and biophysical research communications

authors： Ozawa M,Kobayashi W

更新日期：2015-03-13 00:00:00

abstract：:The translation terminator Sup35p assembles into self-replicating fibrillar aggregates that are responsible for the [PSI+] prion state. The Q/N-rich N-terminal domain together with the highly charged middle-domain (NM domain) drive the assembly of Sup35p into amyloid fibrils in vitro. NM domains are highly divergent a...

journal_title：Biochemical and biophysical research communications

authors： Kabani M,Melki R

更新日期：2020-08-27 00:00:00