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Analysis of cardiomyocyte movement in the developing murine heart.

Abstract：

:The precise assemblage of several types of cardiac precursors controls heart organogenesis. The cardiac precursors show dynamic movement during early development and then form the complicated heart structure. However, cardiomyocyte movements inside the newly organized mammalian heart remain unclear. We previously established the method of ex vivo time-lapse imaging of the murine heart to study cardiomyocyte behavior by using the Fucci (fluorescent ubiquitination-based cell cycle indicator) system, which can effectively label individual G1, S/G2/M, and G1/S-transition phase nuclei in living cardiomyocytes as red, green, and yellow, respectively. Global analysis of gene expression in Fucci green positive ventricular cardiomyocytes confirmed that cell cycle regulatory genes expressed in G1/S, S, G2/M, and M phase transitions were upregulated. Interestingly, pathway analysis revealed that many genes related to the cell cycle were significantly upregulated in the Fucci green positive ventricular cardiomyocytes, while only a small number of genes related to cell motility were upregulated. Time-lapse imaging showed that murine proliferating cardiomyocytes did not exhibit dynamic movement inside the heart, but stayed on site after entering the cell cycle.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hashimoto H,Yuasa S,Tabata H,Tohyama S,Seki T,Egashira T,Hayashiji N,Hattori F,Kusumoto D,Kunitomi A,Takei M,Kashimura S,Yozu G,Shimojima M,Motoda C,Muraoka N,Nakajima K,Sakaue-Sawano A,Miyawaki A,Fukuda K

doi

10.1016/j.bbrc.2015.07.036

subject

Has Abstract

pub_date

2015-09-04 00:00:00

pages

1000-1007

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(15)30267-9

journal_volume

464

pub_type

杂志文章

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