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Protein kinase A accelerates the rate of early stage differentiation of pluripotent stem cells.

Abstract：

:In normal development, the rate of cell differentiation is tightly controlled and critical for normal development and stem cell differentiation. However, the underlying mechanisms regulating the rate of the differentiation are unknown, and manipulation of the rate of the stem cell differentiation is currently difficult. Here we show that activation of protein kinase A (PKA) accelerates the rate of mouse embryonic stem cell (ESC) differentiation through an early loss of ESC pluripotency markers and early appearance of mesodermal and other germ layer cells. The activation of PKA hastened differentiation by increasing the expression of a histone H3 lysine 9 (H3K9) dimethyltransferase, G9a protein, and the level of a negative epigenetic histone mark, H3K9 dimethylation (H3K9me2), in the promoter regions of the pluripotency markers Nanog and Oct4. These results elucidate a novel role of PKA on ESC differentiation and offer an experimental model for controlling the rate of ESC differentiation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Minakawa T,Kanki Y,Nakamura K,Yamashita JK

doi

10.1016/j.bbrc.2019.12.098

subject

Has Abstract

pub_date

2020-03-26 00:00:00

pages

57-63

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(20)30042-5

journal_volume

524

pub_type

杂志文章

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