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Interaction of Alpha-synuclein with Cytogaligin, a protein encoded by the proapoptotic gene GALIG.

Abstract：

:GALIG, an internal gene to the human galectin-3 gene, encodes two distinct proteins, Mitogaligin and Cytogaligin through translation of a unique mRNA in two overlapping alternative reading frames. When overexpressed GALIG induces apoptosis. In cultured cells, Mitogaligin destabilizes mitochondria membranes through interaction with cardiolipin. Little is known regarding the role of Cytogaligin. This protein displays multiple subcellular localizations; cytosol, nucleus, and mitochondria. We illustrate here that Cytogaligin is also secreted in the extracellular medium. Cytogaligin is shown to interact with α-Synuclein, the major component of Lewy bodies in Parkinson's disease. Overexpression of Cytogaligin reduces α-Synuclein dimerization raising a possible role in the evolution of α-Synuclein aggregation, a key molecular event underlying the pathogenesis of Parkinson's disease.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

El Haddad S,Serrano A,Normand T,Robin C,Dubois M,Brulé-Morabito F,Mollet L,Charpentier S,Legrand A

doi

10.1016/j.bbrc.2017.11.078

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

787-792

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(17)32256-8

journal_volume

495

pub_type

杂志文章

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