Absence of NADH channeling in coupled reaction of mitochondrial malate dehydrogenase and complex I in alamethicin-permeabilized rat liver mitochondria.

abstract：:Ca2+/calmodulin-dependent protein kinases are implicated in regulating the Ca2+ signaling involved in T cell activation and in thymocyte selection. One of the earliest events in signaling through the T cell antigen receptor is activation of the protein tyrosine kinase p56lck. Following T cell activation or signaling t...

journal_title：Biochemical and biophysical research communications

authors： Bland MM,McDonald OB,Carrera AC

更新日期：1994-01-14 00:00:00

abstract：:The yellow locus in Drosophila is involved in both cuticle development and behaviour. However, the function of the encoded protein is unknown. Here we have characterised the sequence and expression pattern of a new Drosophila gene, designated yellow-B, encoding a 453-amino-acid protein that is 57% identical to Yellow....

journal_title：Biochemical and biophysical research communications

authors： Maleszka R,Kucharski R

更新日期：2000-04-21 00:00:00

abstract：:Translation initiation factor 5B (IF5B) is required for initiation of protein synthesis. The solution structure of archaeal IF5B (aIF5B) was analysed by small-angle X-ray scattering (SAXS) and dynamic light scattering (DLS) and was indicated to be in both monomeric and dimeric form. Sedimentation equilibrium (SE) anal...

journal_title：Biochemical and biophysical research communications

authors： Rasmussen LC,Oliveira CL,Byron O,Jensen JM,Pedersen JS,Sperling-Petersen HU,Mortensen KK

更新日期：2011-12-09 00:00:00

abstract：:Heat shock proteins (HSPs) are involved in protein folding, aggregation, transport and/or stabilization by acting as a molecular chaperone, leading to inhibition of apoptosis by both caspase dependent and/or independent pathways. HSPs are overexpressed in a wide range of human cancers and are implicated in tumor cell ...

journal_title：Biochemical and biophysical research communications

authors： Sarkar R,Mukherjee S,Biswas J,Roy M

更新日期：2012-10-12 00:00:00

abstract：:Disturbances of serotonergic pathways have been implicated in a wide variety of neuropsychiatric disorders such as depression, anxiety, migraine, and substance abuse. Genetic variation in genes coding for serotonin receptor proteins might well be involved in the genetic predisposition to these diseases and/or of pharm...

journal_title：Biochemical and biophysical research communications

authors： Nöthen MM,Erdmann J,Shimron-Abarbanell D,Propping P

更新日期：1994-12-15 00:00:00

abstract：:Due to the structural and functional importance of tight turns, some methods have been proposed to predict gamma-turns, beta-turns, and alpha-turns in proteins. In the past, studies of pi-turns were made, but not a single prediction approach has been developed so far. It will be useful to develop a method for identify...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Xue ZD,Shi XH,Xu J

更新日期：2006-09-01 00:00:00

abstract：:Hepatitis B, a major public health concern worldwide, is caused by hepatitis type B virus, a hepdnavirus that infects only human and certain nonhuman primates, and replicates strictly in hepatocytes. By using the techniques of slot and Southern blot DNA hybridization, and electron microscopy, the presence of HBV was i...

journal_title：Biochemical and biophysical research communications

authors： Pao CC,Wu SY,Hung IJ,Ng KT,Liaw YF,Lo SJ

更新日期：1987-07-31 00:00:00

abstract：:It has been reported that mammalian cells incubated with excess nitric oxide (NO) accumulate p53 protein but concomitantly this p53 loses its capacity for binding to its DNA consensus sequence. As nitration of tyrosine residues in various proteins has been shown to inhibit their functions, we examined whether NO nitra...

journal_title：Biochemical and biophysical research communications

authors： Chazotte-Aubert L,Hainaut P,Ohshima H

更新日期：2000-01-19 00:00:00

abstract：:Human thymidine phosphorylase (dThdPase) is thought to be identical to an angiogenesis factor, platelet-derived endothelial cell growth factor (PD-ECGF). However, the whole amino acid sequence of dThdPase is still unknown. N-terminal amino acid sequencing of dThdPase isolated from human placenta gave the sequence Ac-A...

journal_title：Biochemical and biophysical research communications

authors： Miyadera K,Dohmae N,Takio K,Sumizawa T,Haraguchi M,Furukawa T,Yamada Y,Akiyama S

更新日期：1995-07-26 00:00:00

abstract：:ShcA proteins mediate Erk1/Erk2 activation by integrins and epidermal growth factor (EGF), and are expressed as p46ShcA, p52ShcA, and p66ShcA. Although p52ShcA and p46ShcA mediate Erk1/Erk2 activation, p66ShcA antagonizes Erk activation. p66ShcA is spatially regulated during lung development, leading us to hypothesize...

journal_title：Biochemical and biophysical research communications

authors： Smith SM,Crowe DL,Lee MK

更新日期：2006-04-14 00:00:00

abstract：:Nitric oxide (NO) produced by macrophages plays an important role in host defense and inflammation. We found that two agrochemicals, alachlor and carbaryl, inhibit lipopolysaccharide (LPS)-induced NO production by macrophages. In the present study, we investigated this inhibitory mechanism in RAW 264 cells. Both chemi...

journal_title：Biochemical and biophysical research communications

authors： Shimomura-Shimizu M,Sugiyama K,Muroi M,Tanamoto K

更新日期：2005-07-08 00:00:00

abstract：:The murine 3T3-L1 preadipocyte cell line is well characterized for its capacity to undergo differentiation into adipocytes under appropriate hormonal stimulation. p107, a member of the retinoblastoma tumor suppressor gene family has been shown to be dramatically upregulated during the early requisite clonal expansion ...

journal_title：Biochemical and biophysical research communications

authors： May JS,Prince AM,Lyle RE,McGehee RE Jr

更新日期：2001-05-18 00:00:00

abstract：:A Balb/c mouse was immunized with chick synaptic plasma membranes and monoclonal antibodies were produced by fusion of spleen cells with NS-1 mouse myeloma cells. One antibody, MAC-L1, immunoprecipitated more than 90% of the [3H]PN200-110-labeled calcium channels but only 20% of the omega -conotoxin receptor solubiliz...

journal_title：Biochemical and biophysical research communications

authors： Takahashi M,Fujimoto Y

更新日期：1989-09-15 00:00:00

abstract：:High altitude hypobaric hypoxia environment impairs male's reproductive function. Leptin is an adipose tissue-derived hormone which regulates body weight homeostasis. Its receptor (LepR) has been found in all levels of male reproductive axis, indicating that it can affect male reproductive system in a direct or (and) ...

journal_title：Biochemical and biophysical research communications

authors： Liu X,Liu S,Xu C

更新日期：2020-08-13 00:00:00

abstract：:We have cloned the cDNA encoding human PICK1 (protein interacting with C kinase 1), a PDZ domain-containing protein of 415 amino acids, and also identified the Drosophila homologue by search of the databank. Northern blot analysis shows a single mRNA of about 2.0 kb ubiquitously expressed in human tissues. Although PI...

journal_title：Biochemical and biophysical research communications

authors： Takeya R,Takeshige K,Sumimoto H

更新日期：2000-01-07 00:00:00

abstract：:(-)Bay K 8644 produced a concentration-dependent contraction of porcine coronary artery rings with the maximal contraction at 10(-6) M. Pretreatment of the rings with 10(-6) M nitrendipine inhibited (-)Bay K 8644-induced contraction, while pretreatment with 10(-8) M nitrendipine potentiated the contraction elicited by...

journal_title：Biochemical and biophysical research communications

authors： Miwa K,Schwartz A

更新日期：1987-10-14 00:00:00

abstract：:Ritonavir, an inhibitor of HIV-1 protease, has been reported to also inhibit the Ca2+-dependent cysteine protease, calpain. We have investigated these claims with an in vitro study of the effect of ritonavir on the m-calpain and mu-calpain isoforms. Ritonavir failed to block either autolytic or hydrolytic calpain acti...

journal_title：Biochemical and biophysical research communications

authors： Cuerrier D,Nie Z,Badley AD,Davies PL

更新日期：2005-02-04 00:00:00

abstract：:Heparin-binding EGF-like growth factor (HB-EGF) is a polypeptide with an apparent molecular weight of 22 kilodalton that is related to epidermal growth factor (EGF) and that binds and activates the EGF receptor. We examined HB-EGF biological action and expression in human pancreatic cancer cell lines, and compared HB-...

journal_title：Biochemical and biophysical research communications

authors： Kobrin MS,Funatomi H,Friess H,Buchler MW,Stathis P,Korc M

更新日期：1994-08-15 00:00:00

abstract：:Receptor activator of nuclear factor (NF)-κB ligand (RANKL)-activated signaling is essential for osteoclast differentiation, activation, and survival. Salicortin is a phenolic glycoside that has been isolated from many plants such as Populus and Salix species, and has been shown to have anti-amnesic and anti-adipogeni...

journal_title：Biochemical and biophysical research communications

authors： Nie S,Xu J,Zhang C,Xu C,Liu M,Yu D

更新日期：2016-01-29 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is known to play an essential role in vascular development. We have overexpressed VEGF122 or VEGF170, which are equivalent to mouse VEGF120 and VEGF164, in developing Xenopus embryos. Overexpression of VEGF170 but not VEGF122 demonstrated an absence of expression of hematopoie...

journal_title：Biochemical and biophysical research communications

authors： Koibuchi N,Taniyama Y,Nagao K,Ogihara T,Kaneda Y,Morishita R

更新日期：2006-05-26 00:00:00

abstract：:1,25-Dihydroxyvitamin D(3) [1,25(OH)(2) D(3)] exerts its biological effects by binding to the vitamin D receptor (VDR), which binds in turn to the vitamin D response elements located in the target gene's promoter. We have previously demonstrated that VDR binds in vitro with high affinity to the 5'-flanking sequence of...

journal_title：Biochemical and biophysical research communications

authors： Seoane S,Alonso M,Segura C,Pérez-Fernández R

更新日期：2002-03-22 00:00:00

abstract：:Ribosomal protein S6 phosphorylation is stimulated by a variety of hormones and growth factors. In mammalian cells the predominant S6 kinase is a 70 kDa enzyme which exists in two forms differing only in their amino terminal region. To determine whether this difference is functionally significant we have examined the ...

journal_title：Biochemical and biophysical research communications

authors： Coffer PJ,Woodgett JR

更新日期：1994-01-28 00:00:00

abstract：:Brewers yeast contains factors that increase and decrease glucose tolerance. Hop components (lupulones) that adhere to yeast during the brewing process elicit a variety of biological effects including the induction of hepatic cytochrome P4503A. Colupulone was tested for its effects on glucose tolerance and cytochrome ...

journal_title：Biochemical and biophysical research communications

authors： Mannering GJ,Shoeman JA,Shoeman DW

更新日期：1994-05-16 00:00:00

abstract：:Group II chaperonins (Cpns) are essential mediators of cellular protein folding in eukaryotes and archaea. They consist of two back-to-back rings forming symmetrical cavities in which non-native substrates undergo appropriate folding, but the primary structural basis for the double ring formation remains unclear. To a...

journal_title：Biochemical and biophysical research communications

authors： Luo H,Zhang P,Robb FT

更新日期：2011-09-23 00:00:00

abstract：:Fission yeast cell division is initiated by the cdc2/cdc13-cyclin protein kinase which in its catalytically active state comprises the mitotic inducer. During interphase the cdc2/cyclin complex is assembled in an inactive state that requires cdc25+ gene function for M-phase activation. The cdc25+ product, a 76 kd phos...

journal_title：Biochemical and biophysical research communications

authors： Ducommun B,Draetta G,Young P,Beach D

更新日期：1990-02-28 00:00:00

abstract：:Recent studies indicate that galactoside-binding proteins may bind the poly-N-acetyllactosamine sequences of laminin. We questioned whether human galactoside-binding protein (hL-31) binds to laminin and whether cells that express hL-31 on their surface use it as a laminin receptor to promote cellular attachment. The d...

journal_title：Biochemical and biophysical research communications

authors： Ochieng J,Gerold M,Raz A

更新日期：1992-08-14 00:00:00

abstract：:Lysophosphatidic acid (LPA) receptors belong to G protein-coupled transmembrane receptors (LPA receptors; LPA(1) to LPA(6)). They indicate a variety of cellular response by the interaction with LPA, including cell proliferation, migration and differentiation. Recently, we have reported that constitutive active mutated...

journal_title：Biochemical and biophysical research communications

authors： Kitayoshi M,Kato K,Tanabe E,Yoshikawa K,Fukui R,Fukushima N,Tsujiuchi T

更新日期：2012-06-01 00:00:00

abstract：:Specific ligands of the peripheral benzodiazepine receptor (PBR) have been shown to induce both apoptosis and G1/G0 cell cycle arrest in colorectal cancers. The signaling pathways leading to cell cycle arrest are still unknown. Using cDNA array technology, we identified signaling molecules involved in cell cycle arres...

journal_title：Biochemical and biophysical research communications

authors： Maaser K,Sutter AP,Krahn A,Höpfner M,Grabowski P,Scherübl H

更新日期：2004-11-12 00:00:00

abstract：:Replication of mammalian chromosomes depends on the activation of a large number of origins of DNA replication distributed along the chromosomes. We have focused our attention on a human DNA region, named ARSH1, localized to chromosome 2, that had been previously shown to act as an episomal origin in the yeast Sacchar...

journal_title：Biochemical and biophysical research communications

authors： Hu L,Xu X,Valenzuela MS

更新日期：2004-01-23 00:00:00

abstract：:Upon incubation of bovine thyroglobulin with trypsin at high enzyme/substrate ratio, some fragments with apparent masses between 18 and 31 kDa resisted prolonged digestion. Their NH2-terminal sequences were determined. All fragments overlapped with some of the Cys-rich repeats that compose a large part of thyroglobuli...

journal_title：Biochemical and biophysical research communications

authors： Gentile F,Palumbo G

更新日期：1993-11-15 00:00:00