当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Expression of P-glycoprotein in L1210 cells is linked with rise in sensitivity to Ca2+.

Expression of P-glycoprotein in L1210 cells is linked with rise in sensitivity to Ca2+.

Abstract：

:L1210/VCR cell line (R) was obtained by adaptation of the L1210 mouse leukaemia cells (S) to vincristine and showed P-glycoprotein (P-gp) mediated multidrug resistance (MDR). R cells were observed to be more sensitive to high external calcium as parental S. More pronounced calcium uptake was observed for R cells. Moreover, differences in intracellular calcium cell localization between S and R cells were found ultrastructurally following a calcium precipitating cytochemical method. In S cells, calcium precipitates were found to be localized predominantly along the cell surface coat and within mitochondria delineating the cristae. In R cells, precipitates were also found inside nuclei, at the border of heterochromatin clumps, and scattered within the cytoplasm. High extracellular calcium did not influence the P-gp mediated extrusion of calcein/AM as P-gp substrate. These results indicate that calcium enters and consequently damages the MDR cells to a higher extent than parental cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sulová Z,Orlický J,Fiala R,Dovinová I,Uhrík B,Seres M,Gibalová L,Breier A

doi

10.1016/j.bbrc.2005.07.144

subject

Has Abstract

pub_date

2005-09-30 00:00:00

pages

777-84

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)01627-X

journal_volume

335

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Mitochondrial localization of fission yeast manganese superoxide dismutase is required for its lysine acetylation and for cellular stress resistance and respiratory growth.

    abstract：:Manganese-dependent superoxide dismutase (MnSOD) is localized in the mitochondria and is important for oxidative stress resistance. Although transcriptional regulation of MnSOD has been relatively well studied, much less is known about the protein's posttranslational regulation. In budding yeast, MnSOD is activated af...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.01.103

    authors： Takahashi H,Suzuki T,Shirai A,Matsuyama A,Dohmae N,Yoshida M

    更新日期：2011-03-04 00:00:00

  • Three growth hormone- and two prolactin-related novel peptides of Mr 13,000-18,000 identified in the anterior pituitary.

    abstract：:Electrophoretic analysis of murine anterior pituitary extract revealed five major proteins of Mr 13,000-18,000 (designated P13, P14, P16, P17, and P18 according to Mr), three of which, P16, P17, and P18, were markedly influenced by estradiol benzoate and perphenazine in a manner similar to that of growth hormone, and ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80820-9

    authors： Sinha YN,Jacobsen BP

    更新日期：1988-10-14 00:00:00

  • Differential regulation of multiple neuroreceptors in a somatic cell hybrid by inhibitors of glycoprotein processing.

    abstract：:Specific binding of [3H][D-Ala2,D-Leu5]enkephalin, [3H]ethylketocyclazocine, 5-[3H]hydroxytryptamine, and [3H]spiperone was examined in neuroblastoma-brain hybrid cell line NCB-20 following exposure to inhibitors of N-linked protein glycosylation (tunicamycin, TM) and oligosaccharide processing (swainsonine, SW). TM t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90403-1

    authors： McLawhon RW,Berry-Kravis E,Dawson G

    更新日期：1986-02-13 00:00:00

  • Dissecting the cosubstrate structure requirements of the Staphylococcus aureus aminoglycoside resistance enzyme ANT(4').

    abstract：:Aminoglycosides are important antibiotics used against a wide range of pathogens. As a mechanism of defense, bacteria have evolved enzymes able to inactivate these drugs by regio-selectively adding a variety of functionalities (acetyl, phospho, and nucelotidyl groups) to their scaffolds. The aminoglycoside nucleotidyl...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.10.119

    authors： Porter VR,Green KD,Zolova OE,Houghton JL,Garneau-Tsodikova S

    更新日期：2010-12-03 00:00:00

  • Bone morphogenetic protein signalling in NGF-stimulated PC12 cells.

    abstract：:Bone morphogenetic proteins (BMPs) are shown to potentiate NGF-induced neuronal differentiation in PC12 phaeochromocytoma cells grown on collagen under low-serum conditions. Whereas, cell bodies remained rounded in control medium or with only BMPs present, addition of BMP4 or BMP6 robustly increased the neuritogenic e...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)01236-1

    authors： Althini S,Usoskin D,Kylberg A,ten Dijke P,Ebendal T

    更新日期：2003-08-01 00:00:00

  • Characterization of the BUD31 gene of Saccharomyces cerevisiae.

    abstract：:A number of genes have been identified in the fully sequenced genome of Saccharomyces cerevisiae that appear to be conserved throughout evolution and the function of which remains poorly understood. In this manuscript we describe the initial characterization of yeast BUD31 gene. cDNA sequences highly related to BUD31 ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.05.228

    authors： Masciadri B,Areces LB,Carpinelli P,Foiani M,Draetta G,Fiore F

    更新日期：2004-08-06 00:00:00

  • ERRF is essential for Estrogen-Estrogen Receptor alpha signaling pathway in ER positive breast cancer cells.

    abstract：:Estrogen-Estrogen Receptor alpha (ERα) belongs to one of the most important signaling pathways controlling breast tissue development and progression of breast cancer. ERRF was recently identified as a candidate breast cancer associated protein and showed positive association with ERα status in clinical samples and cel...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.04.132

    authors： Luo A,Zhang X

    更新日期：2016-05-27 00:00:00

  • Characteristics of alpha-adrenoceptors in two human colorectal cancer cell lines.

    abstract：:The DiFi and HT-29 human colorectal cancer cell lines were characterized and compared with respect to binding properties of alpha adrenoceptors present on the cell surface. Both cell lines possessed alpha-1 and alpha-2 adrenoceptors of high affinity; however, DiFi cells were rich in alpha-1 adrenoceptors, whereas HT-2...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)80972-6

    authors： Agrawal DK,Wildrick DM,Boman BM

    更新日期：1992-05-29 00:00:00

  • Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase.

    abstract：:Little is known as to the structural requirements of the acyl side chain for interaction of acylglycerols with monoacylglycerol lipase (MAGL), the enzyme chiefly responsible for the metabolism of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain. In the present study, a series of twelve analogues of 1-AG ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.09.015

    authors： Vandevoorde S,Saha B,Mahadevan A,Razdan RK,Pertwee RG,Martin BR,Fowler CJ

    更新日期：2005-11-11 00:00:00

  • Expression and characterization of a rabbit liver cytochrome P450 belonging to P450IIB subfamily with the aid of the baculovirus expression vector system.

    abstract：:Using baculovirus a cDNA for cytochrome P450 (P450F1) belonging to rabbit P450IIB subfamily was expressed in Spodoptera frugiperda cells, where P450F1 was located on electron-dense structures (derived from the endoplasmic reticulum) present in both the cytoplasm and nucleus. Partially purified P450F1 exhibited absorpt...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91577-y

    authors： Ohta D,Matsu-ura Y,Sato R

    更新日期：1991-03-15 00:00:00

  • Morphine-mimetic anti-paratypic antibodies: cross-reactive properties.

    abstract：:Polyclonal, anti-idiotypic, rabbit antibodies have been raised against four murine monoclonal anti-morphine Fab fragments. The antibody preparations, after affinity purification, have been shown to contain an anti-paratypic fraction which reversibly inhibits morphine binding to the anti-morphine antibodies and to cell...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90458-4

    authors： Glasel JA,Pelosi LA

    更新日期：1986-05-14 00:00:00

  • Circular RNA circ-CBFB promotes proliferation and inhibits apoptosis in chronic lymphocytic leukemia through regulating miR-607/FZD3/Wnt/β-catenin pathway.

    abstract：:Circular RNA (circRNA) belongs to the non-coding RNA family and is involved in various human cancers, such as lung cancer and colorectal cancer. Nevertheless, whether circRNA expression is related to chronic lymphocytic leukemia (CLL) progression remains largely unclear. In our study, we investigated the role of circ-...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.06.045

    authors： Xia L,Wu L,Bao J,Li Q,Chen X,Xia H,Xia R

    更新日期：2018-09-03 00:00:00

  • Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein.

    abstract：:The Bcl-2 oncoprotein is a potent inhibitor of apoptosis and is overexpressed in a variety of different malignancies. Bcl-2 function is regulated through heterodimerization with other members of the Bcl-2 protein family. In addition, several proteins that are not members of the Bcl-2 family can bind to Bcl-2, includin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5512

    authors： Antoku K,Maser RS,Scully WJ Jr,Delach SM,Johnson DE

    更新日期：2001-09-07 00:00:00

  • Over-expression of Mxi1 represses renal epithelial tubulogenesis through the reduction of matrix metalloproteinase 9.

    abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disease. ADPKD is characterized by cyst development that leads to abnormal kidney structure. Renal tubules are a fundamental unit of architecture, so controls of tubular growth and formation are important for proper kidney functio...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.02.002

    authors： Song SA,Yoo KH,Ko JY,Kim BH,Yook YJ,Park JH

    更新日期：2012-03-16 00:00:00

  • Molecular size of the Na+-H+ antiport in renal brush border membranes, as estimated by radiation inactivation.

    abstract：:The radiation inactivation method was applied to brush border membrane vesicles from rat kidney, in order to estimate the molecular size of the Na+-H+ antiporter. Sodium influx (1mM) driven by an acid intravesicular pH was unaffected by the high osmolarity of the cryoprotective solution. Initial rate of influx was est...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80739-3

    authors： Béliveau R,Demeule M,Potier M

    更新日期：1988-04-15 00:00:00

  • Supramolecular surfactants: amphiphilic polymers designed to disrupt lipid membranes.

    abstract：:Simple polyesters derived from poly(ethylene glycol)s and alpha, omega-dicarboxylic acids exhibit a broad range of activity in disrupting phospholipid membranes. This activity has been analyzed by measuring the release of liposome-encapsulated 5(6)-carboxy-fluorescein (CF). Comparison with an analogous monomeric surfa...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)90031-4

    authors： Regen SL,Jayasuriya N,Fabianowski W

    更新日期：1989-03-15 00:00:00

  • Platelet surface membranes are highly mitogenic for coronary artery smooth muscle cells--A novel mechanism for sustained proliferation after vessel injury?

    abstract：:The effects of isolated platelet surface membranes on DNA synthesis and proliferation of bovine coronary artery smooth muscle cells (SMC) were studied. Platelet membranes were very potent mitogens for SMC. The potency was about 10-fold higher than the maximum effects of platelet-derived growth factor-BB (PDGF). Platel...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0793

    authors： Weber AA,Zucker TP,Schrör K

    更新日期：1999-06-07 00:00:00

  • The role of calpastatin (the specific calpain inhibitor) in myoblast differentiation and fusion.

    abstract：:Using red cells as an experimental model, we previously showed that a limited degradation of certain membrane proteins by calpain (Ca2+-activated thiol protease) was a necessary prerequisite for cell fusion and that fusibility depended on the ratio of calpain to its endogenous inhibitor calpastatin. Here we show that ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0509

    authors： Barnoy S,Glasner T,Kosower NS

    更新日期：1996-03-27 00:00:00

  • Modulation of rat liver protein kinase C during "in vivo" CC14-induced oxidative stress.

    abstract：:Rat intoxication with a single dose of the hepatotoxin carbon tetrachloride induces a significant modification of liver protein kinase C total activity which depends on the degree of the intrahepatocyte oxidative unbalance provoked by various concentrations of the haloalkane. Low carbon tetrachloride amounts stimulate...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1868

    authors： Pronzato MA,Domenicotti C,Rosso E,Bellocchio A,Patrone M,Marinari UM,Melloni E,Poli G

    更新日期：1993-07-30 00:00:00

  • Involvement of calponin and caldesmon in sustained contraction of arterial smooth muscle.

    abstract：:The molecular mechanism of smooth muscle contraction was approached by a novel method, covalent 14C-labeling. Intra- and intermolecular protein interactions during contractile activity are reflected by changed reactivity of protein side chains; these can be detected by reagents which readily permeate through the muscl...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)91274-t

    authors： Bárány K,Polyák E,Bárány M

    更新日期：1992-09-16 00:00:00

  • Identification of novel dendritic cell subset markers in human blood.

    abstract：:Human dendritic cells (DC) are key regulators of innate and adaptive immunity that can be divided in at least three major subpopulations: plasmacytoid DC (pDC), myeloid type 1 DC (mDC1) and myeloid type 2 DC (mDC2) exhibiting different functions. However, research, diagnostic and cell therapeutic studies on human DC s...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.11.112

    authors： Schütz F,Hackstein H

    更新日期：2014-01-10 00:00:00

  • Serum profiling based on fucosylated glycoproteins for differentiating between chronic hepatitis B and hepatocellular carcinoma.

    abstract：:Chronic infection with hepatitis B virus (HBV) is associated with the majority of cases of hepatocellular carcinoma (HCC) in China. Despite this, there is no effective method for the early detection of HBV-induced liver cancer. Aberrant fucosylation is known to occur during the development of HCC. We, therefore, devel...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.02.155

    authors： Liao J,Zhang R,Qian H,Cao L,Zhang Y,Xu W,Li J,Wu M,Yin Z

    更新日期：2012-04-06 00:00:00

  • A chemiluminescence-based reporter system to monitor nonsense-mediated mRNA decay.

    abstract：:Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that mediates rapid degradation of transcripts bearing premature translation termination codons (PTCs) and thereby limits the expression of unproductively processed mRNAs and the synthesis of C-terminally truncated peptides. Both its importance as a means to...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.08.017

    authors： Boelz S,Neu-Yilik G,Gehring NH,Hentze MW,Kulozik AE

    更新日期：2006-10-13 00:00:00

  • A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA.

    abstract：:We demonstrate that the product of the yeast open reading frame YML005w is required for wybutosine (yW) formation in the phenylalanine-accepting tRNA of the yeast Saccharomyces cerevisiae. tRNA isolated from a deletion mutant of the YML005w gene accumulates 4-demethylwyosine (ImG-14), a precursor lacking three of the ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.06.111

    authors： Kalhor HR,Penjwini M,Clarke S

    更新日期：2005-08-26 00:00:00

  • Cleavage of cottontail rabbit papillomavirus E7 RNA with an anti-E7 ribozyme.

    abstract：:We have designed and constructed a plasmid (pE7RZ-1) that contains a gene for a hammerhead ribozyme that specifically cleaves cottontail rabbit papillomavirus (CRPV) E7 RNA sequences in vitro. The in vitro produced transcripts of pE7RZ-1 cleave CRPV E7 target sequences in trans at 37 degrees C. Pretreatment of pE7RZ-1...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1490

    authors： Wisotzkey JD,Krizenoskas A,DiAngelo S,Kreider JW

    更新日期：1993-04-30 00:00:00

  • N-glycosylation of forms of angiotensin converting enzyme from four mammalian species.

    abstract：:To help clarify bases for the molecular weight and surface charge heterogeneities of forms of somatic angiotensin converting enzyme (ACE), we examined for differences in N-glycosylation. ACE preparations purified from human, guinea pig, rat and rabbit tissues were found to be heterogeneous in terms of numbers of N-gly...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2278

    authors： Ripka JE,Ryan JW,Valido FA,Chung AY,Peterson CM,Urry RL

    更新日期：1993-10-29 00:00:00

  • Isolation of a keto sugar specific agglutinin from rat uterus.

    abstract：:A ketosugar-specific agglutinin has been identified and purified to apparent homogeneity by affinity chromatography from the three days post-coital rat uterus. This protein is not found in other stages of estrous cycle. The agglutinin is glycoprotein, moves as single band with molecular weight 37,000 in polyacrylamide...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90884-3

    authors： Chowdhury M

    更新日期：1986-04-14 00:00:00

  • Induction of adrenomedullin by hypoxia and cobalt chloride in human colorectal carcinoma cells.

    abstract：:Adrenomedullin (ADM) is a vasodilator peptide, first isolated from human pheochromocytoma. To explore the pathophysiological role of ADM in ischemic conditions, we investigated the effects of hypoxia on ADM production and ADM mRNA expression in a cultured human colorectal carcinoma cell line, DLD-1. Northern blot anal...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8131

    authors： Nakayama M,Takahashi K,Murakami O,Shirato K,Shibahara S

    更新日期：1998-02-13 00:00:00

  • Gastrodin inhibits osteoclastogenesis via down-regulating the NFATc1 signaling pathway and stimulates osseointegration in vitro.

    abstract：:Bone is a rigid yet dynamic organ, and this dynamism is mediated by the delicate balance between osteoclastic bone resorption and osteoblastic bone formation. However, excessive activation of osteoclasts is responsible for many bone diseases such as osteoporosis, Paget disease, and tumor bone metastasis. Agents that c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.01.179

    authors： Zhou F,Shen Y,Liu B,Chen X,Wan L,Peng D

    更新日期：2017-03-18 00:00:00

  • Cigarette smoking stimulates lipoxygenase but not cyclooxygenase pathway in platelets.

    abstract：:Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. Arachidonate metabolism through lipoxygenase and cyclooxygenase pathways in platelets was determined. Cigarette smoking increased 12-lipoxygenase activity si...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(83)80172-7

    authors： Chang WC,Fukuda S,Tai HH

    更新日期：1983-09-15 00:00:00