Tertiary structure prediction of SARS coronavirus helicase.

Abstract:

:SARS coronavirus, SCV, has been recently responsible of a sudden and widespread infection which caused almost 800 victims. The limited amount of SCV protein structural information is partially responsible of the lack of specific drugs against the virus. Coronavirus helicases are very conserved and peculiar proteins which have been proposed as suitable targets for antiviral drugs, such as bananins, which have been recently shown to inhibit the SCV helicase in vitro. Here, the quaternary structure of SCV helicase has been predicted, which will provide a solid foundation for the rational design of other antiviral helicase inhibitors.

authors

Bernini A,Spiga O,Venditti V,Prischi F,Bracci L,Huang J,Tanner JA,Niccolai N

doi

10.1016/j.bbrc.2006.03.069

subject

Has Abstract

pub_date

2006-05-19 00:00:00

pages

1101-4

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)00601-2

journal_volume

343

pub_type

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