当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Nitric oxide nitrates tyrosine residues of tumor-suppressor p53 protein in MCF-7 cells.

Nitric oxide nitrates tyrosine residues of tumor-suppressor p53 protein in MCF-7 cells.

Abstract：

:It has been reported that mammalian cells incubated with excess nitric oxide (NO) accumulate p53 protein but concomitantly this p53 loses its capacity for binding to its DNA consensus sequence. As nitration of tyrosine residues in various proteins has been shown to inhibit their functions, we examined whether NO nitrates tyrosine residues in p53 protein. MCF-7 cells expressing wild-type p53 were incubated with S-nitrosoglutathione for 4 h and cellular extracts were immunoprecipitated with an anti-p53 antibody. Western blot analyses of immunoprecipitates for p53 or for nitrotyrosine revealed low levels of nitrotyrosine in p53 from untreated cells. Incubation with 2 mM S-nitrosoglutathione induced a significant increase in the nitrotyrosine level in p53 protein compared to nontreated cells. These results suggest that excess NO produced in inflamed tissues could nitrate p53 protein, playing a role in carcinogenesis by impairing functions of this tumor-suppressor protein.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Chazotte-Aubert L,Hainaut P,Ohshima H

doi

10.1006/bbrc.1999.2003

subject

Has Abstract

pub_date

2000-01-19 00:00:00

pages

609-13

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(99)92003-X

journal_volume

267

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Anti-citrullinated collagen type I antibody is a target of autoimmunity in rheumatoid arthritis.

    abstract：:Rheumatoid arthritis (RA) is one of the most common autoimmune diseases, but its autoimmune mechanisms are not clearly understood. Recently, anti-citrullinated peptide antibodies have been specifically observed in sera of RA patients. Furthermore, we identified RA-susceptible variant in a gene encoding citrullinating ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.bbrc.2005.05.137

    authors： Suzuki A,Yamada R,Ohtake-Yamanaka M,Okazaki Y,Sawada T,Yamamoto K

    更新日期：2005-07-29 00:00:00

  • Lung oxidative metabolism after exposure to ambient particles.

    abstract：:The aim of this work was to study the time course of the oxidative metabolism in mice lung after exposure to ambient particles (ROFA). Swiss mice were intranasally instilled with a ROFA suspension (0.20 mg/kg). Animals were sacrificed 1 or 3 h after the exposure. Eighty percentage of increased oxygen consumption was o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.08.021

    authors： Magnani ND,Marchini T,Tasat DR,Alvarez S,Evelson PA

    更新日期：2011-09-09 00:00:00

  • Soluble factors including proteinases released from damaged cells may trigger the wound healing process.

    abstract：:The wound healing process is initiated as soon as tissue is injured. Herein, we demonstrate that c-fos and c-myc mRNA transcripts are promptly increased in the wounded tissue in vivo and in vitro. A buffer solution from scraped serum-starved quiescent fibroblasts, when added to resting fibroblasts, caused the increase...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91151-h

    authors： Tsuboi K,Yamaoka S,Maki M,Ohshio G,Tobe T,Hatanaka M

    更新日期：1990-05-16 00:00:00

  • MAP kinase phosphorylation of plant profilin.

    abstract：:Profilin is a small actin-binding protein and is expressed at high levels in mature pollen where it is thought to regulate actin filament dynamics upon pollen germination and tube growth. The majority of identified plant profilins contain a MAP kinase phosphorylation motif, P-X-T-P, and a MAP kinase interaction motif ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.09.071

    authors： Limmongkon A,Giuliani C,Valenta R,Mittermann I,Heberle-Bors E,Wilson C

    更新日期：2004-11-05 00:00:00

  • CRL4DCAF8 and USP11 oppositely regulate the stability of myeloid leukemia factors (MLFs).

    abstract：:Myeloid leukemia factors (MLF1 and MLF2) are proteins associated with leukemia and several other cancers. However, little is known about the regulatory mechanisms underlying the stability of these proteins. Here, we show that DDB1 and CUL4 associated factor 8 (DCAF8), which can form a functional E3 ligase complex (CRL...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.05.186

    authors： Huang D,Liu C,Sun X,Sun X,Qu Y,Tang Y,Li G,Tong T

    更新日期：2020-08-20 00:00:00

  • Analysis of cardiomyocyte movement in the developing murine heart.

    abstract：:The precise assemblage of several types of cardiac precursors controls heart organogenesis. The cardiac precursors show dynamic movement during early development and then form the complicated heart structure. However, cardiomyocyte movements inside the newly organized mammalian heart remain unclear. We previously esta...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.07.036

    authors： Hashimoto H,Yuasa S,Tabata H,Tohyama S,Seki T,Egashira T,Hayashiji N,Hattori F,Kusumoto D,Kunitomi A,Takei M,Kashimura S,Yozu G,Shimojima M,Motoda C,Muraoka N,Nakajima K,Sakaue-Sawano A,Miyawaki A,Fukuda K

    更新日期：2015-09-04 00:00:00

  • Modulation of fluoropyrimidine metabolism by chlorpromazine.

    abstract：:Chlorpromazine is a potent inhibitor of calmodulin and can alter the accumulation, metabolism, and incorporation into RNA of several fluoropyrimidine drugs. Using S-180 murine sarcoma cells, the accumulation of the base Fluorouracil and its metabolism to ribonucleotides is enhanced by chlorpromazine treatment, as meas...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80596-4

    authors： Tseng A Jr,Brooks M,Cadman E

    更新日期：1986-07-31 00:00:00

  • Calcium modulation of mitochondrial inner membrane channel activity.

    abstract：:Protocols were defined that enable patch-clamp studies of the approximately 107 pS voltage dependent channel and a class of activity we refer to as MCC (multiconductance channel) which is characterized by multiple levels and transitions as high as 1 to 1.5 nS. If free calcium was kept at 10(-7) M or lower during mitoc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)90410-9

    authors： Kinnally KW,Zorov D,Antonenko Y,Perini S

    更新日期：1991-05-15 00:00:00

  • p73-dependent induction of 14-3-3sigma increases the chemo-sensitivity of drug-resistant human breast cancers.

    abstract：:It has been well documented that tumor suppressor p53 is mutated in about 50% of all human tumors. p53 status might be one of the critical determinants for the chemo-sensitivity of human tumors. In the present study, we have found that p53 family member p73 as well as 14-3-3sigma is down-regulated in response to adria...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.06.079

    authors： Sang M,Li Y,Ozaki T,Ono S,Ando K,Yamamoto H,Koda T,Geng C,Nakagawara A

    更新日期：2006-08-18 00:00:00

  • Stimulation of the class-A scavenger receptor induces neutrophil extracellular traps (NETs) by ERK dependent NOX2 and ROMO1 activation.

    abstract：:Neutrophil extracellular traps (NETs) play a critical role in host antimicrobial response whereas they are also implicated in the pathogenesis of inflammatory and autoimmunediseases. Generation of reactiveoxygen species (ROS) is key to NETs formation. A variety of stimulatory ligands have been found to enhance ROS pro...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.02.142

    authors： Zhu Y,Yang Y,Li F,Fan S,Chen X,Lu Y,Wei Y,Chen Q,Xia L,Tang J,Huang Q,Zhu Q,Zheng J,Liu X

    更新日期：2019-04-16 00:00:00

  • Periplasmic proteins of Escherichia coli are highly resistant to aggregation: reappraisal for roles of molecular chaperones in periplasm.

    abstract：:Periplasmic proteins of Gram-negative bacteria like Escherichia coli are subjected to immediate affect of environmental fluctuation that may unfold proteins, due to the permeability of the outer membrane to small molecules. They are thus supposedly protected by certain molecular chaperones. Nevertheless, no homologues...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.02.125

    authors： Liu Y,Fu X,Shen J,Zhang H,Hong W,Chang Z

    更新日期：2004-04-09 00:00:00

  • Salmon calcitonin binding and stimulation of cyclic AMP generation in rat skeletal muscle.

    abstract：:Salmon calcitonin potently competes for amylin binding sites in rat brain and has amylin-like actions upon glucose metabolism in rat muscle. We report here that [125I]-salmon calcitonin binds to rat hindlimb muscle membranes with high affinity (Kd = 0.47 pM). Binding was inhibited by rat amylin (Ki = 2 nM), rat alpha ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2433

    authors： Kenney MA,Moore CX,Pittner R,Beaumont K

    更新日期：1993-11-30 00:00:00

  • Anthelmintic drug niclosamide enhances the sensitivity of chronic myeloid leukemia cells to dasatinib through inhibiting Erk/Mnk1/eIF4E pathway.

    abstract：:Chronic myeloid leukemia (CML) responds well to BCR-ABL tyrosine kinase inhibitors (TKI), but becomes resistant to TKIs after it progresses to blast phase (BP). Here we show that niclosamide, a FDA-approved anthelmintic drug, enhances the sensitivity of BP-CML cells to dasatinib (2nd generation of BCR-ABL TKI) through...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.08.047

    authors： Liu Z,Li Y,Lv C,Wang L,Song H

    更新日期：2016-09-16 00:00:00

  • Phenobarbital-elicited activation of nuclear receptor CAR in induction of cytochrome P450 genes.

    abstract：:Phenobarbital (PB) increases metabolic capability of hepatocytes by its ability to activate numerous genes encoding various xenochemical-metabolizing enzymes such as cytochrome P450s and specific transferases. More than 35 years since PB induction was first reported, the key nuclear receptor CAR that mediates the indu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1006/bbrc.2000.3557

    authors： Zelko I,Negishi M

    更新日期：2000-10-14 00:00:00

  • Computer studies on the stereostructure and quantum chemical properties of 6-pyruvoyl tetrahydropterin, the key intermediate of tetrahydrobiopterin biosynthesis.

    abstract：:The optimized geometry of the conformation of atoms constituting the 6-pyruvoyl tetrahydropterin molecule, the labile key intermediate of tetrahydrobiopterin biosynthesis, was obtained by molecular orbital calculations within the MINDO/3 framework. The stereostructure of the molecule showing the preferred mode for bin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)90888-e

    authors： Katoh S,Sueoka T,Kurihara T

    更新日期：1991-04-15 00:00:00

  • Contribution of a putative salt bridge and backbone dynamics in the structural instability of human prion protein upon R208H mutation.

    abstract：:Molecular dynamics simulation method is used to assess the contribution of a disease-associated salt bridge in the early stages of the conformational rearrangement of human prion protein upon Arg208-->His mutation, which causes Creutzfeldt-Jakob disease. Previous investigations have suggested that the breakage of this...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.10.011

    authors： Bamdad K,Naderi-Manesh H

    更新日期：2007-12-28 00:00:00

  • microRNA-495 promotes bladder cancer cell growth and invasion by targeting phosphatase and tensin homolog.

    abstract：:Accumulating evidence has linked deregulation of microRNA-495 (miR-495) to tumorigenesis; however, its function in tumor progression is controversial. This work was undertaken to explore the expression and biological roles of miR-495 in bladder cancer. The expression of miR-495 was examined in 67 pairs of bladder canc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.01.019

    authors： Tan M,Mu X,Liu Z,Tao L,Wang J,Ge J,Qiu J

    更新日期：2017-02-05 00:00:00

  • Bioluminescent system for dynamic imaging of cell and animal behavior.

    abstract：:The current utility of bioluminescence imaging is constrained by a low photon yield that limits temporal sensitivity. Here, we describe an imaging method that uses a chemiluminescent/fluorescent protein, ffLuc-cp156, which consists of a yellow variant of Aequorea GFP and firefly luciferase. We report an improvement in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.01.141

    authors： Hara-Miyauchi C,Tsuji O,Hanyu A,Okada S,Yasuda A,Fukano T,Akazawa C,Nakamura M,Imamura T,Matsuzaki Y,Okano HJ,Miyawaki A,Okano H

    更新日期：2012-03-09 00:00:00

  • Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28.

    abstract：:The human 5-HT1A receptor was screened for naturally occurring mutations. The PCR product of the 5-HT1A receptor gene was digested with several restriction enzymes and evaluated by single-strand conformational polymorphism (SSCP) analysis. Comparison of the SSCP electrophoretic pattern with a restriction map of the 5-...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1692

    authors： Nakhai B,Nielsen DA,Linnoila M,Goldman D

    更新日期：1995-05-16 00:00:00

  • Allergic asthma aggravated atherosclerosis increases cholesterol biosynthesis and foam cell formation in apolipoprotein E-deficient mice.

    abstract：:Several studies have demonstrated that allergic asthma can induce atherosclerosis formation in mice. Moreover, allergic asthma and atherosclerosis have been shown to be strongly associated with dyslipidemia. In this study, we investigated the underlying mechanism of allergic asthma-aggravated atherosclerosis-induced c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.09.085

    authors： Gao S,Wang C,Li W,Shu S,Zhou J,Yuan Z,Wang L

    更新日期：2019-11-19 00:00:00

  • The alpha2-adrenoreceptor agonist dexmedetomidine protects against lipopolysaccharide-induced apoptosis via inhibition of gap junctions in lung fibroblasts.

    abstract：:The α2-adrenoceptor inducer dexmedetomidine protects against acute lung injury (ALI), but the mechanism of this effect is largely unknown. The present study investigated the effect of dexmedetomidine on apoptosis induced by lipopolysaccharide (LPS) and the relationship between this effect and gap junction intercellula...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.10.162

    authors： Zhang Y,Tan X,Xue L

    更新日期：2018-01-01 00:00:00

  • Immunohistological detection of BRAF25 in human prostate tumor and cancer specimens.

    abstract：:BRAF25 is an alternatively spliced protein of BRAF35 (see associated paper). We have mapped the BRAF25 gene to chromosome sub-band 19p13.3, a region where loss of chromosomal heterozygosity has been reported in about 50% of ovarian cancers. Because of the high incidence of genetic links of prostate cancer to breast an...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)00625-3

    authors： Wang C,McCarty IM,Balazs L,Li Y,Steiner MS

    更新日期：2002-07-05 00:00:00

  • Suppression of HIF-1α accumulation by betulinic acid through proteasome activation in hypoxic cervical cancer.

    abstract：:Betulinic acid (BA) exhibits various biological activities such as anti-bacterial, anti-inflammatory, anti-human papilloma virus (HPV), and anti-cancer activities. HPV infection is associated with a high risk of cervical cancer, which is the leading cause of deaths among women worldwide. Therefore, BA is an attractive...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.01.031

    authors： Kim HJ,Cho HS,Ban HS,Nakamura H

    更新日期：2020-03-12 00:00:00

  • Activation mechanism of solubilized epidermal growth factor receptor tyrosine kinase.

    abstract：:Dimerization of epidermal growth factor receptor (EGFR) leads to the activation of its tyrosine kinase. To elucidate whether dimerization is responsible for activation of the intracellular tyrosine kinase domain or just plays a role in the stabilization of the active form, the activated status of wild-type EGFR moiety...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.6285

    authors： Ge G,Wu J,Wang Y,Lin Q

    更新日期：2002-01-25 00:00:00

  • eIF4E binding protein 1 and H-Ras are novel substrates for the protein kinase activity of class-I phosphoinositide 3-kinase.

    abstract：:Class-I phosphoinositide 3-kinases (PI 3-kinases) are dual specificity enzymes that possess both lipid and protein kinase activity. While the best characterized property of this protein kinase is as an autokinase activity, there have also been reports it can phosphorylate exogenous substrates including peptides, IRS-1...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.04.191

    authors： Foukas LC,Shepherd PR

    更新日期：2004-06-25 00:00:00

  • MicroRNA-939 governs vascular integrity and angiogenesis through targeting γ-catenin in endothelial cells.

    abstract：:Coronary collateral circulation (CCC) functions as a natural bypass in the event of coronary obstruction, which markedly improves prognosis in patients with coronary artery disease (CAD). MicroRNAs (miRNAs) have been implicated in multiple physiological and pathological processes, including angiogenesis involved in CC...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.01.085

    authors： Hou S,Fang M,Zhu Q,Liu Y,Liu L,Li X

    更新日期：2017-02-26 00:00:00

  • Silencer-mediated repression and non-mediated activation of BDNF and c-fos gene promoters in primary glial or neuronal cells.

    abstract：:Although the neuron-restrictive silencer element (NRSE/Regard) has been shown to function as a negative-acting DNA regulatory element to prevent the expression of neuron-specific genes in non-neuronal cells, little is known about its silencing effect on transcription in primary glial cells nor its effect on transcript...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0974

    authors： Tabuchi A,Nakatani C,Nakaoka R,Naruse Y,Kojima T,Mori N,Tsuda M

    更新日期：1999-08-02 00:00:00

  • Spectral evidence for non-calcium interactions of intracellular Indo-1.

    abstract：:Indo-1 is widely used to measure intracellular free calcium, [Ca2+]i, by comparing the fluorescence emission at 2 or more wavelengths with the emissions, which are assumed to be known, of Indo-1 when it is fully calcium-bound and when it is fully calcium-free. Accurate quantitation requires that these "reference" valu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92139-6

    authors： Owen CS,Shuler RL

    更新日期：1989-08-30 00:00:00

  • Effect of endothelin-1 on release of arginine-vasopressin from perifused rat hypothalamus.

    abstract：:Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictor peptide with potent pressor activity. We studied the effect of ET-1 on release of arginine-vasopressin (AVP) from perifused rat hypothalamus. ET-1 (10(-10) to 10(-8) M) significantly stimulated AVP release. The ET-1-induced AVP release was completely blocke...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)91124-8

    authors： Shichiri M,Hirata Y,Kanno K,Ohta K,Emori T,Marumo F

    更新日期：1989-09-29 00:00:00

  • Serum withdrawal induces apoptotic cell death in Ki-ras transformed but not in normal differentiated thyroid cells.

    abstract：:Thyroid cells transformed by the Kirsten-ras oncogene become tumorigenic in syngeneic animals. Their growth is no longer dependent on TSH but becomes dependent on serum. Combining morphological and biochemical evidence, we show that serum withdrawal induces apoptotic cell death in Kirsten and Harvey-ras transformed th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2360

    authors： di Jeso B,Ulianich L,Racioppi L,D'Armiento F,Feliciello A,Pacifico F,Consiglio E,Formisano S

    更新日期：1995-09-25 00:00:00